Výsledky vyhledávání - "John T Edward"

Assisted hydrolysis of cis-2-(3-phenylthioureido)cyclo pentane-carbonitrile in alkaline solution. Solvent dependent switch from hydrolysis to rearrangement of the iminothiooxopyrimidine intermediate

Autor: Ergun Atay, Iva B Blagoeva, Francis L Chubb, John T Edward, Ivan G Pojarlieff, Maria M Toteva

Publikováno v: Canadian Journal of Chemistry. 78:84-94

The cis and trans isomers of 2-(3-phenylthioureido)cyclopentanecarbonitrile, 1, and the respective carboxamides, 3, and acids, 4, have been prepared. Acid cyclization of both nitriles, faster with the cis isomer, gave the more stable cis-2-thiooxo-cy

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::e0ede91c9c2d599991408661aac7a714
https://doi.org/10.1139/v99-216

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Cage peroxides having planar bridgehead nitrogen atoms

Autor: Rosemary C. Hynes, Francis L. Chubb, Alain Wiesenthal, Françoise Sauriol, Denis F. R. Gilson, John T. Edward

Publikováno v: Canadian Journal of Chemistry. 77:1057-1065

Three new cage peroxides, 1,6-diaza-3,4,8,9-tetraoxabicyclo[4.4.2]dodecane (3a),1,6-diaza-3,4,8,9-tetraoxa-11-methylbicyclo[4.4.2]dodecane (3b), and 1,6-diaza-3,4,8,9-tetraoxatricyclo[4.4.2.411,12]hexadecane (4), have been prepared by reaction of 1,2

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::48e3d0e08311d683b9032ca33fca2f34
https://doi.org/10.1139/cjc-77-5-6-1057

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Calculation of octanol-water partition coefficients of organic solutes from their molecular volumes

Autor: John T. Edward

Publikováno v: Canadian Journal of Chemistry. 76:1294-1303

Bodor and Buchwald (8) have produced a two-parameter equation for calculating the logarithm of the partition coefficient (log P) of an organic solute between n-octanol and water. They computed the first parameter, a van der Waals volume of the of the

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::54d1e42e9dc13a84192c3b94ad788f40
https://doi.org/10.1139/v98-162

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Reexamination of the Kirkwood–Westheimer theory of electrostatic effects. V. Effect of charged substituents on the rates of alkaline hydrolysis of substituted strychnines

Autor: Phillip Hurst, Khamis A. Abbas, John T. Edward

Publikováno v: Canadian Journal of Chemistry. 75:441-448

The rates of hydrolysis in aqueous sodium hydroxide of the alkaloid strychnine and seven of its derivatives have been determined at 50 and 75 °C. The kinetic data indicate that all the compounds, except strychninesulfoni acid-I, hydrolyze by competi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::de287457a1b13e32cb480411f97d95ef
https://doi.org/10.1139/v97-050

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[Untitled]

Autor: John T. Edward

Publikováno v: BioMetals. 11:203-205

Pyridoxal isonicotinoyl hydrazone (PIH), salicylaldehydebenzoyl hydrazone (SBH), and their analogschelate iron(III) and show promise asorally effective drugs for treating diseases of iron overload. Theirbiological activity isrelated to their lipophil

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::4b7fb4ed2cd60569d4c651a422583498
https://doi.org/10.1023/a:1009264421478

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Iron chelators of the pyridoxal isonicotinoyl hydrazone class. Relationship of the lipophilicity of the apochelator to its ability to mobilise iron from reticulocytes in vitro

Autor: John T. Edward, Prem Ponka, Des R. Richardson, Francis L. Chubb

Publikováno v: Canadian journal of physiology and pharmacology. 72(6)

Analogues of the iron (III) chelator, pyridoxal isonicotinoyl hydrazone (PIH) show high potential as orally active agents for the treatment of iron-overload diseases, such as thalassemia. In the present study, the n-octanol–water partition coeffici

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ca102d58ce3bd5a7339905e689d292aa
https://pubmed.ncbi.nlm.nih.gov/7954097

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Anomeric Effect

Autor: John T. Edward

Publikováno v: ACS Symposium Series ISBN: 9780841227293
The Anomeric Effect and Associated Stereoelectronic Effects

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::79f12acbf9aaff9b850a71159f968759
https://doi.org/10.1021/bk-1993-0539.ch001

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Erratum: Assisted hydrolysis of cis-2-(3-phenylthioureido)cyclopentane-carbonitrile in alkaline solution. Solvent dependent switch from hydrolysis to rearrangement of the iminothiooxopyrimidine intermediate

Autor: Maria M. Toteva, Iva B. Blagoeva, Francis L. Chubb, Ergun Atay, Ivan G. Pojarlieff, John T. Edward

Publikováno v: Canadian Journal of Chemistry. 78:520

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::5669b09f5c466cf389fb91853ba53c2f
https://doi.org/10.1139/v00-069

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