Zobrazeno 1 - 10
of 38
pro vyhledávání: '"John T. Norton"'
Autor:
Yanning Liu, John T. Norton, Mark A. Witschi, Qun Xu, Guohua Lou, Chen Wang, Daniel H. Appella, Zhi Chen, Sui Huang
Publikováno v:
Neoplasia: An International Journal for Oncology Research, Vol 13, Iss 5, Pp 453-460 (2011)
Amonafide is a DNA intercalator in clinical development for the treatment of cancer. The drug has a 5-position amine that is variably acetylated to form a toxic metabolite in humans, increasing adverse effects and complicating the dosing of amonafide
Externí odkaz:
https://doaj.org/article/edefee0d9d424cbbab82f86ad0ab78e0
Autor:
Yongxuan Su, Stephen P. Adams, Eran Zahavy, Sadik C. Esener, Wolf Wrasidlo, John T. Norton, Tomoko Hayashi, Stuart Ibsen
Publikováno v:
Journal of Mass Spectrometry. 48:768-773
The localized conversion of inactive doxorubicin prodrug chemotherapeutics to pharmacalogically active forms is difficult to quantify in mouse tumor models because it occurs only in small regions of tissue. The tumor tissue extraction protocol and LC
Autor:
Maripat Corr, Lloyd S. Miller, John T. Norton, Tomoko Hayashi, John S. Cho, Brian Crain, Dennis A. Carson
Publikováno v:
The Journal of Immunology. 188:2977-2980
Nitrogen-containing bisphosphonates (NBPs) are taken by millions for bone disorders but may cause serious inflammatory reactions. In this study, we used a murine peritonitis model to characterize the inflammatory mechanisms of these agents. At dosage
Autor:
Wolf Wrasidlo, Eran Zahavy, Yongxuan Su, Sadik C. Esener, Tomoko Hayashi, Stuart Ibsen, John T. Norton, Stephen P. Adams
Sparing sensitive healthy tissue from chemotherapy exposure is a critical challenge in the treatment of cancer. The work described here demonstrates the localized in vivo photoactivation of a new chemotherapy prodrug of doxorubicin (DOX). The DOX pro
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bdea7ba946938b7e8ca77028fc14d2a4
https://europepmc.org/articles/PMC4072807/
https://europepmc.org/articles/PMC4072807/
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America. 108(27)
Nitrogen bisphosphonates (NBPs) are commonly prescribed for osteoporosis but have also been found to induce inflammatory reactions and to delay the progression of breast cancer. The inflammatory and anticancer effects of the NBPs might be associated
Autor:
Gregory A. Daniels, Michael Chan, Dennis A. Carson, Christina C.N. Wu, Shiyin Yao, John T. Norton, Rommel I. Tawatao, Tomoko Hayashi, Maripat Corr, Howard B. Cottam
Publikováno v:
Melanoma research. 21(1)
There remains a compelling need for the development of treatments for unresectable melanoma. Agents that stimulate the innate immune response could provide advantages for cell-based therapies. However, there are conflicting reports concerning whether
Autor:
John T. Norton, A. L. Mowry
Publikováno v:
JOM. 1:133-136
Autor:
John T. Norton
Publikováno v:
Advances in X-ray Analysis. 11:401-410
X-ray techniques employing film recording continue to play an important role in the routine determination of residual stresses in metals, particularly where heavy and bulky specimens are involved. The single-exposure technique in which the two diffra
Autor:
John T. Norton
Publikováno v:
Zeitschrift für anorganische Chemie. 28:223-232
Autor:
John T. Norton
Publikováno v:
Journal of the American Ceramic Society. 8:401-406
Mechanical mixtures of alumina and silica in the molecular proportions of 1:1 and 3:2 as well as samples of pure kaolin, have been heated to temperatures above 1500°C and have been examined by the X-ray diffraction method. The diffraction patterns o