Zobrazeno 1 - 10
of 221
pro vyhledávání: '"John T. Povlishock"'
Publikováno v:
Neurobiology of Disease, Vol 171, Iss , Pp 105801- (2022)
Mild traumatic brain injury (mTBI) gives rise to a remarkable breadth of pathobiological consequences, principal among which are traumatic axonal injury and perturbation of the functional integrity of neuronal networks that may arise secondary to the
Externí odkaz:
https://doaj.org/article/d3507715f66345e4bcec81f6d9a9b77c
Autor:
Joshua A. Beitchman, Jonathan Lifshitz, Neil G. Harris, Theresa Currier Thomas, Audrey D. Lafrenaye, Anders H?nell, C. Edward Dixon, John T. Povlishock, Rachel K. Rowe
Publikováno v:
Neurotrauma Reports, Vol 2, Iss 1, Pp 59-75 (2021)
Diffuse brain injury is better described as multi-focal, where pathology can be found adjacent to seemingly uninjured neural tissue. In experimental diffuse brain injury, pathology and pathophysiology have been reported far more lateral than predicte
Externí odkaz:
https://doaj.org/article/b9f9ed6700cf489bbb06c76cf6e5aa6f
Autor:
Patrick M. Kochanek, C. Edward Dixon, Stefania Mondello, Kevin K. K. Wang, Audrey Lafrenaye, Helen M. Bramlett, W. Dalton Dietrich, Ronald L. Hayes, Deborah A. Shear, Janice S. Gilsdorf, Michael Catania, Samuel M. Poloyac, Philip E. Empey, Travis C. Jackson, John T. Povlishock
Publikováno v:
Frontiers in Neurology, Vol 9 (2018)
Current approaches have failed to yield success in the translation of neuroprotective therapies from the pre-clinical to the clinical arena for traumatic brain injury (TBI). Numerous explanations have been put forth in both the pre-clinical and clini
Externí odkaz:
https://doaj.org/article/c981f870a73444de9b3b3084fec2d91d
Publikováno v:
Frontiers in Cellular Neuroscience, Vol 11 (2017)
The axon initial segment (AIS) is the site of action potential (AP) initiation, thus a crucial regulator of neuronal activity. In excitatory pyramidal neurons, the high density of voltage-gated sodium channels (NaV1.6) at the distal AIS regulates AP
Externí odkaz:
https://doaj.org/article/cf94bd78ba644bc799151f3b1d751399
Autor:
Andras Buki, Tamas Doczi, Zalan Szanto, Endre Czeiter, Attila Schwarcz, John T. Povlishock, Jozsef Pal, Erzsebet Kovesdi, Orsolya Farkas, Dora Reglodi, Andrea Tamas, Peter Bukovics
Publikováno v:
International Journal of Molecular Sciences, Vol 13, Iss 7, Pp 8430-8448 (2012)
Pituitary adenylate cyclase activating polypeptide (PACAP) is a bioactive peptide with diverse effects in the nervous system. In addition to its more classic role as a neuromodulator, PACAP functions as a neurotrophic factor. Several neurotrophic fac
Externí odkaz:
https://doaj.org/article/e22f5711a2f3470f9269fa656e5388a4
Autor:
Theresa Currier Thomas, Rachel K. Rowe, Joshua A. Beitchman, John T. Povlishock, Audrey D. Lafrenaye, C. Edward Dixon, Neil G. Harris, Anders Hånell, Jonathan Lifshitz
Publikováno v:
Neurotrauma Reports
Diffuse brain injury is better described as multi-focal, where pathology can be found adjacent to seemingly uninjured neural tissue. In experimental diffuse brain injury, pathology and pathophysiology have been reported far more lateral than predicte
Autor:
Ronald L. Hayes, Stefania Mondello, Karen M. Gorse, Kevin K.W. Wang, Patrick M. Kochanek, Zhihui Yang, John T. Povlishock, Susan A. Walker, Audrey D. Lafrenaye
Publikováno v:
Scientific Reports, Vol 10, Iss 1, Pp 1-17 (2020)
Scientific Reports
Scientific Reports
Serum biomarkers are promising tools for evaluating patients following traumatic brain injury (TBI). However, their relationship with diffuse histopathology remains unclear. Additionally, translatability is a focus of neurotrauma research, however, s
Autor:
John T. Povlishock, Stefania Mondello, Shaun W. Carlson, Janice S. Gilsdorf, Ronald L. Hayes, Ying Deng-Bryant, C. Edward Dixon, Samuel M. Poloyac, Zhihui Yang, Patrick M. Kochanek, Helen M. Bramlett, Philip E. Empey, Kevin K.W. Wang, Deborah A. Shear, W. Dalton Dietrich, Nicole Osier, Audrey D. Lafrenaye
Publikováno v:
Journal of neurotrauma. 38(17)
Loss of plasmalemmal integrity may mediate cell death after traumatic brain injury (TBI). Prior studies in controlled cortical impact (CCI) indicated that the membrane resealing agent Kollidon VA64 improved histopathological and functional outcomes.
Publikováno v:
Ther Hypothermia Temp Manag
We previously demonstrated that rapid posthypothermic rewarming in noninjured animals was capable of damaging cerebral arterioles both at endothelial and smooth muscle levels. Such adverse consequences could be prevented with antioxidants, suggesting
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f9dfba27ff72cfcd84e9e369db6386d0
https://europepmc.org/articles/PMC7757536/
https://europepmc.org/articles/PMC7757536/
Autor:
Ruchira M. Jha, Stefania Mondello, Helen M. Bramlett, C. Edward Dixon, Deborah A. Shear, W. Dalton Dietrich, Kevin K.W. Wang, Zhihui Yang, Ronald L. Hayes, Samuel M. Poloyac, Philip E. Empey, Audrey D. Lafrenaye, Hong Q. Yan, Shaun W. Carlson, John T. Povlishock, Janice S. Gilsdorf, Patrick M. Kochanek
Publikováno v:
J Neurotrauma
Glibenclamide (GLY) is the sixth drug tested by the Operation Brain Trauma Therapy (OBTT) consortium based on substantial pre-clinical evidence of benefit in traumatic brain injury (TBI). Adult Sprague-Dawley rats underwent fluid percussion injury (F
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::774664fbb691a0c860d906bfd3a94e71
http://hdl.handle.net/11570/3190318
http://hdl.handle.net/11570/3190318