Zobrazeno 1 - 10
of 30
pro vyhledávání: '"John T. Durkin"'
Autor:
Donna Bozyczko-Coyne, Steven C. Almo, Jean Husten, Michael S. Saporito, Richard W. Scott, Alexander A. Fedorov, Mark A. Ator, Chung Ho Park, Diebold James L, Ming Tao, Thelma S. Angeles, Sheryl L. Meyer, John P. Mallamo, Lisa D. Aimone, Elena V. Fedorov, Kurt A. Josef, Beverly P. Holskin, Robert L. Hudkins, Joanne R. Mathiasen, John T. Durkin
Publikováno v:
Journal of Medicinal Chemistry. 51:5680-5689
The optimization of the dihydronaphthyl[3,4-a]pyrrolo[3,4-c]carbazole-5-one R(2) and R(12) positions led to the identification of the first MLK1 and MLK3 subtype-selective inhibitors within the MLK family. Compounds 14 (CEP-5104) and 16 (CEP-6331) di
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5006c141cc94502df1d9156dde918c8a
https://doi.org/10.1021/jm8005838
https://doi.org/10.1021/jm8005838
Autor:
George Gessner, Beverly P. Holskin, Matthew S. Reed, Jan Pohl, John T. Durkin, Karla K. Kopec, Brian M. Steffy, Chrysanthe M. Spais, Sheryl L. Meyer, Thelma S. Angeles, Mark A. Ator
Publikováno v:
Biochemistry. 43:16348-16355
Mixed-lineage kinase 1 (MLK1) is a mitogen-activated protein kinase kinase kinase capableof activating the c-Jun NH 2 -terminal kinase (JNK) pathway. Full-length MLK1 has 1104 amino acids anda domain structure identical to MLK2 and MLK3. Immunoblot a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9f011ed0eed524358f0425cdfc746aa6
https://doi.org/10.1021/bi049866y
https://doi.org/10.1021/bi049866y
Autor:
Maroney Anna, George W. Gessner, James P. Finn, John T. Durkin, Zhiheng Xu, Richard W. Scott, Thomas J. Connors, Thelma S. Angeles, Lloyd A. Greene, Mary J. Savage, Jeffry L. Vaught, Sheryl L. Meyer
Publikováno v:
Journal of Biological Chemistry. 276:25302-25308
CEP-1347 (KT7515) promotes neuronal survival at dosages that inhibit activation of the c-Jun amino-terminal kinases (JNKs) in primary embryonic cultures and differentiated PC12 cells after trophic withdrawal and in mice treated with 1-methyl-4-phenyl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5e5abd23051d6c3b524b9b0a8f5b9002
https://doi.org/10.1074/jbc.m011601200
https://doi.org/10.1074/jbc.m011601200
Autor:
John T. Durkin, Markus Krygier
Publikováno v:
Review of International Economics. 8:760-774
This paper examines the relationship between per capita GDP differences and bilateral intraindustry trade shares. The relationship is negative in OLS regressions but positive in fixed-effect regressions, and evidence is presented suggesting this is d
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::da315fa5f5d1bdafe71e19db3ba7e2f9
https://doi.org/10.1111/1467-9396.00255
https://doi.org/10.1111/1467-9396.00255
Autor:
John T. Durkin
Publikováno v:
Review of International Economics. 5:401-411
This paper analyzes a dynamic Ricardian model of international trade in which relative differences in technology are endogenously determined by investments in innovation by competitive firms. It considers the impact of these investments on trade patt
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4b2bca2961a929e5430b236850f74861
https://doi.org/10.1111/1467-9396.00065
https://doi.org/10.1111/1467-9396.00065
Autor:
John T. Durkin
Publikováno v:
Review of International Economics. 4:218-233
This paper analyzes a formal, dynamic model of the center-periphery problem. The model features falling relative demand for agricultural goods, a higher rate of technical change in manufacturing, and a quality-differentiated manufactured good. Income
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::60998ef26443a77fce7e5b64b333e582
https://doi.org/10.1111/j.1467-9396.1996.tb00098.x
https://doi.org/10.1111/j.1467-9396.1996.tb00098.x
Autor:
Suzanne Mistretta, Mary J. Savage, Robert Siman, Richard W. Scott, T. Loh, John T. Durkin, Stephen P. Trusko
Publikováno v:
Journal of Biological Chemistry. 268:16602-16609
Proteolytic processing of the beta-amyloid precursor proteins (APP) is required for release of the beta/A4 protein and its deposition into the amyloid plaques characteristic of aging and Alzheimer's disease. We have examined the involvement of acidic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8e70e335cfd52cd0b5d3a6660fc28abf
https://doi.org/10.1016/s0021-9258(19)85462-5
https://doi.org/10.1016/s0021-9258(19)85462-5
Publikováno v:
Journal of Molecular Biology. 231:1102-1121
We examined the properties of membrane-spanning channels formed by gramicidin analogues that differ from [Val 1 ]gramicidin A by having a single residue deletion or insertion at the formyl-NH terminus and of hybrid channels formed between such 14-, 1
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::cd6582723457389be593c80f73a2059b
https://doi.org/10.1006/jmbi.1993.1355
https://doi.org/10.1006/jmbi.1993.1355
Publikováno v:
Brain research. 1374
Alternative promoter usage and mRNA precursor splicing produce three amino-terminal isoforms of the human glycine transporter type 1 (GlyT1). To enable discovery of pharmacological tools that might distinguish them, each of these isoforms was stably
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::53b3cf2cab0a4900bfc6fa57d4fe2e00
https://pubmed.ncbi.nlm.nih.gov/21138739
https://pubmed.ncbi.nlm.nih.gov/21138739
Autor:
Joseph M. Salvino, Karla Kopec, Eva Zuvich, Dorothy G. Flood, Beth Ann McKenna, Michael J. Marino, Mark A. Ator, Justin Schreiber, Maciej Gasior, John T. Durkin
Publikováno v:
Biochemical pharmacology. 80(9)
Inhibition of the glycine transporter type 1 (GlyT1) leading to potentiation of the glycine site (GlyB) on the N-methyl-d-aspartate (NMDA) receptor has been proposed as a novel therapeutic approach for schizophrenia. However, sarcosine-based GlyT1 in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::23032cd44fc5d4bdbbbc1d7639a6f2a5
https://pubmed.ncbi.nlm.nih.gov/20637735
https://pubmed.ncbi.nlm.nih.gov/20637735