Zobrazeno 1 - 8
of 8
pro vyhledávání: '"John T. Henri"'
Autor:
Jeffrey N. Hemenway, Sajiv K. Nair, Pekka Jarho, Gunda I. Georg, Valentino J. Stella, David VanderVelde, John T. Henri
Publikováno v:
Journal of Pharmaceutical Sciences. 99:1810-1825
N-acyl-urea derivatives of carbamazepine (CBZ) were synthesized through the reactions of iminostilbene with acyl-isocyanates to form N-glycyl-carbamazepine (N-Gly-CBZ, after a deprotection step) or N-acetyl-carbamazepine (N-acetyl-CBZ). N-Gly-CBZ was
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3bcab9f869d918ad46d8065c6f42658e
https://doi.org/10.1002/jps.21952
https://doi.org/10.1002/jps.21952
Autor:
Sunil A. David, Gunda I. Georg, David Vander Velde, John T. Henri, Richard H. Himes, Sajiv K. Nair, Ting Lan Chiu, Bollu S. Reddy, Ramappa Chakrasali, Elizabeth A. Amin, Emily A. Reiff, Jack F. Greiner
Publikováno v:
The Journal of Organic Chemistry. 75:86-94
Three photoaffinity labeled derivatives of epothilone D were prepared by total synthesis, using efficient novel asymmetric synthesis methods for the preparation of two important synthetic building blocks. The key step for the asymmetric synthesis of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fb6fba875342da743f14b5984997024e
https://doi.org/10.1021/jo901752v
https://doi.org/10.1021/jo901752v
Autor:
David VanderVelde, Sajiv K. Nair, Gunda I. Georg, Richard H. Himes, Emily A. Reiff, Oliver E. Hutt, Jack F. Greiner, Bollu S. Reddy, Jun Inagaki, Elizabeth A. Amin, Ting Lan Chiu, John T. Henri
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 19:3293-3296
The total synthesis of 22-(3-azidobenzoyloxy)methyl epothilone C is described as a potential photoaffinity probe to elucidate the beta-tubulin binding site. A sequential Suzuki-aldol-Yamaguchi macrolactonization strategy was utilized employing a nove
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::674c6652d0607744da6be034a4c91fc2
https://doi.org/10.1016/j.bmcl.2009.04.077
https://doi.org/10.1016/j.bmcl.2009.04.077
Publikováno v:
Tetrahedron Letters. 37:6615-6618
Total synthesis of PA-48153C Pironetin — a potent immunosuppressant is described.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1e85bf25cc23005c73fe7d61560d2886
https://doi.org/10.1016/0040-4039(96)01413-x
https://doi.org/10.1016/0040-4039(96)01413-x
Autor:
Sajiv K. Nair, Jun Inagaki, B.S Narayan Reddy, John T. Henri, Gunda I. Georg, Jack F. Greiner, Emily A. Reiff
Publikováno v:
Tetrahedron Letters. 45:5845-5847
Two practical catalytic asymmetric reductions to introduce the epothilone C15 stereocenter are described (Itsuno–Corey reduction and Noyori hydrogenation).
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3c67293d7a6765eca18a5376ed298762
https://doi.org/10.1016/j.tetlet.2004.06.009
https://doi.org/10.1016/j.tetlet.2004.06.009
Publikováno v:
ChemInform. 31
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ef84b141346661a0c09efa2c6fbc3876
https://doi.org/10.1002/chin.200036287
https://doi.org/10.1002/chin.200036287
Autor:
Sajiv K. Nair, John T. Henri, Gunda I. Georg, Jack F. Greiner, David VanderVelde, Ting Lan Chiu, Bollu S. Reddy, Oliver E. Hutt, Emily A. Reiff, Elizabeth A. Amin, Richard H. Himes
Publikováno v:
Bioorganicmedicinal chemistry letters. 18(17)
The total synthesis of C25-benzyloxy epothilone C is described. A sequential Suzuki–Aldol–Yamaguchi macrolactonization strategy was utilized employing a novel derivatized C8–C12 fragment. The C25-benzyloxy analog exhibited significantly reduced
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cae63626c486d6470f1fbd7a643350d5
https://pubmed.ncbi.nlm.nih.gov/18684624
https://pubmed.ncbi.nlm.nih.gov/18684624
Publikováno v:
Phytochemistry. 68(14)
Natural product substances have historically served as the most significant source of new leads for pharmaceutical development. However, with the advent of robotics, bioinformatics, high throughput screening (HTS), molecular biology-biotechnology, co
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5ab9326d8a7d081754df668e8f89e383
https://pubmed.ncbi.nlm.nih.gov/17574638
https://pubmed.ncbi.nlm.nih.gov/17574638