Zobrazeno 1 - 10
of 112
pro vyhledávání: '"John T, Pinto"'
Publikováno v:
Biology, Vol 12, Iss 8, p 1131 (2023)
Many cancers utilize l-glutamine as a major energy source. Often cited in the literature as “l-glutamine addiction”, this well-characterized pathway involves hydrolysis of l-glutamine by a glutaminase to l-glutamate, followed by oxidative deamina
Externí odkaz:
https://doaj.org/article/d436fd1a7c01420ea85255ba6945d165
Publikováno v:
Frontiers in Medicine, Vol 13 (2022)
Externí odkaz:
https://doaj.org/article/172256bce7f8485785f6572811663d4b
Autor:
Amit Kumar, Manisha Vaish, Saravanan S Karuppagounder, Irina Gazaryan, John W Cave, Anatoly A Starkov, Elizabeth T Anderson, Sheng Zhang, John T Pinto, Austin M Rountree, Wang Wang, Ian R Sweet, Rajiv R Ratan
Publikováno v:
eLife, Vol 10 (2021)
Hypoxic adaptation mediated by HIF transcription factors requires mitochondria, which have been implicated in regulating HIF1α stability in hypoxia by distinct models that involve consuming oxygen or alternatively converting oxygen into the second m
Externí odkaz:
https://doaj.org/article/5101dfdcd63d48c8a22c4fac2e9e0afc
Autor:
Rajiv R. Ratan, Manisha Vaish, Ian R. Sweet, Anatoly A. Starkov, Amit Kumar, Sheng Zhang, Irina G. Gazaryan, John T. Pinto, Saravanan S. Karuppagounder, John W. Cave, Elizabeth T Anderson, Wang Wang, Austin M. Rountree
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e1fe54fe978547fbdd344fcc2e8e5f3a
https://doi.org/10.7554/elife.72873.sa2
https://doi.org/10.7554/elife.72873.sa2
Publikováno v:
Analytical Biochemistry. 644:114084
The asparaginase II pathway consists of an asparagine transaminase [ l -asparagine + α-keto acid ⇆ α-ketosuccinamate + l -amino acid] coupled to ω-amidase [α-ketosuccinamate + H2O → oxaloacetate + NH4+]. The net reaction is: l -asparagine +
Publikováno v:
Analytical Biochemistry. 644:114083
In rapidly dividing cells, including many cancer cells, l -glutamine is a major energy source. Utilization of glutamine is usually depicted as: l -glutamine → l -glutamate (catalyzed by glutaminase isozymes; GLS1 and GLS2), followed by l -glutamate
Autor:
Victor M. Darley-Usmar, Giovanni Coppola, Domenico Praticò, Rajiv R. Ratan, Lauren Alin, Cassandra M. Wilkinson, Megan W. Bourassa, Stephanie C. Sanchez, David Brand, Amit Kumar, Frederick Colbourne, Theodore R. Holman, S. Thomas Carmichael, Saravanan S. Karuppagounder, Ginger L. Milne, Colby A. Nadeau, Yingxin Chen, John T. Pinto, Kristen Dietrich, Steve Perry
Publikováno v:
Annals of Neurology. 84:854-872
Author(s): Karuppagounder, Saravanan S; Alin, Lauren; Chen, Yingxin; Brand, David; Bourassa, Megan W; Dietrich, Kristen; Wilkinson, Cassandra M; Nadeau, Colby A; Kumar, Amit; Perry, Steve; Pinto, John T; Darley-Usmar, Victor; Sanchez, Stephanie; Miln
Autor:
Irina G. Gazaryan, Austin M. Rountree, Ian R. Sweet, John W. Cave, Elizabeth T Anderson, John T. Pinto, Anatoly A. Starkov, Amit Kumar, Sheng Zhang, Saravanan S. Karuppagounder, Weisheng Wang, Manisha Vaish, Rajiv R. Ratan
Hypoxic adaptation mediated by HIF transcription factors has been shown to require mitochondria. Current models suggest that mitochondria regulate oxygen sensor (HIF prolyl hydroxylase) activity and HIF1α stability during hypoxia by either increasin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5190977daa6926248d6e89ba29e8d479
https://doi.org/10.1101/2020.05.05.079681
https://doi.org/10.1101/2020.05.05.079681
Publikováno v:
Biomolecules
Volume 10
Issue 1
Volume 10
Issue 1
Many tumors readily convert l-glutamine to &alpha
ketoglutarate. This conversion is almost invariably described as involving deamidation of l-glutamine to l-glutamate followed by a transaminase (or dehydrogenase) reaction. However, mammalian tis
ketoglutarate. This conversion is almost invariably described as involving deamidation of l-glutamine to l-glutamate followed by a transaminase (or dehydrogenase) reaction. However, mammalian tis
Publikováno v:
Annals of the New York Academy of Sciences. 1418:80-94
The mechanisms underlying life span extension by sulfur amino acid restriction (SAAR) are unclear. Cysteine and methionine are essential for the biosynthesis of proteins and glutathione (GSH), a major redox buffer in the endoplasmic reticulum (ER). W