Zobrazeno 1 - 10
of 24
pro vyhledávání: '"John T. Minges"'
Autor:
Deborah M. Cholon, Matthew A. Greenwald, Matthew G. Higgs, Nancy L. Quinney, Susan E. Boyles, Suzanne L. Meinig, John T. Minges, Ashlesha Chaubal, Robert Tarran, Carla M. P. Ribeiro, Matthew C. Wolfgang, Martina Gentzsch
Publikováno v:
Cells, Vol 12, Iss 22, p 2618 (2023)
People with cystic fibrosis (pwCF) suffer from chronic and recurring bacterial lung infections that begin very early in life and contribute to progressive lung failure. CF is caused by mutations in the CF transmembrane conductance regulator (CFTR) ge
Externí odkaz:
https://doaj.org/article/ec9881276a44454fb50ae20ca5572f51
Autor:
Rhianna E. Lee, Catherine A. Lewis, Lihua He, Emily C. Bulik-Sullivan, Samuel C. Gallant, Teresa M. Mascenik, Hong Dang, Deborah M. Cholon, Martina Gentzsch, Lisa C. Morton, John T. Minges, Jonathan W. Theile, Neil A. Castle, Michael R. Knowles, Adam J. Kimple, Scott H. Randell
Publikováno v:
The Journal of Clinical Investigation, Vol 132, Iss 18 (2022)
The vast majority of people with cystic fibrosis (CF) are now eligible for CF transmembrane regulator (CFTR) modulator therapy. The remaining individuals with CF harbor premature termination codons (PTCs) or rare CFTR variants with limited treatment
Externí odkaz:
https://doaj.org/article/0342006f024949bb976f55db34ef1e17
Autor:
Martina Gentzsch, Deborah M. Cholon, Nancy L. Quinney, Mary E. B. Martino, John T. Minges, Susan E. Boyles, Tara N. Guhr Lee, Charles R. Esther, Carla M. P. Ribeiro
Publikováno v:
Frontiers in Pharmacology, Vol 12 (2021)
In cystic fibrosis (CF), defective biogenesis and activity of the cystic fibrosis transmembrane conductance regulator (CFTR) leads to airway dehydration and impaired mucociliary clearance, resulting in chronic airway infection and inflammation. The m
Externí odkaz:
https://doaj.org/article/0684a12ec8d9405d9a3000c14aebce39
Autor:
Emily A. Hull-Ryde, John T. Minges, Mary E. B. Martino, Takafumi Kato, Jacqueline L. Norris-Drouin, Carla M. P. Ribeiro
Publikováno v:
International Journal of Molecular Sciences, Vol 22, Iss 6, p 3063 (2021)
New anti-inflammatory treatments are needed for CF airway disease. Studies have implicated the endoplasmic reticulum stress transducer inositol requiring enzyme 1α (IRE1α) in CF airway inflammation. The activation of IRE1α promotes activation of i
Externí odkaz:
https://doaj.org/article/59841918a8584e6e93f5b58c54f752f4
Autor:
Martina, Gentzsch, Deborah M, Cholon, Nancy L, Quinney, Mary E B, Martino, John T, Minges, Susan E, Boyles, Tara N, Guhr Lee, Charles R, Esther, Carla M P, Ribeiro
Publikováno v:
Frontiers in Pharmacology
In cystic fibrosis (CF), defective biogenesis and activity of the cystic fibrosis transmembrane conductance regulator (CFTR) leads to airway dehydration and impaired mucociliary clearance, resulting in chronic airway infection and inflammation. The m
Autor:
Gary L. Glish, Hong Dang, M. Lam, Teresa M. Mascenik, Scott H. Randell, John T. Minges, James E. Keating
Publikováno v:
C58. ACUTE LUNG INJURY: ATYPICAL TRIGGERS.
Publikováno v:
Analytical methods : advancing methods and applications. 10(1)
The rapid release of new tobacco products requires high-throughput quantitative methods to support tobacco research. Sample preparation for LC-MS and GC-MS is time consuming and limits throughput. Paper spray tandem mass spectrometry (PS-MS/MS) is pr
Androgen receptor (AR) transcriptional activity depends on interactions between the AR NH2-terminal region and transcriptional coregulators. A yeast two-hybrid screen of a human testis library using predicted α-helical NH2-terminal fragment AR-(370
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::75c65874507bb9eb91faa72577a13628
Melanoma antigen-A11 (MAGE-A11) is a proto-oncogene involved in androgen receptor signaling and androgen-dependent cell growth. In this report we provide evidence that MAGE-A11 interacts with Skp2 (S phase kinase-associated protein), the substrate re
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5698fdced922ab8f3f832fb0016689bd
Publikováno v:
Molecular and Cellular Endocrinology. 348:403-410
Human androgen receptor (AR) transcriptional activity involves interdomain and coactivator interactions with the agonist-bound AR ligand binding domain (LBD). Structural determinants of the AR NH(2)- and carboxyl-terminal interaction between the AR N