Zobrazeno 1 - 10
of 256
pro vyhledávání: '"John T. Patton"'
Publikováno v:
mBio, Vol 14, Iss 6 (2023)
ABSTRACTThe binding of viral RNA to RIG-I-like receptors triggers the formation of mitochondrial antiviral signaling (MAVS) protein aggregates critical for interferon (IFN) expression. Several rotavirus strains have been shown to suppress IFN express
Externí odkaz:
https://doaj.org/article/71836f7d25684a75952ad397298517f7
Publikováno v:
Viruses, Vol 16, Iss 3, p 411 (2024)
Rotaviruses are a significant cause of severe, potentially life-threatening gastroenteritis in infants and the young of many economically important animals. Although vaccines against porcine rotavirus exist, both live oral and inactivated, their effe
Externí odkaz:
https://doaj.org/article/495b76d94ca341e8ad4d905375f6cc31
Autor:
Charlotte Nyblade, Peng Zhou, Maggie Frazier, Annie Frazier, Casey Hensley, Ariana Fantasia-Davis, Shabihah Shahrudin, Miranda Hoffer, Chantal Ama Agbemabiese, Lauren LaRue, Mario Barro, John T. Patton, Viviana Parreño, Lijuan Yuan
Publikováno v:
Viruses, Vol 15, Iss 9, p 1864 (2023)
Human rotavirus (HRV) is a leading cause of viral gastroenteritis in children across the globe. The virus has long been established as a pathogen of the gastrointestinal tract, targeting small intestine epithelial cells and leading to diarrhea, nause
Externí odkaz:
https://doaj.org/article/35075d335df6444e90159d69c84280a7
Publikováno v:
mBio, Vol 13, Iss 6 (2022)
ABSTRACT The interferon (IFN)-inducible 2′,5′-oligoadenylate synthetase (OAS)-RNase L pathway plays a critical role in antiviral immunity. Group A rotaviruses, including the simian SA11 strain, inhibit this pathway through two activities: an E3-l
Externí odkaz:
https://doaj.org/article/4d9dc90e24a146c1948eb37978821ed6
Autor:
Kaitlin A. Davis, John T. Patton
Publikováno v:
Microbial Cell, Vol 4, Iss 11, Pp 387-389 (2017)
Viruses manipulate cellular processes to create an environment favorable to replication. For most viruses, this includes subverting the expression of interferon (IFN), a signaling molecule that can stimulate production of a vast array of antiviral ge
Externí odkaz:
https://doaj.org/article/aba1acf2127f438fbfdcefdb5f250b40
Publikováno v:
Proceedings, Vol 50, Iss 1, p 53 (2020)
Although the incidence of rotavirus diarrheal disease has been reduced by the introduction of neonatal rotavirus vaccines, other enteric viruses—including norovirus, hepatitis E virus (HEV), and astrovirus—remain significant causes of illness. In
Externí odkaz:
https://doaj.org/article/766585112d0e47f68ce1b37c31f2a9de
Publikováno v:
mBio, Vol 8, Iss 4 (2017)
ABSTRACT The rotavirus nonstructural protein NSP1 repurposes cullin-RING E3 ubiquitin ligases (CRLs) to antagonize innate immune responses. By functioning as substrate adaptors of hijacked CRLs, NSP1 causes ubiquitination and proteasomal degradation
Externí odkaz:
https://doaj.org/article/4927981d85ec4c64843ee382e006d0da
Publikováno v:
Viruses, Vol 2, Iss 6, Pp 1340-1346 (2010)
A recently solved structure of the aquareovirus virion (Zhang, X; Jin, L.; Fang, Q; Hui, W.H.; Zhou Z.H. 3.3 Å Cryo-EM Structure of a Nonenveloped Virus Reveals a Priming Mechanism for Cell Entry. Cell 2010, 141, 472-482 [1]) provides new insights i
Externí odkaz:
https://doaj.org/article/3dc32b635bf9430bb97b35b8a4e53e57
Autor:
Michelle M. Arnold, John T. Patton
Publikováno v:
Viruses, Vol 1, Iss 3, Pp 1035-1056 (2009)
Rotavirus is a primary cause of severe dehydrating gastroenteritis in infants and young children. The virus is sensitive to the antiviral effects triggered by the interferon (IFN)-signaling pathway, an important component of the host cell innate immu
Externí odkaz:
https://doaj.org/article/1d4baa56ea9b48dfb054fac304e78c98
Publikováno v:
mBio, Vol 6, Iss 1 (2015)
ABSTRACT NF-κB plays a critical role in the induction and maintenance of innate and adaptive immune transcriptional programs. An associated inhibitor of κB protein (IκB) regulates NF-κB activation and contains a degron motif (DSGΦxS) that underg
Externí odkaz:
https://doaj.org/article/4b88cd1bab5144a2ae6cd96cc7cccc8d