Zobrazeno 1 - 10
of 992
pro vyhledávání: '"John T, O'Brien"'
Autor:
Qing Qi, Feng Deng, Rebecca Sammon, Karen Ritchie, Graciela Muniz-Terrera, Ivan Koychev, Paresh Malhotra, Siobhan Hutchinson, David Robinson, John T. O’Brien, Craig W. Ritchie, Brian Lawlor, Lorina Naci
Publikováno v:
Alzheimer’s Research & Therapy, Vol 16, Iss 1, Pp 1-13 (2024)
Abstract Background Females have a higher age-adjusted incidence of Alzheimer’s Disease (AD) than males, even when accounting for longer lifespan and, therefore, stand to benefit the most from dementia prevention efforts. As exposure to many modifi
Externí odkaz:
https://doaj.org/article/f444f2acc06b4074945bd1073a5c08c6
Autor:
Gemma Greenfinch, Calum A. Hamilton, Paul C. Donaghy, Michael Firbank, Nicola A. Barnett, Louise Allan, George S. Petrides, John-Paul Taylor, John T. O'Brien, Alan J. Thomas
Publikováno v:
BJPsych Open, Vol 10 (2024)
The aim of this study was to determine whether there was a significant change in cardiac [123I]-metaiodobenzylguanidine uptake between baseline and follow-up in individuals with mild cognitive impairment with Lewy bodies (MCI-LB) who had normal basel
Externí odkaz:
https://doaj.org/article/e519faefdb544755935a18184234e2cc
Autor:
Elijah Mak, Robert I. Reid, Scott A. Przybelski, Timothy G. Lesnick, Christopher G. Schwarz, Matthew L. Senjem, Sheelakumari Raghavan, Prashanthi Vemuri, Clifford R. Jack, Hoon Ki Min, Manoj K. Jain, Toji Miyagawa, Leah K. Forsberg, Julie A. Fields, Rodolfo Savica, Jonathan Graff-Radford, David T. Jones, Hugo Botha, Erik K. St. Louis, David S. Knopman, Vijay K. Ramanan, Dennis W. Dickson, Neill R. Graff-Radford, Tanis J. Ferman, Ronald C. Petersen, Val J. Lowe, Bradley F. Boeve, John T. O’Brien, Kejal Kantarci
Publikováno v:
npj Parkinson's Disease, Vol 10, Iss 1, Pp 1-13 (2024)
Abstract Dementia with Lewy bodies (DLB) is a neurodegenerative condition often co-occurring with Alzheimer’s disease (AD) pathology. Characterizing white matter tissue microstructure using Neurite Orientation Dispersion and Density Imaging (NODDI)
Externí odkaz:
https://doaj.org/article/149702719cdf4981a0894fd359d25ace
Autor:
Samuel Gibbon, Audrey Low, Charlene Hamid, Megan Reid‐Schachter, Graciela Muniz‐Terrera, Craig W. Ritchie, Emanuele Trucco, Baljean Dhillon, John T. O'Brien, Thomas J. MacGillivray
Publikováno v:
Alzheimer’s & Dementia: Diagnosis, Assessment & Disease Monitoring, Vol 16, Iss 3, Pp n/a-n/a (2024)
Abstract INTRODUCTION We tested associations between two retinal measures (optic disc pallor, peripapillary retinal nerve fiber layer [pRNFL] thickness) and four magnetic resonance imaging markers of cerebral small vessel disease (SVD; lacunes, micro
Externí odkaz:
https://doaj.org/article/006d8ce2e61e4c85bb65cafe6f2ab547
Autor:
Ingrid Buller-Peralta, Sarah Gregory, Audrey Low, Maria-Eleni Dounavi, Katie Bridgeman, Georgios Ntailianis, Brian Lawlor, Lorina Naci, Ivan Koychev, Paresh Malhotra, John T. O’Brien, Craig W. Ritchie, Graciela Muniz-Terrera
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-11 (2024)
Abstract To date, there is a considerable heterogeneity of methods to score Allostatic Load (AL). Here we propose a comprehensive algorithm (ALCS) that integrates commonly used approaches to generate AL risk categories and assess associations to brai
Externí odkaz:
https://doaj.org/article/ccb535da1f184e7a9790aaf75a87d94a
Autor:
David J. Whiteside, Negin Holland, Kamen A. Tsvetanov, Elijah Mak, Maura Malpetti, George Savulich, P. Simon Jones, Michelle Naessens, Matthew A. Rouse, Tim D. Fryer, Young T. Hong, Franklin I. Aigbirhio, Eoin Mulroy, Kailash P. Bhatia, Timothy Rittman, John T. O’Brien, James B. Rowe
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-13 (2023)
Abstract There is extensive synaptic loss from frontotemporal lobar degeneration, in preclinical models and human in vivo and post mortem studies. Understanding the consequences of synaptic loss for network function is important to support translatio
Externí odkaz:
https://doaj.org/article/ab6733cf5df64638bd28121108e81c94
Autor:
Ellen V Backhouse, Lisa J Woodhouse, Fergus Doubal, Rosalind Brown, Philip M Bath, Terence J Quinn, Thompson Robinson, Hugh S Markus, Richard J McManus, John T O'Brien, David J Werring, Nikola Sprigg, Adrian Parry-Jones, Rhian M Touyz, Steven Williams, Yee-Haur Mah, Hedley Emsley, Joanna M Wardlaw
Publikováno v:
Cerebral Circulation - Cognition and Behavior, Vol 6, Iss , Pp 100255- (2024)
Introduction: Cognitive decline and mood disorders are two major concerns of people affected by stroke. The extent to which cognition and mood relate to or are independent of stroke severity and post-stroke dependency are unclear. We examined the ass
Externí odkaz:
https://doaj.org/article/269e2a22e8064bf1905bce2fc9fc505b
Autor:
Audrey Low, Maria A Prats-Sedano, James D Stefaniak, Elizabeth McKiernan, Stephen F Carter, Maria-Eleni Dounavi, Elijah Mak, Li Su, Olivia Stupart, Graciela Muniz-Terrera, Karen Ritchie, Craig W Ritchie, Hugh S Markus, John T O'Brien
Publikováno v:
Cerebral Circulation - Cognition and Behavior, Vol 6, Iss , Pp 100050- (2024)
Externí odkaz:
https://doaj.org/article/de9bf992c4b34557b34ad62e53015ba2
Autor:
Xiaobei Pan, Paul C. Donaghy, Gemma Roberts, Leonidas Chouliaras, John T. O’Brien, Alan J. Thomas, Amanda J. Heslegrave, Henrik Zetterberg, Bernadette McGuinness, Anthony P. Passmore, Brian D. Green, Joseph P. M. Kane
Publikováno v:
Frontiers in Aging Neuroscience, Vol 15 (2024)
BackgroundIn multifactorial diseases, alterations in the concentration of metabolites can identify novel pathological mechanisms at the intersection between genetic and environmental influences. This study aimed to profile the plasma metabolome of pa
Externí odkaz:
https://doaj.org/article/8aad56e5df91470bbb204ca5a316b750
Autor:
Benjamin Tari, Michael Ben Yehuda, Axel Anders Stefan Laurell, Karen Ritchie, Yves Dauvilliers, Craig W. Ritchie, Brian Lawlor, Lorina Naci, Graciela Muniz Terrera, Paresh Malhotra, Tam Watermeyer, Robert Dudas, Benjamin R. Underwood, John T. O'Brien, Vanessa Raymont, Ivan Koychev
Publikováno v:
Frontiers in Sleep, Vol 2 (2023)
IntroductionAs the global population ages, the economic, societal, and personal burdens associated with worsening cognition and dementia onset are growing. It is therefore becoming ever more critical to understand the factors associated with cognitiv
Externí odkaz:
https://doaj.org/article/2d15b9cf2cd0449aad098f70148ad5af