Zobrazeno 1 - 10
of 318
pro vyhledávání: '"John T Williams"'
Autor:
Seksiri Arttamangkul, Andrew Plazek, Emily J Platt, Haihong Jin, Thomas F Murray, William T Birdsong, Kenner C Rice, David L Farrens, John T Williams
Publikováno v:
eLife, Vol 8 (2019)
Identifying neurons that have functional opioid receptors is fundamental for the understanding of the cellular, synaptic and systems actions of opioids. Current techniques are limited to post hoc analyses of fixed tissues. Here we developed a fluores
Externí odkaz:
https://doaj.org/article/afd221fdbb4c475bbda925ce0c8607b0
RIM is essential for stimulated but not spontaneous somatodendritic dopamine release in the midbrain
Autor:
Brooks G Robinson, Xintong Cai, Jiexin Wang, James R Bunzow, John T Williams, Pascal S Kaeser
Publikováno v:
eLife, Vol 8 (2019)
Action potentials trigger neurotransmitter release at active zones, specialized release sites in axons. Many neurons also secrete neurotransmitters or neuromodulators from their somata and dendrites. However, it is unclear whether somatodendritic rel
Externí odkaz:
https://doaj.org/article/d43753a1786341ae86e468de7555a641
Publikováno v:
eLife, Vol 7 (2018)
Phosphorylation of the μ-opioid receptor (MOR) is known as a key step in desensitization and internalization but the role in the development of long-term tolerance at the cellular level is not known. Viral expression of wild type (exWT) and mutant M
Externí odkaz:
https://doaj.org/article/f6d691f4144f42ce8c816130d6510b70
Autor:
Brooks G Robinson, Alec F Condon, Daniela Radl, Emiliana Borrelli, John T Williams, Kim A Neve
Publikováno v:
eLife, Vol 6 (2017)
The dopamine D2 receptor has two splice variants, D2S (Short) and D2L (Long). In dopamine neurons, both variants can act as autoreceptors to regulate neuronal excitability and dopamine release, but the roles of each variant are incompletely character
Externí odkaz:
https://doaj.org/article/6247159021874db79607b5d47e0e255b
Publikováno v:
PLoS ONE, Vol 12, Iss 11, p e0187732 (2017)
Neuronal cells receive a variety of excitatory and inhibitory signals which they process to generate an output signal. In order to study the interaction between excitatory and inhibitory receptors with exogenously applied transmitters in the same pre
Externí odkaz:
https://doaj.org/article/53909d172a064b8490229574dd48f919
Autor:
Stephanie C Gantz, Brooks G Robinson, David C Buck, James R Bunzow, Rachael L Neve, John T Williams, Kim A Neve
Publikováno v:
eLife, Vol 4 (2015)
D2 autoreceptors regulate dopamine release throughout the brain. Two isoforms of the D2 receptor, D2S and D2L, are expressed in midbrain dopamine neurons. Differential roles of these isoforms as autoreceptors are poorly understood. By virally express
Externí odkaz:
https://doaj.org/article/8ad20fd828744c2a90d9e5d99be6908d
Autor:
John T. Williams, Matthew Giletto, Elizabeth R. Haiderer, Bilal Aleiwi, Teresa Krieger-Burke, Edmund Ellsworth, Robert B. Abramovitch
Publikováno v:
Microbiology Spectrum, Vol 12, Iss 1 (2024)
ABSTRACT Addressing drug resistance in Mycobacterium tuberculosis (Mtb) requires the development of new drugs with new targets. We previously identified 13 MmpL3 inhibitors from a screen of a small library of Mtb growth inhibitors. In this report, we
Externí odkaz:
https://doaj.org/article/acd6a828201141989036fd29913f9168
Autor:
John T. Williams, Jacob J. Baker, Huiqing Zheng, Shelby J. Dechow, Jared Fallon, Megan Murto, Veronica J. Albrecht, Haleigh N. Gilliland, Andrew J. Olive, Robert B. Abramovitch
Publikováno v:
mSphere, Vol 8, Iss 5 (2023)
ABSTRACT Mycobacteria can colonize environments where the availability of metal ions is limited. Biological or inorganic chelators play an important role in limiting metal availability, and we developed a model to examine Mycobacterium smegmatis surv
Externí odkaz:
https://doaj.org/article/de6e211fa6394e21a1a6d66507766a86
Autor:
Samantha J. Nelson, John T. Williams, John A. Buglino, Subhalaxmi Nambi, Lisa J. Lojek, Michael S. Glickman, Thomas R. Ioerger, Christopher M. Sassetti
Publikováno v:
mSphere, Vol 8, Iss 4 (2023)
ABSTRACT Mycobacterium tuberculosis is exposed to a variety of stresses during a chronic infection, as the immune system simultaneously produces bactericidal compounds and starves the pathogen of essential nutrients. The intramembrane protease, Rip1,
Externí odkaz:
https://doaj.org/article/3ff0ef3e4c504a0da4ca3f3ee42264fd
Autor:
Joseph J. Lebowitz, Aditi Banerjee, Claire Qiao, James R. Bunzow, John T. Williams, Pascal S. Kaeser
Publikováno v:
Cell Reports, Vol 42, Iss 1, Pp 111915- (2023)
Summary: Modes of somatodendritic transmission range from rapid synaptic signaling to protracted regulation over distance. Somatodendritic dopamine secretion in the midbrain leads to D2 receptor-induced modulation of dopamine neurons on the timescale
Externí odkaz:
https://doaj.org/article/ebc7818d6b3c4ade8c5d72abb0722ab2