Zobrazeno 1 - 10
of 27
pro vyhledávání: '"John T. Tossberg"'
Publikováno v:
Current Research in Immunology, Vol 2, Iss , Pp 52-59 (2021)
Due to potential severity of disease caused by SARS-CoV-2 infection, it is critical to understand both mechanisms of viral pathogenesis as well as diversity of host responses to infection. Reduced A-to-I editing of endogenous double-stranded RNAs (ds
Externí odkaz:
https://doaj.org/article/99bdb7239733469e9ba3ce5531eb37e3
Publikováno v:
Frontiers in Immunology, Vol 13 (2022)
Alu retrotransposons belong to the class of short interspersed nuclear elements (SINEs). Alu RNA is abundant in cells and its repetitive structure forms double-stranded RNAs (dsRNA) that activate dsRNA sensors and trigger innate immune responses with
Externí odkaz:
https://doaj.org/article/cba9c00726d949239c293db01b634cd7
Publikováno v:
Brain Communications. 4
Alzheimer’s disease is the most common form of dementia and recent studies identify a type 1 interferon response in Alzheimer’s disease possibly driving neuro-inflammation and other Alzheimer’s disease pathologies. Loss of adenosine-to-inosine
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ff89f19071a0b3310dd97410da59b5bf
https://doi.org/10.1093/braincomms/fcac238
https://doi.org/10.1093/braincomms/fcac238
Publikováno v:
The Journal of Immunology. 205:2606-2617
Sensors that detect dsRNA stimulate IFN responses as a defense against viral infection. IFN responses are also well documented in a variety of human autoimmune diseases, including relapsing–remitting multiple sclerosis (MS), in which increased IFN
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ba313e62abd995c02bd0337519deb6af
https://doi.org/10.4049/jimmunol.2000384
https://doi.org/10.4049/jimmunol.2000384
Publikováno v:
Biotechniques
We present a method to synthesize mRNAs from synthetic DNA templates that produce biologically active proteins. To illustrate utility, we constructed five unique synthetic DNA templates, produced mRNAs and demonstrated biologic activity of their tran
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::06718a32820649d793bb06245a40b25f
http://europepmc.org/articles/PMC7566775
http://europepmc.org/articles/PMC7566775
Publikováno v:
Current Research in Immunology
Due to potential severity of disease caused by SARS-CoV-2 infection, it is critical to understand both mechanisms of viral pathogenesis as well as diversity of host responses to infection. Reduced A-to-I editing of endogenous double-stranded RNAs (ds
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dd98324ec3c7ed18191a0ff53fab455c
https://pubmed.ncbi.nlm.nih.gov/33969287
https://pubmed.ncbi.nlm.nih.gov/33969287
Cutting Edge: Reduced Adenosine-to-Inosine Editing of Endogenous Alu RNAs in Severe COVID-19 Disease
Publikováno v:
J Immunol
Severe COVID-19 disease is associated with elevated inflammatory responses. One form of Aicardi–Goutières syndrome caused by inactivating mutations in ADAR results in reduced adenosine-to-inosine (A-to-I) editing of endogenous dsRNAs, induction of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9dcc2cd7ad37074b409201f2a68e0ba4
https://pubmed.ncbi.nlm.nih.gov/33782089
https://pubmed.ncbi.nlm.nih.gov/33782089
Autor:
Subramaniam Sriram, Guzel Shaginurova, Charles F. Spurlock, Chandramohan Natarajan, John T. Tossberg, Thomas M. Aune
Publikováno v:
PLoS ONE, Vol 13, Iss 12, p e0208755 (2018)
PLoS ONE
PLoS ONE
Objective We tested the hypothesis that the expression of IL-33 in MS is dynamic and is likely to reflect the clinical and radiological changes during the course of RRMS. Methods MS with either clinical or radiological relapses were recruited for the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a490ddb824cca743dca9385ea8252076
https://doaj.org/article/3a47eaca5fc64df3b9373cd16f25b717
https://doaj.org/article/3a47eaca5fc64df3b9373cd16f25b717
Publikováno v:
The Journal of Immunology. 195:791-795
Of identified genetic variants, HLA polymorphisms confer the greatest risk for developing autoimmune diseases, including rheumatoid arthritis (HLA-DRB1*04). There are strong influences of HLA polymorphisms on cell type–specific gene expression in B
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4b937764110273301d33a5abf92d2620
https://doi.org/10.4049/jimmunol.1500267
https://doi.org/10.4049/jimmunol.1500267
Autor:
Anna E. Patrick, Nancy J. Olsen, Philip S. Crooke, Thomas M. Aune, John T. Tossberg, Charles F. Spurlock
Genome-wide association studies have identified numerous genetic variants conferring autoimmune disease risk. Most of these genetic variants lie outside protein-coding genes hampering mechanistic explorations. Numerous mRNAs are also differentially e
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6a3658e73a6a1f62d717f9403479e3d8
https://europepmc.org/articles/PMC5508524/
https://europepmc.org/articles/PMC5508524/
