Zobrazeno 1 - 10
of 60
pro vyhledávání: '"John T, Kung"'
Autor:
Chuan-Chuan Huang, Hsiang-Hsuan Sung, Hsiu-Chuan Li, Shi-Chuen Miaw, John T. Kung, Min-Yuan Chou, Betty A. Wu-Hsieh
Publikováno v:
Frontiers in Immunology, Vol 14 (2023)
Specific anti-CD3 treatment is deemed to be a promising therapy for allograft rejection and type 1 diabetes (T1D). Fc receptor (FcR) reduced-binding antibodies, by avoiding adverse effects of Fc and FcR interaction, have good therapeutic potential. W
Externí odkaz:
https://doaj.org/article/e3da1c5589e2465696578dcf32b35bad
Autor:
Yo-Ping Lai, Lu-Cheng Kuo, Been-Ren Lin, Hung-Ju Lin, Chih-Yu Lin, Yi-Ting Chen, Pei-Wen Hsiao, Huan-Tsung Chang, Patrick Chow-In Ko, Hsiao-Chin Chen, Hsiang-Yu Chang, Jean Lu, Hong-Nerng Ho, Betty A. Wu-Hsieh, John T. Kung, Shu-Ching Chen
Publikováno v:
Communications Biology, Vol 4, Iss 1, Pp 1-12 (2021)
Lai et al. report that the immunosuppressive molecule CD73 is negatively regulated by CD28 costimulation during CD8+ T cell activation. Their study implicates a lack of CD28 costimulation renders CD8+ T cells immunosuppressive and less able to elimin
Externí odkaz:
https://doaj.org/article/5b062bd4e6884a5f96c38bd03af38f9e
Publikováno v:
Hepatology. 77:1486-1498
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::434e85a878c504788b137df50c2e83bc
https://doi.org/10.1002/hep.32788
https://doi.org/10.1002/hep.32788
Publikováno v:
Hepatology (Baltimore, Md.)REFERENCES.
Long-lasting immunological memory is the ultimate goal of vaccination. Homeostatic maintenance of memory CD8We engineered a genetically engineered mouse in which IL-15R complementary DNA (cDNA) had been inserted in-frame with lecithin-retinol acyltra
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::951a4c5a4949edf9c26d1a8ecec5dc2a
https://pubmed.ncbi.nlm.nih.gov/36106384
https://pubmed.ncbi.nlm.nih.gov/36106384
Autor:
Pei Wen Hsiao, Lu Cheng Kuo, Hong Nerng Ho, Betty A. Wu-Hsieh, Hung-Ju Lin, Chih Yu Lin, Huan Tsung Chang, Yi-Ting Chen, Jean Lu, Been Ren Lin, Hsiang Yu Chang, Yo-Ping Lai, Hsiao Chin Chen, Patrick Chow-In Ko, John T. Kung, Shu-Ching Chen
Publikováno v:
Communications Biology, Vol 4, Iss 1, Pp 1-12 (2021)
CD28 is required for T cell activation as well as the generation of CD4+Foxp3+ Treg. It is unclear, however, how CD28 costimulation affects the development of CD8+ T cell suppressive function. Here, by use of Hepa1.6.gp33 in vitro killing assay and B
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cd36e66cab53447bd95ebb9c4035121d
https://doaj.org/article/5b062bd4e6884a5f96c38bd03af38f9e
https://doaj.org/article/5b062bd4e6884a5f96c38bd03af38f9e
Publikováno v:
Biology, Vol 1, Iss 1, Pp 18-42 (2012)
Due to a mutation in the Foxp3 transcription factor, Scurfy mice lack regulatory T-cells that maintain self-tolerance of the immune system. They develop multi-organ inflammation (MOI) and die around four weeks old. The affected organs are skin, tail,
Externí odkaz:
https://doaj.org/article/ca555e2f6af24e7baebe08b715303d0f
Autor:
Yo-Ping, Lai, Lu-Cheng, Kuo, Been-Ren, Lin, Hung-Ju, Lin, Chih-Yu, Lin, Yi-Ting, Chen, Pei-Wen, Hsiao, Huan-Tsung, Chang, Patrick Chow-In, Ko, Hsiao-Chin, Chen, Hsiang-Yu, Chang, Jean, Lu, Hong-Nerng, Ho, Betty A, Wu-Hsieh, John T, Kung, Shu-Ching, Chen
Publikováno v:
Communications Biology
CD28 is required for T cell activation as well as the generation of CD4+Foxp3+ Treg. It is unclear, however, how CD28 costimulation affects the development of CD8+ T cell suppressive function. Here, by use of Hepa1.6.gp33 in vitro killing assay and B
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::5d05e70808a054362da1acb2e3c21631
https://pubmed.ncbi.nlm.nih.gov/34011962
https://pubmed.ncbi.nlm.nih.gov/34011962
Autor:
Yi-Ting Chen, John T. Kung
Publikováno v:
Journal of immunology (Baltimore, Md. : 1950). 204(12)
BCR-mediated tonic signaling is an indispensable requirement for the survival of follicular B (FOB) cells and Burkitt lymphoma (BL) cells. FOB cells of the I-A12% mutant mouse express unfolded protein response and are extremely short lived. Among the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8ab8b22becfcd40cf1713433e718754f
https://pubmed.ncbi.nlm.nih.gov/32376649
https://pubmed.ncbi.nlm.nih.gov/32376649
Autor:
Wendy W Hwang-Verslues, Wen-Hung Kuo, Po-Hao Chang, Chi-Chun Pan, Hsing-Hui Wang, Sheng-Ta Tsai, Yung-Ming Jeng, Jin-Yu Shew, John T Kung, Chung-Hsuan Chen, Eva Y-H P Lee, King-Jen Chang, Wen-Hwa Lee
Publikováno v:
PLoS ONE, Vol 4, Iss 12, p e8377 (2009)
Heterogeneity of cancer stem/progenitor cells that give rise to different forms of cancer has been well demonstrated for leukemia. However, this fundamental concept has yet to be established for solid tumors including breast cancer. In this communica
Externí odkaz:
https://doaj.org/article/3323c4450c444964a8e509f0fd555a88
Publikováno v:
The Journal of Immunology. 198:1928-1943
The development and activation of MHC class II (MHC-II)–restricted CD4+ T cells are distinct immunological processes that are strictly MHC-II–dependent. To address their relative dependence on MHC-II, we established a novel ENU-induced mutant mou
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0f1dd6f2e7a67fea841a071ca9efc0c7
https://doi.org/10.4049/jimmunol.1600967
https://doi.org/10.4049/jimmunol.1600967