Zobrazeno 1 - 10
of 60
pro vyhledávání: '"John T. Kung"'
Autor:
Chuan-Chuan Huang, Hsiang-Hsuan Sung, Hsiu-Chuan Li, Shi-Chuen Miaw, John T. Kung, Min-Yuan Chou, Betty A. Wu-Hsieh
Publikováno v:
Frontiers in Immunology, Vol 14 (2023)
Specific anti-CD3 treatment is deemed to be a promising therapy for allograft rejection and type 1 diabetes (T1D). Fc receptor (FcR) reduced-binding antibodies, by avoiding adverse effects of Fc and FcR interaction, have good therapeutic potential. W
Externí odkaz:
https://doaj.org/article/e3da1c5589e2465696578dcf32b35bad
Autor:
Yo-Ping Lai, Lu-Cheng Kuo, Been-Ren Lin, Hung-Ju Lin, Chih-Yu Lin, Yi-Ting Chen, Pei-Wen Hsiao, Huan-Tsung Chang, Patrick Chow-In Ko, Hsiao-Chin Chen, Hsiang-Yu Chang, Jean Lu, Hong-Nerng Ho, Betty A. Wu-Hsieh, John T. Kung, Shu-Ching Chen
Publikováno v:
Communications Biology, Vol 4, Iss 1, Pp 1-12 (2021)
Lai et al. report that the immunosuppressive molecule CD73 is negatively regulated by CD28 costimulation during CD8+ T cell activation. Their study implicates a lack of CD28 costimulation renders CD8+ T cells immunosuppressive and less able to elimin
Externí odkaz:
https://doaj.org/article/5b062bd4e6884a5f96c38bd03af38f9e
Publikováno v:
Biology, Vol 1, Iss 1, Pp 18-42 (2012)
Due to a mutation in the Foxp3 transcription factor, Scurfy mice lack regulatory T-cells that maintain self-tolerance of the immune system. They develop multi-organ inflammation (MOI) and die around four weeks old. The affected organs are skin, tail,
Externí odkaz:
https://doaj.org/article/ca555e2f6af24e7baebe08b715303d0f
Publikováno v:
Hepatology. 77:1486-1498
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::434e85a878c504788b137df50c2e83bc
https://doi.org/10.1002/hep.32788
https://doi.org/10.1002/hep.32788
Publikováno v:
Hepatology (Baltimore, Md.)REFERENCES.
Long-lasting immunological memory is the ultimate goal of vaccination. Homeostatic maintenance of memory CD8We engineered a genetically engineered mouse in which IL-15R complementary DNA (cDNA) had been inserted in-frame with lecithin-retinol acyltra
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::951a4c5a4949edf9c26d1a8ecec5dc2a
https://pubmed.ncbi.nlm.nih.gov/36106384
https://pubmed.ncbi.nlm.nih.gov/36106384
Autor:
Pei Wen Hsiao, Lu Cheng Kuo, Hong Nerng Ho, Betty A. Wu-Hsieh, Hung-Ju Lin, Chih Yu Lin, Huan Tsung Chang, Yi-Ting Chen, Jean Lu, Been Ren Lin, Hsiang Yu Chang, Yo-Ping Lai, Hsiao Chin Chen, Patrick Chow-In Ko, John T. Kung, Shu-Ching Chen
Publikováno v:
Communications Biology, Vol 4, Iss 1, Pp 1-12 (2021)
CD28 is required for T cell activation as well as the generation of CD4+Foxp3+ Treg. It is unclear, however, how CD28 costimulation affects the development of CD8+ T cell suppressive function. Here, by use of Hepa1.6.gp33 in vitro killing assay and B
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cd36e66cab53447bd95ebb9c4035121d
https://doaj.org/article/5b062bd4e6884a5f96c38bd03af38f9e
https://doaj.org/article/5b062bd4e6884a5f96c38bd03af38f9e
Autor:
Yo-Ping, Lai, Lu-Cheng, Kuo, Been-Ren, Lin, Hung-Ju, Lin, Chih-Yu, Lin, Yi-Ting, Chen, Pei-Wen, Hsiao, Huan-Tsung, Chang, Patrick Chow-In, Ko, Hsiao-Chin, Chen, Hsiang-Yu, Chang, Jean, Lu, Hong-Nerng, Ho, Betty A, Wu-Hsieh, John T, Kung, Shu-Ching, Chen
Publikováno v:
Communications Biology
CD28 is required for T cell activation as well as the generation of CD4+Foxp3+ Treg. It is unclear, however, how CD28 costimulation affects the development of CD8+ T cell suppressive function. Here, by use of Hepa1.6.gp33 in vitro killing assay and B
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::5d05e70808a054362da1acb2e3c21631
https://pubmed.ncbi.nlm.nih.gov/34011962
https://pubmed.ncbi.nlm.nih.gov/34011962
Autor:
Yi-Ting Chen, John T. Kung
Publikováno v:
Journal of immunology (Baltimore, Md. : 1950). 204(12)
BCR-mediated tonic signaling is an indispensable requirement for the survival of follicular B (FOB) cells and Burkitt lymphoma (BL) cells. FOB cells of the I-A12% mutant mouse express unfolded protein response and are extremely short lived. Among the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8ab8b22becfcd40cf1713433e718754f
https://pubmed.ncbi.nlm.nih.gov/32376649
https://pubmed.ncbi.nlm.nih.gov/32376649
Publikováno v:
The Journal of Immunology. 198:1928-1943
The development and activation of MHC class II (MHC-II)–restricted CD4+ T cells are distinct immunological processes that are strictly MHC-II–dependent. To address their relative dependence on MHC-II, we established a novel ENU-induced mutant mou
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0f1dd6f2e7a67fea841a071ca9efc0c7
https://doi.org/10.4049/jimmunol.1600967
https://doi.org/10.4049/jimmunol.1600967
Publikováno v:
Journal of immunology (Baltimore, Md. : 1950). 201(10)
BCR engagement leads to activation and clonal expansion of B cells. The I-A12% mutant mouse possesses a branch site point mutation in the H2-Aa gene that causes highly reduced I-Aa protein expression. As I-A is a heterodimer made up of I-Aa and I-Ab,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0b3c6ccc7525cb031b8811f061622ce3
https://pubmed.ncbi.nlm.nih.gov/30305329
https://pubmed.ncbi.nlm.nih.gov/30305329