Zobrazeno 1 - 10
of 20
pro vyhledávání: '"John T.-A. Hsu"'
Autor:
Chi-Shuan Fan, Chia-Chi Chen, Li-Li Chen, Kee Voon Chua, Hui-Chen Hung, John T. -A. Hsu, Tze-Sing Huang
Publikováno v:
Cells, Vol 11, Iss 2, p 229 (2022)
M2-polarization and the tumoricidal to tumor-promoting transition are commonly observed with tumor-infiltrating macrophages after interplay with cancer cells or/and other stroma cells. Our previous study indicated that macrophage M2-polarization can
Externí odkaz:
https://doaj.org/article/aef14ebe26b4474881dba999c761fdae
Autor:
An Ning Cheng, Yu-Kang Lo, Yi-Sheng Lin, Tswen-Kei Tang, Chun-Hua Hsu, John T.-A. Hsu, Alan Yueh-Luen Lee
Publikováno v:
EBioMedicine, Vol 36, Iss , Pp 241-251 (2018)
Background: Cdc7-Dbf4 is a conserved serine/threonine kinase that plays an important role in initiation of DNA replication and DNA damage tolerance in eukaryotic cells. Cdc7 has been found overexpressed in human cancer cell lines and tumor tissues, a
Externí odkaz:
https://doaj.org/article/7ad4cb526de04bc380a88d3cff2c32a6
Autor:
Yi-Tai Chou, Fu-Fei Hsu, Dun-Yao Hu, Ying-Chih Chen, Yuan-Hao Hsu, John T.-A. Hsu, Lee-Young Chau
Publikováno v:
Journal of Biomedical Science, Vol 25, Iss 1, Pp 1-9 (2018)
Abstract Background Heme oxygenase (HO) catalyzes NADPH-dependent degradation of heme to liberate iron, carbon monoxide and biliverdin. The interaction between HO and cytochrome P450 reductase (CPR), an electron donor, is essential for HO activity. H
Externí odkaz:
https://doaj.org/article/b3ef167c7dae48139c933af8558647c3
Autor:
Wen-Hsing Lin, Teng-Kuang Yeh, Weir-Torn Jiaang, Kuei-Jung Yen, Chun-Hwa Chen, Chin-Ting Huang, Shih-Chieh Yen, Shu-Yi Hsieh, Ling-Hui Chou, Ching-Ping Chen, Chun-Hsien Chiu, Li-Chun Kao, Yu-Sheng Chao, Chiung-Tong Chen, John T-A Hsu
Publikováno v:
PLoS ONE, Vol 9, Iss 1, p e83160 (2014)
Overexpression or/and activating mutation of FLT3 kinase play a major driving role in the pathogenesis of acute myeloid leukemia (AML). Hence, pharmacologic inhibitors of FLT3 are of therapeutic potential for AML treatment. In this study, BPR1J-340 w
Externí odkaz:
https://doaj.org/article/e5078208d61149adbf9f92f8697b3132
Publikováno v:
PLoS ONE, Vol 9, Iss 11, p e111331 (2014)
Enterovirus 71 (EV-A71) is a neurotropic virus that can cause severe complications involving the central nervous system. No effective antiviral therapeutics are available for treating EV-A71 infection and drug discovery efforts are rarely focused to
Externí odkaz:
https://doaj.org/article/d26b2c67c7094cff9f0b895be2170a24
Autor:
Kai-Cheng Hsu, Hui-Chen Hung, Jim-Tong Horng, Ming-Yu Fang, Chun-Yu Chang, Ling-Ting Li, I-Jung Chen, Yun-Chu Chen, Ding-Li Chou, Chun-Wei Chang, Hsing-Pang Hsieh, Jinn-Moon Yang, John T-A Hsu
Publikováno v:
PLoS ONE, Vol 8, Iss 2, p e56704 (2013)
Infection with influenza virus is a major public health problem, causing serious illness and death each year. Emergence of drug-resistant influenza virus strains limits the effectiveness of drug treatment. Importantly, a dual H275Y/I223R mutation det
Externí odkaz:
https://doaj.org/article/268a59ab9838414a85c0be9a37a85296
Publikováno v:
Cellular microbiology. 16(11)
The non-structural protein 4B (NS4B) of the hepatitis C virus (HCV) is an endoplasmic reticulum (ER) membrane protein comprising two consecutive amphipathic α-helical domains (AH1 and AH2). Its self-oligomerization via the AH2 domain is required for
Autor:
Wen-Hsing, Lin, Jen-Shin, Song, Tzu-Wen, Lien, Chun-Yu, Chang, Szu-Huei, Wu, Yu-Wen, Huang, Teng-Yuan, Chang, Ming-Yu, Fang, Kuei-Jung, Yen, Chun-Hwa, Chen, Chang-Ying, Chu, Hsing-Pang, Hsieh, Yi-Rong, Chen, Yu-Sheng, Chao, John T-A, Hsu
Publikováno v:
Anticancer research. 32(1)
A high-throughput 32D(L858R/T790M) cell-based assay to identify inhibitors of the L858R/T790M mutant epidermal growth factor receptor (EGFR) pathway was established. After screening, ten hits from among 60,000 compounds in our in-house compound libra
Publikováno v:
OncoTargets & Therapy; May2016, Vol. 9, p2961-2973, 13p
Autor:
Hui-Yi, Shiao, Ching-Chuan, Kuo, Jim-Tong, Horng, Shin-Ru, Shih, Sui-Yuan, Chang, Chun-Chen, Liao, John T.-A., Hsu, Prashanth Kumar, Amancha, Yu-Sheng, Chao, Hsing-Pang, Hsieh
Publikováno v:
Journal of the Chinese Chemical Society; Dec2012, Vol. 59 Issue 12, p1548-1554, 7p