Zobrazeno 1 - 8
of 8
pro vyhledávání: '"John T. Canty"'
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-15 (2023)
The mechanisms of microtubule-based mitochondrial transport remain poorly understood. Here, the authors show that the mitochondrial TRAK adaptors activate the dynein-dynactin complex, enhance the motility of kinesin, and can scaffold both motors to c
Externí odkaz:
https://doaj.org/article/7e3e19ed48734ff3bc953c96b71cc8c6
Autor:
John T. Canty, Ahmet Yildiz
Publikováno v:
Trends Biochem Sci
Trends in biochemical sciences, vol 45, iss 5
Trends in biochemical sciences, vol 45, iss 5
Cytoplasmic dynein is an AAA+ motor that drives the transport of many intracellular cargoes towards the minus-end of microtubules. Previous in vitro studies characterized isolated dynein as an exceptionally weak motor that moves slowly and diffuses o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e79b0f8437e91255315ef8140fc21de7
https://doi.org/10.1016/j.tibs.2020.02.002
https://doi.org/10.1016/j.tibs.2020.02.002
In neurons, mitochondria are transported to distal regions for supplying energy and buffer Ca2+. Mitochondrial transport is mediated by Miro and TRAK adaptors that recruit kinesin and dynein-dynactin. To understand how mitochondria are transported by
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::53a8e30fb34cf3058399525c124fd9c1
https://doi.org/10.1101/2021.07.30.454553
https://doi.org/10.1101/2021.07.30.454553
Autor:
Mohamed M. Elshenawy, Liya Oster, John T. Canty, Zhou Zhou, Scott C. Blanchard, Ahmet Yildiz, Luke S. Ferro
Publikováno v:
Nature chemical biology
Cytoplasmic dynein is an ATP-driven motor that transports intracellular cargos along microtubules. Dynein adopts an inactive conformation when not attached to a cargo, and motility is activated when dynein assembles with dynactin and a cargo adaptor.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6f44e4ce26235d1db067e9d49fc9e068
https://doi.org/10.1038/s41589-019-0352-0
https://doi.org/10.1038/s41589-019-0352-0
Publikováno v:
Annu Rev Biophys
Annual review of biophysics, vol 50, iss 1
Annual review of biophysics, vol 50, iss 1
Dyneins make up a family of AAA+ motors that move toward the minus end of microtubules. Cytoplasmic dynein is responsible for transporting intracellular cargos in interphase cells and mediating spindle assembly and chromosome positioning during cell
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e766297cb9b724982a7c206d799b5cd9
https://pubmed.ncbi.nlm.nih.gov/33957056
https://pubmed.ncbi.nlm.nih.gov/33957056
Autor:
John T. Canty, Ahmet Yildiz, Sophie Dumont, Ronja Houtekamer, Dorine Hintzen, Andrea Serra-Marques
Publikováno v:
The Journal of cell biology, vol 219, iss 12
The Journal of Cell Biology
The Journal of Cell Biology
NuMA disruption causes nuclear defects, and it was unclear if this is due to NuMA's essential spindle function. Serra-Marques et al. show that NuMA keeps chromosomes together at nuclear formation and promotes a mechanically robust nucleus independent
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::23304be9a8a3a642b3f8d8481644a5b0
Publikováno v:
Experimental Eye Research. 113:32-40
Aquaporin-0 (AQP0), the primary water channel in lens fiber cells, is critical to lens development, organization, and function. In the avascular lens there is thought to be an internal microcirculation associated with fluid movement. Although AQP0 is
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3fb114840939612ae2fdcebe8c3eac49
https://doi.org/10.1016/j.exer.2013.04.022
https://doi.org/10.1016/j.exer.2013.04.022
Publikováno v:
Nature Communications
Potassium channels selectively conduct K+, primarily to the exclusion of Na+, despite the fact that both ions can bind within the selectivity filter. Here we perform crystallographic titration and single-channel electrophysiology to examine the compe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b55524b1ff93e541ac14b1b5884202d2
http://europepmc.org/articles/PMC3831281
http://europepmc.org/articles/PMC3831281