Zobrazeno 1 - 10
of 36
pro vyhledávání: '"John T. Barr"'
Publikováno v:
Risk analysis : an official publication of the Society for Risk Analysis. 42(2)
This work investigates aspects of the global sensitivity analysis of computer codes when alternative plausible distributions for the model inputs are available to the analyst. Analysts may decide to explore results under each distribution or to aggre
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4e12d03f43126f67f35072ac2e7b36ad
https://pubmed.ncbi.nlm.nih.gov/35274350
https://pubmed.ncbi.nlm.nih.gov/35274350
Autor:
John T Barr, Henry J Wienkers, Brooke M. Rock, Zhican Wang, Dan A. Rock, Larry C. Wienkers, Xiaoshan Min
Publikováno v:
Drug Metabolism and Disposition. 48:508-514
Experiments designed to identify the mechanism of cytochrome P450 inactivation are critical to drug discovery. Small molecules irreversibly inhibit P450 enzymatic activity via two primary mechanisms: apoprotein adduct formation or heme modification.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ee45a877b4b2b24541954c1b9c51f60b
https://doi.org/10.1124/dmd.119.089813
https://doi.org/10.1124/dmd.119.089813
Publikováno v:
Methods in molecular biology (Clifton, N.J.). 2342
Aldehyde oxidase (AO) has emerged as an important drug metabolizing enzyme over the last decade. Several compounds have failed in the clinic because the clearance or toxicity was underestimated by preclinical species. Human AO is much more active tha
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::d5549db4ba2bb60c0cf40883ff3af8e2
https://pubmed.ncbi.nlm.nih.gov/34272698
https://pubmed.ncbi.nlm.nih.gov/34272698
Autor:
John T, Barr, Otito F, Iwuchukwu
Publikováno v:
Methods in molecular biology (Clifton, N.J.). 2342
This chapter deals with practical considerations on key issues such as choosing an enzyme source, determining linear conditions, and choosing appropriate substrate and organic solvent concentrations. Practical solutions for working with limited resou
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::8a5ec08b5c15713d4157dac642996d49
https://pubmed.ncbi.nlm.nih.gov/34272708
https://pubmed.ncbi.nlm.nih.gov/34272708
Publikováno v:
Drug Metabolism and Disposition. 47:419-423
It is well recognized that nonspecific binding of a drug within an in vitro assay (fu) can have a large impact on in vitro to in vivo correlations of intrinsic clearance. Typically, this value is determined experimentally across multiple species in t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ee94fdb03246d7c18521dc9a64276c4c
https://doi.org/10.1124/dmd.118.085936
https://doi.org/10.1124/dmd.118.085936
Publikováno v:
Methods in Molecular Biology ISBN: 9781071615539
Aldehyde oxidase (AO) has emerged as an important drug metabolizing enzyme over the last decade. Several compounds have failed in the clinic because the clearance or toxicity was underestimated by preclinical species. Human AO is much more active tha
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2653fe6a9725118edc7954461e7f33e1
https://doi.org/10.1007/978-1-0716-1554-6_10
https://doi.org/10.1007/978-1-0716-1554-6_10
Autor:
John T. Barr, Otito F. Iwuchukwu
Publikováno v:
Methods in Molecular Biology ISBN: 9781071615539
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::32eac573de905729572c3ff1a93500e5
https://doi.org/10.1007/978-1-0716-1554-6_20
https://doi.org/10.1007/978-1-0716-1554-6_20
Autor:
Michael K. McGrath, Ali Abolhassani, Luke Guy, Ahmed M. Elshazly, John T. Barrett, Nahid F. Mivechi, David A. Gewirtz, Patricia V. Schoenlein
Publikováno v:
Frontiers in Endocrinology, Vol 15 (2024)
Estrogen receptor positive (ER+) breast cancer is the most common breast cancer diagnosed annually in the US with endocrine-based therapy as standard-of-care for this breast cancer subtype. Endocrine therapy includes treatment with antiestrogens, suc
Externí odkaz:
https://doaj.org/article/3cca55924e8440b18214f9cbedfcc9fd
Autor:
Matthew E. Layton, Jr Jr White, Mary F. Paine, John T. Barr, Nicholas H. Oberlies, Vanessa González-Pérez, Brandon T. Gufford
Publikováno v:
CPT: Pharmacometrics & Systems Pharmacology
Quantitative prediction of herb-drug interaction risk remains challenging. A quantitative framework to assess a potential interaction was used to evaluate a mechanism not previously tested in humans. The semipurified milk thistle product, silibinin,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bda960c2a285fd32e6d3f36306d803cb
http://europepmc.org/articles/PMC4759704
http://europepmc.org/articles/PMC4759704
Publikováno v:
Drug Metabolism and Disposition. 43:34-41
The mechanistic understanding of interactions between diet-derived substances and conventional medications in humans is nascent. Most investigations have examined cytochrome P450-mediated interactions. Interactions mediated by other phase I enzymes a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f30518d195cf77514afd3fa415bd93d4
https://doi.org/10.1124/dmd.114.061192
https://doi.org/10.1124/dmd.114.061192