Zobrazeno 1 - 10
of 26
pro vyhledávání: '"John T. Callaghan"'
Autor:
Todd C. Skaar, Rachel A. Myers, Roger B. Fillingim, John T. Callaghan, Emily Cicali, Michael T. Eadon, Erica N. Elwood, Geoffrey S. Ginsburg, Sheryl Lynch, Khoa A. Nguyen, Aniwaa Owusu Obeng, Haesuk Park, Victoria M. Pratt, Marc Rosenman, Azita Sadeghpour, Saskia Shuman, Rajbir Singh, Emma M. Tillman, Simona Volpi, Kristin Wiisanen, Almut G. Winterstein, Carol R. Horowitz, Deepak Voora, Lori Orlando, Hrishikesh Chakraborty, Sara Van Driest, Josh F. Peterson, Larisa A. Cavallari, Julie A. Johnson, Paul R. Dexter, the IGNITE Pragmatic Trials Network
Publikováno v:
Clinical and Translational Science, Vol 17, Iss 8, Pp n/a-n/a (2024)
Abstract Chronic pain is a prevalent condition with enormous economic burden. Opioids such as tramadol, codeine, and hydrocodone are commonly used to treat chronic pain; these drugs are activated to more potent opioid receptor agonists by the hepatic
Externí odkaz:
https://doaj.org/article/56442bcb216e492ab0211fa40c8e5b76
Autor:
Elizabeth J. Rowe, Tyler Shugg, Reynold C. Ly, Santosh Philips, Marc B. Rosenman, John T. Callaghan, Milan Radovich, Brian R. Overholser, Bryan P. Schneider, James E. Tisdale, Todd C. Skaar
Publikováno v:
Frontiers in Cardiovascular Medicine, Vol 9 (2022)
IntroductionDrug-induced prolongation of the heart rate-corrected QT interval (QTc) is associated with increased risk for the potentially fatal arrhythmia torsades de pointes. Due to arrhythmia risk, clinical trials with cancer therapeutics often exc
Externí odkaz:
https://doaj.org/article/3d9cbe7fcc884cde80a448883983fe03
Autor:
Ingrid F. Metzger, PhD, Troy C. Quigg, MD, Noam Epstein, Abdulateef O. Aregbe, MD, Nancy Thong, John T. Callaghan, MD, PhD, David A. Flockhart, MD, PhD, Anne T. Nguyen, Colleen K. Stevens, Samir K. Gupta, Zeruesenay Desta, PhD
Publikováno v:
Current Therapeutic Research, Vol 76, Iss C, Pp 64-69 (2014)
Background: Efavirenz exhibits multiple interactions with drug-metabolizing enzymes and transporters, and for this reason efavirenz-based HIV therapy is associated with altered pharmacokinetics of coadministered drugs. Probably by the same mechanism,
Externí odkaz:
https://doaj.org/article/5952c64f1d9647cc8c4e8f9919cc8ce8
Autor:
Caroline Flora Samer, Larisa H. Cavallari, Andrew A. Monte, Andrew A. Somogyi, Rachel Huddart, Evan D. Kharasch, Kelly E. Caudle, Gualberto Ruaño, J. Steven Leeder, Andrea Gaedigk, Sara L. Van Driest, Cynthia A. Prows, Kristine R. Crews, Teri E. Klein, Todd C. Skaar, Henry M. Dunnenberger, Cyrine E. Haidar, Daniel J. Müller, John T. Callaghan, Mohamed Nagy, Katrin Sangkuhl
Publikováno v:
Clin Pharmacol Ther
Clinical Pharmacology and Therapeutics (2021)
Clinical Pharmacology and Therapeutics (2021)
Opioids are mainly used to treat both acute and chronic pain. Several opioids are metabolized to some extent by CYP2D6 (codeine, tramadol, hydrocodone, oxycodone, and methadone). Polymorphisms in CYP2D6 have been studied for an association with the c
Autor:
Marc B. Rosenman, John T. Callaghan, Mustafa A. Hyder, Milan Radovich, Elizabeth J Rowe, Bryan P. Schneider, Tyler Shugg, Reynold C. Ly, Zeruesenay Desta, Todd C. Skaar, Victoria M. Pratt, Santosh Philips
Publikováno v:
JCO Precis Oncol
PURPOSE Precision medicine approaches, including germline pharmacogenetics (PGx) and management of drug-drug interactions (DDIs), are likely to benefit patients with advanced cancer who are frequently prescribed multiple concomitant medications to tr
Autor:
Rebecca J. Song, Xuan-Mai T. Nguyen, Rachel Quaden, Yuk-Lam Ho, Amy C. Justice, David R. Gagnon, Kelly Cho, Christopher J. O'Donnell, John Concato, J. Michael Gaziano, Luc Djoussé, Ildiko Halasz, Daniel Federman, Jean Beckham, Scott E. Sherman, Peruvemba Sriram, Philip S. Tsao, Edward J. Boyko, Junzhe Xu, Frank Lederle, Louis J. Dellitalia, Rachel McArdle, Laurence Kaminsky, Alan C. Swann, Mark B. Hamner, Hermes J. Florez, Prashant Pandya, Gerardo Villarreal, Peter Wilson, Timothy R. Morgan, Lori Davis, Robin A. Hurley, Laurence Meyer, Sunil K. Ahuja, Eric P. Konicki, David Cohen, Jack Lichy, Jeffrey Whittle, Kathlyn Sue Haddock, Karl D. Straub, John T. Callaghan, Samuel M. Aguayo, Samir Gupta, Ronald G. Washburn, Mary E. Oehlert, Adriana M. Hung, Agnes Wallbom, Robert Keith, Elif Sonel, Ronald B. Schifman, Richard D. Childress, Michael F. Godschalk, Alan R. Shuldiner, Padmashri Rastogi, Salvador Gutierrez, Ronald Fernando, Pran R. Iruvanti, Darshana Jhala, Carlos Rosado-Rodriguez, Stephen M. Mastorides, John B. Harley, Kristin Mattocks, Brooks Robey, Robert T. Striker, Michael Rauchman, John Wells, Zuhair K. Ballas, Susan S. Woods, Shing Shing Yeh, Nora R. Ratcliffe, Jon B. Klein, Adam G. Golden, Harold M. Ginzburg, Satish Sharma, Kris Ann K. Oursler, Mary A. Whooley, Gretchen Gibson, null Heinz
Publikováno v:
The American Journal of Cardiology. 121:1162-1168
Moderate alcohol consumption has been associated with a lower risk of coronary artery disease (CAD) in the general population but has not been well studied in US veterans. We obtained self-reported alcohol consumption from Million Veteran Program par
Autor:
Brandon T. Gufford, Zeruesenay Desta, Todd C. Skaar, Michael T. Eadon, Paul R. Dexter, Brian S. Decker, Kenneth D. Levy, Victoria M. Pratt, John T. Callaghan, Yifei Zhang, Yong Zang, Ann M. Holmes, Cathy R. Fulton, Marc B. Rosenman
Background: Tramadol and codeine are metabolized by CYP2D6 and are subject to drug–gene and drug–drug interactions. Methods: This interim analysis examined prescribing behavior and efficacy in 102 individuals prescribed tramadol or codeine while
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::689a4798b81da35ead329387dcd0e7ad
https://europepmc.org/articles/PMC6562829/
https://europepmc.org/articles/PMC6562829/
Autor:
Jason L, Vassy, Annjanette, Stone, John T, Callaghan, Margaret, Mendes, Laurence J, Meyer, Victoria M, Pratt, Ronald M, Przygodzki, Maren T, Scheuner, Jessica, Wang-Rodriguez, Steven A, Schichman
Publikováno v:
Genetics in medicine : official journal of the American College of Medical Genetics. 21(8)
Autor:
Michael T. Eadon, David A. Flockhart, Brian S. Decker, Rebecca C. Pierson, Brandon T. Gufford, Janet S. Carpenter, N Dave, John T. Callaghan, J. D. Robarge, Mustafa Hyder, Rolf P. Kreutz, Victoria M. Pratt, Marc B. Rosenman, Raj Vuppalanchi, Paul R. Dexter, C.A. McDonald, Ann M. Holmes, Kenneth D. Levy, David M. Haas, Avinash S. Patil, Eric A. Benson, Zeruesenay Desta, Todd C. Skaar
Publikováno v:
Clinical Pharmacology & Therapeutics. 100:63-66
Hospital systems increasingly utilize pharmacogenomic testing to inform clinical prescribing. Successful implementation efforts have been modeled at many academic centers. In contrast, this report provides insights into the formation of a pharmacogen
DASH Score and Subsequent Risk of Coronary Artery Disease: The Findings From Million Veteran Program
Autor:
Luc Djoussé, Yuk‐Lam Ho, Xuan‐Mai T. Nguyen, David R. Gagnon, Peter W.F. Wilson, Kelly Cho, J. Michael Gaziano, Ildiko Halasz, Daniel Federman, Jean Beckham, Scott E. Sherman, Peruvemba Sriram, Philip S. Tsao, Edward J. Boyko, Junzhe Xu, Frank Lederle, Louis J. Dellitalia, Rachel McArdle, Laurence Kaminsky, Alan C. Swann, Mark B. Hamner, Hermes J. Florez, Prashant Pandya, Gerardo Villarreal, Peter Wilson, Timothy R. Morgan, Lori Davis, Robin A. Hurley, Laurence Meyer, Sunil K. Ahuja, Eric P. Konicki, David Cohen, Jack Lichy, Jeffrey Whittle, Kathlyn Sue Haddock, Karl D. Straub, John T. Callaghan, Samuel M. Aguayo, Samir Gupta, Ronald G. Washburn, Mary E. Oehlert, Adriana M. Hung, Agnes Wallbom, Robert Keith, Elif Sonel, Ronald B. Schifman, Richard D. Childress, Michael F. Godschalk, Alan R. Shuldiner, Padmashri Rastogi, Salvador Gutierrez, Ronald Fernando, Pran R. Iruvanti, Darshana Jhala, Carlos Rosado‐Rodriguez, Stephen M. Mastorides, John B. Harley, Kristin Mattocks, Robert T. Striker, Michael Rauchman, John Wells, Zuhair K. Ballas, Susan S. Woods, Shing Yeh, Nora R. Ratcliffe, Jon B. Klein, Adam G. Golden, Harold M. Ginzburg, Satish Sharma, Kris Ann K. Oursler, Mary A. Whooley, Gretchen Gibson
Publikováno v:
Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease
Background While adherence to healthful dietary patterns has been associated with a lower risk of coronary artery disease (CAD) in the general population, limited data are available among US veterans. We tested the hypothesis that adherence to Dietar