Zobrazeno 1 - 10 of 24 pro vyhledávání: '"John T Mondick"'
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Akademický článek
Bayesian modeling and simulation to inform rare disease drug development early decision-making: Application to Duchenne muscular dystrophy.
Autor: Janelle L Lennie, John T Mondick, Marc R Gastonguay
Publikováno v: PLoS ONE, Vol 17, Iss 4, p e0247286 (2022)
Rare disease clinical trials are constrained to small sample sizes and may lack placebo-control, leading to challenges in drug development. This paper proposes a Bayesian model-based framework for early go/no-go decision making in rare disease drug d
Externí odkaz: https://doaj.org/article/0abb8457e9e84dfda4ac392345ed3d5a
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2
Population Pharmacokinetic-Pharmacodynamic Modeling of Variable Wear Times for a Dextroamphetamine Transdermal System
Autor: Mariacristina Castelli, Marina Komaroff, Suzanne Meeves, Kanan Balakrishnan, Kyle T. Baron, John T. Mondick, Stephen V. Faraone, Gregory W. Mattingly
Publikováno v: CNS Spectrums. 28:246-246
IntroductionThe Dextroamphetamine Transdermal System (d-ATS) was developed as an alternative to oral amphetamine (AMP) formulations for ADHD. In a pivotal study, d-ATS met primary and secondary efficacy endpoints for ADHD in children and adolescents.
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::0bf55ee67c3e5b388f9de829bb8c0839
https://doi.org/10.1017/s1092852923001827
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3
Latent process model of the 6-minute walk test in Duchenne muscular dystrophy
Autor: Janelle L. Lennie, John T. Mondick, Marc R. Gastonguay
Publikováno v: Journal of Pharmacokinetics and Pharmacodynamics. 47:91-104
Duchenne muscular dystrophy (DMD) is a rare X-linked genetic pediatric disease characterized by a lack of functional dystrophin production in the body, resulting in muscle deterioration. Lower body muscle weakness progresses to non-ambulation typical
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::689e539a60871322ecf51d07e8aae02b
https://doi.org/10.1007/s10928-020-09671-7
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5
Bayesian modeling and simulation to inform rare disease drug development early decision-making: Application to Duchenne muscular dystrophy
Autor: Marc R. Gastonguay, Janelle L. Lennie, John T. Mondick
Publikováno v: PLOS ONE. 17:e0247286
Rare disease clinical trials are constrained to small sample sizes and may lack placebo-control, leading to challenges in drug development. This paper proposes a Bayesian model-based framework for early go/no-go decision making in rare disease drug d
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c1c6fb40390e728cb86cb86f72759d8b
https://doi.org/10.1371/journal.pone.0247286
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7
Population Pharmacokinetic- Pharmacodynamic Analysis to Characterize the Effect of Empagliflozin on Renal Glucose Threshold in Patients With Type 1 Diabetes Mellitus
Autor: Nima Soleymanlou, Matthew M. Riggs, John T. Mondick, Stefan Kaspers, Jan Marquard, Valerie Nock
Publikováno v: Journal of clinical pharmacology. 58(5)
Sodium glucose cotransporter 2 inhibitors increase urinary glucose excretion (UGE) by lowering the renal threshold for glucose (RTG ). We aimed to quantify the effect of the sodium glucose cotransporter inhibitor empagliflozin on renal glucose reabso
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4b301e76489b6d23f0ced5ddd6e884e8
https://pubmed.ncbi.nlm.nih.gov/29251772
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8
Delayed Small Bowel Transit in Children With Cystic Fibrosis and Pancreatic Insufficiency
Autor: Joan I. Schall, Maria R. Mascarenhas, John T. Mondick, Alisha J. Rovner, Hongming Zhuang
Publikováno v: Journal of Pediatric Gastroenterology & Nutrition. 57:81-84
OBJECTIVE Gastrointestinal disturbances are common in people with cystic fibrosis (CF); however, motility studies in this population have yielded inconsistent results. This study examined gastric emptying (GE) and small bowel transit (SBT) time in ch
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cb8b38e69b0e189d7b5b334ce3f2d05b
https://doi.org/10.1097/mpg.0b013e318290d112
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9
Diagnosing malabsorption with systemic lipid profiling: pharmacokinetics of pentadecanoic acid and triheptadecanoic acid following oral administration in healthy subjects and subjects with cystic fibrosis
Autor: Maria R. Mascarenhas, John T. Mondick, Jeffrey S. Barrett, Martha D. Wilson, Virginia A. Stallings, Joan I. Schall
Publikováno v: International Journal of Clinical Pharmacology and Therapeutics
Objective: A Malabsorption Blood Test (MBT) is proposed as an alternative method to the 72-hour stool and dietary collection for assessing the degree of fat malabsorption in people with pancreatic insufficiency. The MBT consists of a simultaneous ora
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::54a278359e8a1cc98f811cb02fde5c85
http://europepmc.org/articles/PMC4350154
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10
Population Pharmacokinetics of the Selective Serotonin 5-HT1A Receptor Partial Agonist Piclozotan
Autor: Tomomichi Fujitani, Charles Oo, Dimple Patel, John T. Mondick, Jeffrey S. Barrett, Kahori Shimizu
Publikováno v: American Journal of Therapeutics. 16:106-115
Background/Aims: Serotonin (5-HT) and its receptors are known to play important roles in various physiological and pathophysiological processes. The 5-HT 1A receptor subtype is thought to be involved in psychiatric disorders, immunomodulation, and in
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7f8e8561cffe3473ffd895b9dc98b0a6
https://doi.org/10.1097/mjt.0b013e31816b8c85
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