Zobrazeno 1 - 10
of 10
pro vyhledávání: '"John T Piazza"'
Autor:
Richard L Cullum, Lauren M Lucas, Jared I Senfeld, John T Piazza, Logan T Neel, Kanupriya Whig, Ling Zhai, Mackenzie H Harris, Cristina C Rael, Darby C Taylor, Laura J Cook, David P Kaufmann, Christopher P Mill, Megan A Jacobi, Forrest T Smith, Mark Suto, Robert Bostwick, Ram B Gupta, Allan E David, David J Riese Ii
Publikováno v:
PLoS ONE, Vol 15, Iss 12, p e0243901 (2020)
Whereas recent clinical studies report metastatic melanoma survival rates high as 30-50%, many tumors remain nonresponsive or become resistant to current therapeutic strategies. Analyses of The Cancer Genome Atlas (TCGA) skin cutaneous melanoma (SKCM
Externí odkaz:
https://doaj.org/article/b577cffb2bf84042b2d2698e0a334423
Autor:
Laura J. Cook, Ram B. Gupta, Christopher P. Mill, Richard L. Cullum, Cristina C. Rael, Megan A. Jacobi, Logan Neel, Ling Zhai, Mark J. Suto, Allan E. David, Robert Bostwick, Jared I. Senfeld, Lauren M. Lucas, Forrest Smith, Kanupriya Whig, David J. Riese, Darby C. Taylor, Mackenzie H. Harris, John T. Piazza, David P. Kaufmann
Publikováno v:
PLoS ONE, Vol 15, Iss 12, p e0243901 (2020)
PLoS ONE
PLoS ONE
Whereas recent clinical studies report metastatic melanoma survival rates high as 30–50%, many tumors remain nonresponsive or become resistant to current therapeutic strategies. Analyses of The Cancer Genome Atlas (TCGA) skin cutaneous melanoma (SK
Autor:
Jacob Valiyaveettil, Meagan Thomas, Xi Chen, Brian T. Eberhardt, Ashley S. Lindsey, Larry Yet, Luciana Madeira da Silva, John T. Piazza, Joshua C. Canzoneri, Dennis Otali, Kevin Lee, Gary A. Piazza, Alexandra M. Fajardo, Adam B. Keeton, Nan Li, Veronica Ramirez-Alcantara, Bing Zhu, William E. Grizzle, Evrim Gurpinar
Publikováno v:
Oncotarget
// Bing Zhu 1 , Ashley Lindsey 1 , Nan Li 2 , Kevin Lee 1 , Veronica Ramirez-Alcantara 1 , Joshua C. Canzoneri 1 , Alexandra Fajardo 1 , Luciana Madeira da Silva 1 , Meagan Thomas 1 , John T. Piazza 1 , Larry Yet 3 , Brian T. Eberhardt 3 , Evrim Gurp
Autor:
Mackenzie H. Harris, Laura J. Cook, Ram B. Gupta, David J. Riese, Allan E. David, John T. Piazza, Darby C. Taylor, Richard L. Cullum, David Z. Kaufmann, Cristina C. Rael, Logan Neel, Lauren M. Lucas, Jared I. Senfeld
Publikováno v:
Cancer Research. 80:A19-A19
Introduction: Gain-of-function mutations in the gene that encodes the ErbB4 receptor tyrosine kinase have been found in a significant fraction of melanoma samples. Melanoma cell lines that harbor some of these mutations are dependent on ErbB4 for pro
Autor:
Kevin Lee, Alexandra M. Fajardo, Bernard D. Gary, Suzanne Russo, Evrim Gurpinar, Mary Pat Moyer, Veronica Ramirez-Alcantara, John T. Piazza, Xi Chen, Sara Sigler, Adam B. Keeton, Danuel J. Laan, Wenyan Lu, Meagan Thomas, Yonghe Li, Yaguang Xi, Joshua C. Canzoneri, Joel Andrews, Larry Yet, Gary A. Piazza, Nan Li, William E. Grizzle, Brian T. Eberhardt, Bing Zhu
Publikováno v:
Oncogene
The cyclic nucleotide phosphodiesterase 10A (PDE10) has been mostly studied as a therapeutic target for certain psychiatric and neurological conditions, although a potential role in tumorigenesis has not been reported. Here we show that PDE10 is elev
Autor:
Ram B. Gupta, Richard L. Cullum, Allan E. David, John T. Piazza, David J. Riese, Logan Neel, Lauren M. Lucas, Jared I. Senfeld
Publikováno v:
Molecular Cancer Therapeutics. 17:A159-A159
Introduction: Gain-of-function mutations in the ErbB4 receptor tyrosine kinase have been found in a significant fraction of melanoma cell lines that are dependent on ErbB4 for proliferation. However, there is a scarcity of therapeutics for treating t
Autor:
David J. Riese, Logan Neel, Richard L. Cullum, John T. Piazza, Allan E. David, Ram B. Gupta, Jared I. Senfeld
Publikováno v:
Cancer Research. 77:1245-1245
Introduction: Gain-of-function mutations in the ErbB4 receptor tyrosine kinase have been found in a significant fraction of melanoma cell lines that are dependent on ErbB4 for proliferation. However, there is a scarcity of therapeutics for treating t
Autor:
William E. Grizzle, Yaguang Xi, Veronica Ramirez-Alcantara, Kevin Lee, Alexandra M. Fajardo, Suzanne Russo, Evrim Gurpinar, Gary A. Piazza, Bernary D. Gary, John T. Piazza, Bing Zhu, Joel Andrews, Nan Li, Wenyan Lu, Joshua C. Canzoneri, Adam B. Keeton, Yonghe Li, Sara Sigler, Larry Yet, Xi Chen
Publikováno v:
Cancer Research. 74:1773-1773
The cyclic nucleotide phosphodiesterase10A (PDE10) has been studied as a therapeutic target for certain psychiatric and neurological conditions, although a potential role in tumorigenesis has not been reported. Here we report that PDE10 is elevated i
Autor:
Brian T. Eberhardt, Evrim Gurpinar, Yaguang Xi, Adam B. Keeton, Bernard D. Gary, Joel Andrews, Bing Zhu, Yonghe Li, Nan Li, William E. Grizzle, John T. Piazza, Alexandra M. Fajardo, Veronica Ramirez, Suzanne Russo, Joshua Canzeroni, Larry Yet, Sara Sigler, Xi Chen, Gary A. Piazza, Kevin Lee
Publikováno v:
Journal of Clinical Oncology. 32:503-503
503 Background: Elevation of intracellular cGMP is known to inhibit tumor proliferation and induce apoptosis, although the phosphodiesterase (PDE) isozymes that regulate cGMP levels in tumor cells have not been well studied. We report first evidence
Autor:
William E. Grizzle, Wenyan Lu, Bing Zhu, Yaguang Xi, Joel Andrews, Brian T. Eberhardt, Nan Li, Alexandra M. Fajardo, Sara Sigler, Yonghe Li, Veronica Ramirez-Alcantara, Suzanne Russo, Danuel J. Laan, Meagan Thomas, Joshua Canzoneri, Bernard D. Gary, Xi Chen, Evrim Gurpinar, Larry Yet, Gary A. Piazza, Mary Pat Moyer, Kevin Lee, Adam B. Keeton, John T. Piazza
Publikováno v:
Molecular Cancer Therapeutics. 12:C182-C182
Previous studies report that induction of intracellular cGMP can selectively inhibit proliferation and induce apoptosis of tumor cells. However, the phosphodiesterase (PDE) isozymes responsible for regulating cGMP in tumor cells or the basis for this