Zobrazeno 1 - 10
of 47
pro vyhledávání: '"John T Melchior"'
Autor:
Esmond N Geh, Debi K Swertfeger, Hannah Sexmith, Anna Heink, Pheruza Tarapore, John T Melchior, W Sean Davidson, Amy Sanghavi Shah
Publikováno v:
PLoS ONE, Vol 19, Iss 1, p e0291632 (2024)
BackgroundThe binding of low-density lipoprotein (LDL) to proteoglycans (PGs) in the extracellular matrix (ECM) of the arterial intima is a key initial step in the development of atherosclerosis. Although many techniques have been developed to assess
Externí odkaz:
https://doaj.org/article/2cb8a7279bc44d1db8bf66197b6880e3
Autor:
Jessica G. Woo, John T. Melchior, Debi K. Swertfeger, Alan T. Remaley, Ebrima A. Sise, Fatou Sosseh, Jeffrey A. Welge, Andrew M. Prentice, W. Sean Davidson, Sophie E. Moore, Laura A. Woollett
Publikováno v:
Lipids in Health and Disease, Vol 22, Iss 1, Pp 1-12 (2023)
Abstract Background Lipoprotein subfraction concentrations have been shown to change as gestation progresses in resource-rich settings. The objective of the current study was to evaluate the impact of pregnancy on different-sized lipoprotein particle
Externí odkaz:
https://doaj.org/article/702dcf393a3a45b7ba1c7e29b250bfc0
Autor:
John T. Melchior, Scott E. Street, Tomas Vaisar, Rachel Hart, Jay Jerome, Zsuzsanna Kuklenyik, Noemie Clouet-Foraison, Carissa Thornock, Shimpi Bedi, Amy S. Shah, Jere P. Segrest, Jay W. Heinecke, W. Sean Davidson
Publikováno v:
Journal of Lipid Research, Vol 62, Iss , Pp 100099- (2021)
Human high-density lipoproteins (HDLs) are a complex mixture of structurally related nanoparticles that perform distinct physiological functions. We previously showed that human HDL containing apolipoprotein A-I (APOA1) but not apolipoprotein A-II (A
Externí odkaz:
https://doaj.org/article/7ba703fa36364086ac73b700fa50b5e4
Autor:
John T. Melchior, Debi K. Swertfeger, Jamie Morris, Scott E. Street, Carri R. Warshak, Jeffrey A. Welge, Alan T. Remaley, Janet M. Catov, W. Sean Davidson, Laura A. Woollett
Publikováno v:
Journal of Lipid Research, Vol 62, Iss , Pp 100107- (2021)
Pregnancy is accompanied by significant physiological changes, which can impact the health and development of the fetus and mother. Pregnancy-induced changes in plasma lipoproteins are well documented, with modest to no impact observed on the generic
Externí odkaz:
https://doaj.org/article/5826d53782b841698497b93ac7f63d14
Autor:
Allison L. Cooke, Jamie Morris, John T. Melchior, Scott E. Street, W.Gray Jerome, Rong Huang, Andrew B. Herr, Loren E. Smith, Jere P. Segrest, Alan T. Remaley, Amy S. Shah, Thomas B. Thompson, W.Sean Davidson
Publikováno v:
Journal of Lipid Research, Vol 59, Iss 7, Pp 1244-1255 (2018)
APOA1 is the most abundant protein in HDL. It modulates interactions that affect HDL';s cardioprotective functions, in part via its activation of the enzyme, LCAT. On nascent discoidal HDL, APOA1 comprises 10 α-helical repeats arranged in an anti-pa
Externí odkaz:
https://doaj.org/article/60cd0651eb994e51bcbbc5b9d090567b
Autor:
W. Sean Davidson, Anna Heink, Hannah Sexmith, Lawrence M. Dolan, Scott M. Gordon, James D. Otvos, John T. Melchior, Deborah A. Elder, Jane Khoury, Esmond Geh, Amy S. Shah
Publikováno v:
Journal of Lipid Research, Vol 58, Iss 9, Pp 1916-1923 (2017)
We aimed to determine the risk factors associated with the depletion of large HDL particles and enrichment of small HDL particles observed in adolescents with T2D. Four groups of adolescents were recruited: 1) lean insulin-sensitive (L-IS), normal BM
Externí odkaz:
https://doaj.org/article/fbe4b4dc3f6b45dc95bdace0f1356e5b
Autor:
Cesar M. Rueda, Ana Lucia Rodríguez-Perea, Maria Moreno-Fernandez, Courtney M. Jackson, John T. Melchior, W. Sean Davidson, Claire A. Chougnet
Publikováno v:
Journal of Lipid Research, Vol 58, Iss 8, Pp 1514-1523 (2017)
HDLs appear to affect regulatory T cell (Treg) homeostasis, as suggested by the increased Treg counts in HDL-treated mice and by the positive correlation between Treg frequency and HDL-cholesterol levels in statin-treated healthy adults. However, the
Externí odkaz:
https://doaj.org/article/fb5d3b0d075e48368e9c428ad224be92
Autor:
John T. Melchior, Scott E. Street, Allison B. Andraski, Jeremy D. Furtado, Frank M. Sacks, Rebecca L. Shute, Emily I. Greve, Debi K. Swertfeger, Hailong Li, Amy S. Shah, L. Jason Lu, W. Sean Davidson
Publikováno v:
Journal of Lipid Research, Vol 58, Iss 7, Pp 1374-1385 (2017)
HDLs are a family of heterogeneous particles that vary in size, composition, and function. The structure of most HDLs is maintained by two scaffold proteins, apoA-I and apoA-II, but up to 95 other “accessory” proteins have been found associated w
Externí odkaz:
https://doaj.org/article/9bdda5dc5d85450a893725b39c9da318
Autor:
W. Sean Davidson, Anna Heink, Hannah Sexmith, John T. Melchior, Scott M. Gordon, Zsuzsanna Kuklenyik, Laura Woollett, John R. Barr, Jeffrey I. Jones, Christopher A. Toth, Amy S. Shah
Publikováno v:
Journal of Lipid Research, Vol 57, Iss 4, Pp 674-686 (2016)
HDL cholesterol (HDL-C) efflux function may be a more robust biomarker of coronary artery disease risk than HDL-C. To study HDL function, apoB-containing lipoproteins are precipitated from serum. Whether apoB precipitation affects HDL subspecies comp
Externí odkaz:
https://doaj.org/article/9612c5b2e1bc47a9acb7ba3e331f0534
Autor:
Soumyadeep Sarkar, John T. Melchior, Hayden R. Henry, Farooq Syed, Raghavendra G. Mirmira, Ernesto S. Nakayasu, Thomas O. Metz
Publikováno v:
Expert Opin Ther Targets
INTRODUCTION: Current treatment for Type 1 diabetes (T1D) is centered around insulin supplementation to manage the effects of pancreatic β cell loss. GDF15 is a potential preventative therapy against T1D progression that could work to curb increasin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b9d36177c78643e07463e1c62091d1b2
https://doi.org/10.1080/14728222.2022.2029410
https://doi.org/10.1080/14728222.2022.2029410