The Insect Peptide CopA3 Increases Colonic Epithelial Cell Proliferation and Mucosal Barrier Function to Prevent Inflammatory Responses in the Gut

Autor: Dae Hong Kim, Peng Zhang, Charalabos Pothoulakis, Ik Hwan Lee, Ho Kim, Li Fang Lu, Junguee Lee, Jae Sam Hwang, Seung Taek Nam, Ji Hong, John T. LaMont, Heon Seok

Publikováno v: Kim, DH; Hwang, JS; Lee, IH; Nam, ST; Hong, J; Zhang, P; et al.(2016). The Insect Peptide CopA3 Increases Colonic Epithelial Cell Proliferation and Mucosal Barrier Function to Prevent Inflammatory Responses in the Gut. JOURNAL OF BIOLOGICAL CHEMISTRY, 291(7), 3209-3223. doi: 10.1074/jbc.M115.682856. UCLA: Retrieved from: http://www.escholarship.org/uc/item/5vq012bb
The Journal of biological chemistry, vol 291, iss 7

The epithelial cells of the gut form a physical barrier against the luminal contents. The collapse of this barrier causes inflammation, and its therapeutic restoration can protect the gut against inflammation. EGF enhances mucosal barrier function an

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2e23cd5be5d38925485d5ab1e348c97d
http://www.escholarship.org/uc/item/5vq012bb

The insect peptide coprisin prevents Clostridium difficile-mediated acute inflammation and mucosal damage through selective antimicrobial activity

Autor: Ho Kim, Hyo Jung Nam, Eun Young Yun, Heon Seok, Jin Ku Kang, Sung-Kuk Kim, Keun Jae Ahn, Charalabos Pothoulakis, John T. LaMont, Jae Sam Hwang

Publikováno v: Antimicrobial agents and chemotherapy. 55(10)

Clostridium difficile -associated diarrhea and pseudomembranous colitis are typically treated with vancomycin or metronidazole, but recent increases in relapse incidence and the emergence of drug-resistant strains of C. difficile indicate the need fo

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9978ad197a6f2058e5b0b59ee8155f5a
https://pubmed.ncbi.nlm.nih.gov/21807975

Mitochondrial generation of reactive oxygen species (ROS) is necessary for IL-8 release from colonocytes exposed to Clostridium difficile toxin A

Autor: John T. LaMont, Charalabos Pothoulakis, Susan J. Hagen, Dan He

Publikováno v: Gastroenterology. 120:A323

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5aaaac469ab7b1ff1c824bd295512fca
https://doi.org/10.1016/s0016-5085(08)81607-1

Immobilized oligosaccharides bind Clostridium difficile toxin B and diminish its effects in human colon

Autor: Ole Hindsgaul, Charalabos Pothoulakis, Etienne Wenzl, Martin Riegler, Ignazio Castagliuolo, Ming L. Chen, Tacettin Sogukoglu, Sabena Kuhnt-Moore, John T. LaMont

Publikováno v: Gastroenterology. 118:A1366

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::6243fb3462fe860b3d8ad701e8e67acb
https://doi.org/10.1016/s0016-5085(00)81335-9

Early mitochondrial damage by Clostridium difficile toxin A (TXA) regulates release of interleukin-8 from human colonocytes

Autor: Charalabos Pothoulakis, Sara Keates, Dan He, John T. LaMont

Publikováno v: Gastroenterology. 118:A323

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::ffbc7b58690462be2cd05fa4c6158605
https://doi.org/10.1016/s0016-5085(00)83386-7