Zobrazeno 1 - 10
of 32
pro vyhledávání: '"John T. Catlow"'
Autor:
Bridget L. Morse, Lisa Hong Chen, John T. Catlow, John K. Fallon, Philip C. Smith, Kathleen M. Hillgren
Publikováno v:
Frontiers in Pharmacology, Vol 12 (2021)
The role of organic cation transporter 1 (OCT1) in humans is gaining attention as data emerges regarding its role in physiology, drug exposure, and drug response. OCT1 variants with decreased in vitro function correlate well with altered exposure of
Externí odkaz:
https://doaj.org/article/0052c40fa9564f39aeb93353b20d9483
Autor:
Paul L. Ornstein, David S. Bredt, Vanessa N. Barth, Eric S. Nisenbaum, Kar-Chan Choong, Wenhong Guo, Warren J. Porter, Kevin Matthew Gardinier, Emanuele Sher, Yue-Wei Qian, Jon K. Reel, Christian C. Felder, John T. Catlow, Rosa Maria A. Simmons, Kevin D. Burris, Kelly L. Knopp, Douglas Linn Gernert, Chunjin Ding, Steven Swanson, Anne B. Need, Theron M. Wall, He Wang, Akihiko Kato, Douglas A. Schober, Ruud Zwart, Benjamin L. Adams, Jeffrey M. Witkin
Publikováno v:
Journal of Pharmacology and Experimental Therapeutics. 369:345-363
Nonselective glutamate α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptor antagonists are efficacious in chronic pain but have significant tolerability issues, likely arising from the ubiquitous expression of AMPA receptors in the
Autor:
Lisa Hong Chen, John K. Fallon, Philip C. Smith, John T. Catlow, Kathleen M. Hillgren, Bridget L. Morse
Publikováno v:
Frontiers in Pharmacology
Frontiers in Pharmacology, Vol 12 (2021)
Frontiers in Pharmacology, Vol 12 (2021)
The role of organic cation transporter 1 (OCT1) in humans is gaining attention as data emerges regarding its role in physiology, drug exposure, and drug response. OCT1 variants with decreased in vitro function correlate well with altered exposure of
Autor:
Akihiko Kato, Scott D. Gleason, Warren J. Porter, Xingjie Ping, Jonathan Hobbs, Donald R. Gehlert, Douglas Linn Gernert, Kevin Matthew Gardinier, Jon K. Reel, Jeffrey M. Witkin, Douglas A. Schober, Xiaoming Jin, Jodi L. Smith, John T. Catlow
Publikováno v:
CNS & Neurological Disorders - Drug Targets. 16:1099-1110
Background & objective 6-[(1S)-1-[1-[5-(2-hydroxyethoxy)-2-pyridyl]pyrazol-3-yl]ethyl]- 3H-1,3-benzothiazol-2-one (LY3130481 or CERC-611) is a selective antagonist of AMPA receptors containing transmembrane AMPA receptor regulatory protein (TARP) γ-
Autor:
Frances Lu, Bryan G. Johnson, Daniel Ursu, Joan H. Carter, Lisa M. Broad, Kofi Adragni, Shane Atwell, Jing Wang, David K. Clawson, Beverly A. Heinz, Steven P. Swanson, James A. Monn, Qi Chen, Helene E. Sanger, David B. Shaw, Steven Marc Massey, Xushan Wang, Marijane Russell, Steven S. Henry, Junliang Hao, Rajni M. Bhardwaj, Diseroad Benjamin Alan, David L. McKinzie, Brian G. Getman, John T. Catlow
Publikováno v:
Journal of Medicinal Chemistry. 61:2303-2328
Multiple therapeutic opportunities have been suggested for compounds capable of selective activation of metabotropic glutamate 3 (mGlu3) receptors, but small molecule tools are lacking. As part of our ongoing efforts to identify potent, selective, an
Autor:
Chuanxi Xiang, Steven Swanson, Joan H. Carter, Paul L. Ornstein, Lisa M. Broad, Charles H. Mitch, Xu Shan Wang, Wesley H. Anderson, Helen E. Sanger, Renhua Li, Jeffrey M. Witkin, Stephon C. Smith, Stephen M. Fitzjohn, Francesca Pasqui, Xia Li, Jodi L. Smith, James A. Monn, Beverly A. Heinz, John T. Catlow
Publikováno v:
Neuropharmacology. 115:100-114
Metabotropic glutamate 2/3 (mGlu2/3) receptors are of considerable interest owing to their role in modulating glutamate transmission via presynaptic, postsynaptic and glial mechanisms. As part of our ongoing efforts to identify novel ligands for thes
Autor:
Wesley H. Anderson, Paul L. Ornstein, Vladamir Tolstikov, Guy Carter, Renhua Li, Brian J. Eastwood, Carl D Overshiner, Alexander Nikolayev, Kurt Rasmussen, Stephen Smith, Gary Gilmour, Stephen Swanson, Linda M. Rorick-Kehn, Xia Li, Keith A. Wafford, John T. Catlow, Jeffrey M. Witkin, Stephen N. Mitchell, Charles H. Mitch, Ming-Shang Kuo, Jennifer Li, James A. Monn
Publikováno v:
Journal of Pharmacology and Experimental Therapeutics. 361:68-86
The ability of the N-methyl-d-aspartate receptor antagonist ketamine to alleviate symptoms in patients suffering from treatment-resistant depression (TRD) is well documented. In this paper, we directly compare in vivo biologic responses in rodents el
Autor:
Charles H. Mitch, Aiping Zhang, Mercedes Carpintero, Bradley Condon, C. Groshong, Shane Atwell, John W. Koss, Carl D Overshiner, Jeffrey M. Schkeryantz, Stephon C. Smith, Mark G. Bures, James E. Matt, S.R. Wasserman, Adam M. Fivush, Wesley Seidel, Carlos Jaramillo, K. Conners, David W. Bedwell, Jeffrey M. Witkin, Maria-Jesus Blanco, Daniel Ray Mayhugh, Steven James Quimby, Bruce A. Dressman, Keith A. Wafford, John T. Catlow, Allie Edward Tripp, Paul L. Ornstein, Mario Barberis, José Francisco Soriano, Steven Swanson, Beverly A. Heinz, Jon A. Erickson, Xia Li, Iain MacEwan, Thomas C. Britton, James A. Monn, Susana García-Cerrada, Jing Wang, Mark Donald Chappell, Eric George Tromiczak, Renhua Li, José Eugenio de Diego, Christine Sougias, Tatiana Natali Vetman, Xushan Wang, Stephen Antonysamy
Publikováno v:
Journal of Medicinal Chemistry. 59:10974-10993
As part of our ongoing efforts to identify novel ligands for the metabotropic glutamate 2 and 3 (mGlu2/3) receptors, we have incorporated substitution at the C3 and C4 positions of the (1S,2R,5R,6R)-2-amino-bicyclo[3.1.0]hexane-2,6-dicarboxylic acid
Autor:
Bruce A. Dressman, Charles H. Mitch, Mercedes Carpintero, Susana García-Cerrada, John T. Catlow, Tatiana Natali Vetman, Wesley Seidel, Mark Donald Chappell, Jeffrey M. Schkeryantz, Albert Khilevich, Xushan Wang, Allie Edward Tripp, Jeffrey M. Witkin, Maria-Jesus Blanco, Renhua Li, Stephon C. Smith, José Francisco Soriano, Mario Barberis, Steven Swanson, Xia Li, Carlos Jaramillo, Beverly A. Heinz, Thomas C. Britton, Carl D Overshiner, Keith A. Wafford, Eric George Tromiczak, José Eugenio de Diego, James E. Matt, David W. Bedwell, Steven James Quimby, Adam M. Fivush, Paul L. Ornstein
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 26:5663-5668
Negative modulators of metabotropic glutamate 2 & 3 receptors demonstrate antidepressant-like activity in animal models and hold promise as novel therapeutic agents for the treatment of major depressive disorder. Herein we describe our efforts to pre
Autor:
Akihiko Kato, Hong Yu, Stephen M. Fitzjohn, Francesca Pasqui, Thomas E. Fitch, Yue-Wei Qian, Jon K. Reel, Chunjin Ding, Ruud Zwart, He Wang, Keith A. Wafford, Paul L. Ornstein, Kurt Rasmussen, Matthew Lee, John T.R. Isaac, Kevin D. Burris, Scott D. Gleason, Warren J. Porter, David S. Bredt, Douglas A. Schober, John T. Catlow, Jeffrey M. Witkin, Beverly A. Heinz, Kevin Matthew Gardinier, Emanuele Sher, Douglas Linn Gernert, Yuan Tu, Eric S. Nisenbaum
Publikováno v:
Nature Medicine. 22:1496-1501
Pharmacological manipulation of specific neural circuits to optimize therapeutic index is an unrealized goal in neurology and psychiatry. AMPA receptors are important for excitatory synaptic transmission, and their antagonists are antiepileptic. Alth