Výsledky vyhledávání - "John T-A Hsu"

Akademický článek

Evaluation of the antitumor effects of BPR1J-340, a potent and selective FLT3 inhibitor, alone or in combination with an HDAC inhibitor, vorinostat, in AML cancer.

Autor: Wen-Hsing Lin, Teng-Kuang Yeh, Weir-Torn Jiaang, Kuei-Jung Yen, Chun-Hwa Chen, Chin-Ting Huang, Shih-Chieh Yen, Shu-Yi Hsieh, Ling-Hui Chou, Ching-Ping Chen, Chun-Hsien Chiu, Li-Chun Kao, Yu-Sheng Chao, Chiung-Tong Chen, John T-A Hsu

Publikováno v: PLoS ONE, Vol 9, Iss 1, p e83160 (2014)

Overexpression or/and activating mutation of FLT3 kinase play a major driving role in the pathogenesis of acute myeloid leukemia (AML). Hence, pharmacologic inhibitors of FLT3 are of therapeutic potential for AML treatment. In this study, BPR1J-340 w

Externí odkaz: https://doaj.org/article/e5078208d61149adbf9f92f8697b3132

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Akademický článek

The combination effects of licl and the active leflunomide metabolite, A771726, on viral-induced interleukin 6 production and EV-A71 replication.

Autor: Hui-Chen Hung, Shin-Ru Shih, Teng-Yuan Chang, Ming-Yu Fang, John T-A Hsu

Publikováno v: PLoS ONE, Vol 9, Iss 11, p e111331 (2014)

Enterovirus 71 (EV-A71) is a neurotropic virus that can cause severe complications involving the central nervous system. No effective antiviral therapeutics are available for treating EV-A71 infection and drug discovery efforts are rarely focused to

Externí odkaz: https://doaj.org/article/d26b2c67c7094cff9f0b895be2170a24

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Akademický článek

Parallel screening of wild-type and drug-resistant targets for anti-resistance neuraminidase inhibitors.

Autor: Kai-Cheng Hsu, Hui-Chen Hung, Jim-Tong Horng, Ming-Yu Fang, Chun-Yu Chang, Ling-Ting Li, I-Jung Chen, Yun-Chu Chen, Ding-Li Chou, Chun-Wei Chang, Hsing-Pang Hsieh, Jinn-Moon Yang, John T-A Hsu

Publikováno v: PLoS ONE, Vol 8, Iss 2, p e56704 (2013)

Infection with influenza virus is a major public health problem, causing serious illness and death each year. Emergence of drug-resistant influenza virus strains limits the effectiveness of drug treatment. Importantly, a dual H275Y/I223R mutation det

Externí odkaz: https://doaj.org/article/268a59ab9838414a85c0be9a37a85296

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Akademický článek

Extracellular HSP90α Induces MyD88-IRAK Complex-Associated IKKα/β−NF-κB/IRF3 and JAK2/TYK2−STAT-3 Signaling in Macrophages for Tumor-Promoting M2-Polarization

Autor: Chi-Shuan Fan, Chia-Chi Chen, Li-Li Chen, Kee Voon Chua, Hui-Chen Hung, John T. -A. Hsu, Tze-Sing Huang

Publikováno v: Cells, Vol 11, Iss 2, p 229 (2022)

M2-polarization and the tumoricidal to tumor-promoting transition are commonly observed with tumor-infiltrating macrophages after interplay with cancer cells or/and other stroma cells. Our previous study indicated that macrophage M2-polarization can

Externí odkaz: https://doaj.org/article/aef14ebe26b4474881dba999c761fdae

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Reticulon 3 interacts with NS4B of the hepatitis C virus and negatively regulates viral replication by disrupting NS4B self-interaction

Autor: Ming-Jhan, Wu, Po-Yuan, Ke, John T-A, Hsu, Chau-Ting, Yeh, Jim-Tong, Horng

Publikováno v: Cellular microbiology. 16(11)

The non-structural protein 4B (NS4B) of the hepatitis C virus (HCV) is an endoplasmic reticulum (ER) membrane protein comprising two consecutive amphipathic α-helical domains (AH1 and AH2). Its self-oligomerization via the AH2 domain is required for

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::5f1f10b1e5eca44c46c5c87fc54bf6a4
https://pubmed.ncbi.nlm.nih.gov/24898729

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A high-throughput cell-based screening for L858R/T790M mutant epidermal growth factor receptor inhibitors

Autor: Wen-Hsing, Lin, Jen-Shin, Song, Tzu-Wen, Lien, Chun-Yu, Chang, Szu-Huei, Wu, Yu-Wen, Huang, Teng-Yuan, Chang, Ming-Yu, Fang, Kuei-Jung, Yen, Chun-Hwa, Chen, Chang-Ying, Chu, Hsing-Pang, Hsieh, Yi-Rong, Chen, Yu-Sheng, Chao, John T-A, Hsu

Publikováno v: Anticancer research. 32(1)

A high-throughput 32D(L858R/T790M) cell-based assay to identify inhibitors of the L858R/T790M mutant epidermal growth factor receptor (EGFR) pathway was established. After screening, ten hits from among 60,000 compounds in our in-house compound libra

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::5ec6a1906bfbcd8cae17b0c31e0abdaf
https://pubmed.ncbi.nlm.nih.gov/22213300

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