Zobrazeno 1 - 10
of 180
pro vyhledávání: '"John T. Brosnan"'
Autor:
Jessica O'Reilly, Faith Pangilinan, Karsten Hokamp, Per M. Ueland, John T. Brosnan, Margaret E. Brosnan, Lawrence C. Brody, Anne M. Molloy
Publikováno v:
Molecular Genetics and Metabolism Reports, Vol 16, Iss , Pp 20-22 (2018)
The glycine cleavage system (GCS) is a complex of four enzymes enabling glycine to serve as a source of one-carbon units to the cell. We asked whether concentrations of glycine, dimethylglycine, formate, and serine in blood are influenced by variatio
Externí odkaz:
https://doaj.org/article/d52bdc74bb394762af21ac43bb90cace
Autor:
S. L. Christian, John T. Brosnan, Margaret E. Brosnan, Garrett Tingley, Y. Gao, Theerawat Pongnopparat
Publikováno v:
Amino Acids. 53:1589-1595
One-carbon units, critical intermediates for cell growth, may be produced by a variety of means, one of which is via the production of formate. Excessive formate accumulation, known as formate overflow and a characteristic of oxidative cancer, has be
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7f72e6cb7668ff1fa639f5c48c8c5e37
https://doi.org/10.1007/s00726-021-03078-5
https://doi.org/10.1007/s00726-021-03078-5
Autor:
Margaret E. Brosnan, John T. Brosnan
Publikováno v:
J Nutr
Histidine is a dietary essential amino acid because it cannot be synthesized in humans. The WHO/FAO requirement for adults for histidine is 10 mg · kg body weight(−1) · d(−1). Histidine is required for synthesis of proteins. It plays particular
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3f8f4214d8bc5792dfedd0e8611e3b05
https://doi.org/10.1093/jn/nxaa079
https://doi.org/10.1093/jn/nxaa079
Autor:
Anna E. Thalacker-Mercer, Joanna Fiddler, John T. Brosnan, Jamie E. Blum, Margaret E. Brosnan, Simon G. Lamarre, Sally P. Stabler, Whitney N Phinney, Yuwen Xiu, Martha S. Field
BackgroundAdequate cellular thymidylate (dTMP) pools are essential for preservation of nuclear and mitochondrial genome stability. Previous studies have indicated that disruption in dTMP synthesis in the nucleus leads to increased uracil misincorpora
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::90da88fa5a8d7b4cf374ad33800ca920
https://doi.org/10.1101/2021.04.12.439270
https://doi.org/10.1101/2021.04.12.439270
Autor:
Sara K. Young, Kathy A. Clow, John T. Brosnan, Luke MacMillan, Garrett Tingley, Margaret E. Brosnan, Edward Randell
Publikováno v:
The Journal of Nutrition. 148:358-363
Background Formate is produced in mitochondria via the catabolism of serine, glycine, dimethylglycine, and sarcosine. Formate produced by mitochondria may be incorporated into the cytosolic folate pool where it can be used for important biosynthetic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::411dbee21b4b57846c8ecf6d7401599e
https://doi.org/10.1093/jn/nxx057
https://doi.org/10.1093/jn/nxx057
Publikováno v:
FEBS Letters. 591:2426-2438
Here, we found that formate, an essential one-carbon metabolite, activates superoxide (O2·-)/hydrogen peroxide (H2 O2 ) release from mitochondria. Sodium formate (30 μm) induces a significant increase in O2·-/H2 O2 production in liver mitochondria
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d8aa921e5ca8f4e1fefb1ac5ab08a462
https://doi.org/10.1002/1873-3468.12777
https://doi.org/10.1002/1873-3468.12777
Autor:
Brian Harnett, Margaret E. Brosnan, Jenika D. Marshall, Theerawat Pongnopparat, Garrett Tingley, Luke MacMillan, John T. Brosnan
Publikováno v:
J Nutr
Background Formate can be incorporated into 10-formyl-tetrahydrofolate (10-formyl-THF), which is a substrate for purine synthesis, and after further reduction of the one-carbon group, may be used as a substrate for thymidylate synthesis and for homoc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::09ae05d92b1b6489745d20d41e071ccd
https://pubmed.ncbi.nlm.nih.gov/31912134
https://pubmed.ncbi.nlm.nih.gov/31912134
Autor:
John T. Brosnan, Margaret E. Brosnan
Publikováno v:
Annual Review of Nutrition. 36:369-388
Formate, the only non-tetrahydrofolate (THF)-linked intermediate in one-carbon metabolism, is produced in mammals from a variety of metabolic sources. It occurs in serum of adults at a concentration of approximately 30 μM. Its principal function lie
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::67c64f0d8a6a16428ce25d0698c7c66e
https://doi.org/10.1146/annurev-nutr-071715-050738
https://doi.org/10.1146/annurev-nutr-071715-050738
Autor:
John T. Brosnan, Margaret E. Brosnan
Publikováno v:
Amino Acids. 48:1785-1791
The daily requirement of a 70-kg male for creatine is about 2 g; up to half of this may be obtained from a typical omnivorous diet, with the remainder being synthesized in the body Creatine is a carninutrient, which means that it is only available to
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::51200bab49d05902c0fd5e77b2b440de
https://doi.org/10.1007/s00726-016-2188-1
https://doi.org/10.1007/s00726-016-2188-1
Autor:
Young-In Kim, Carly E Visentin, Margaret E. Brosnan, Yvonne Lamers, John T. Brosnan, Theerawat Pongnopparat, Shannon Masih, Marie A. Caudill, Lesley Plumptre, Olga V. Malysheva, Deborah L O'Connor, Howard Berger
Publikováno v:
The American journal of clinical nutrition. 110(5)
Background One-carbon metabolism, responsible for purine and thymidylate synthesis and transmethylation reactions, plays a critical role in embryonic and fetal development. Formate is a key player in one-carbon metabolism. In contrast to other one-ca
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::88791bf0f52fdba4bd364a58e40fdcd3
https://pubmed.ncbi.nlm.nih.gov/31504120
https://pubmed.ncbi.nlm.nih.gov/31504120