Zobrazeno 1 - 10
of 259
pro vyhledávání: '"John T, Harty"'
Autor:
Brittany P. Todd, Zili Luo, Noah Gilkes, Michael S. Chimenti, Zeru Peterson, Madison R. Mix, John T. Harty, Thomas Nickl-Jockschat, Polly J. Ferguson, Alexander G. Bassuk, Elizabeth A. Newell
Publikováno v:
Acta Neuropathologica Communications, Vol 11, Iss 1, Pp 1-16 (2023)
Abstract Accumulating evidence suggests that type I interferon (IFN-I) signaling is a key contributor to immune cell-mediated neuropathology in neurodegenerative diseases. Recently, we demonstrated a robust upregulation of type I interferon-stimulate
Externí odkaz:
https://doaj.org/article/8c8d670c025e4719a03715fdbd6ee349
Autor:
Roger R Berton, Patrick W McGonagil, Isaac J Jensen, Tiffany K Ybarra, Gail A Bishop, John T Harty, Thomas S Griffith, Vladimir P Badovinac
Publikováno v:
PLoS Pathogens, Vol 19, Iss 10, p e1011720 (2023)
Sepsis, an amplified immune response to systemic infection, is characterized by a transient cytokine storm followed by chronic immune dysfunction. Consequently, sepsis survivors are highly susceptible to newly introduced infections, suggesting sepsis
Externí odkaz:
https://doaj.org/article/003cece2a6b74de48c7dbeb1d175f5a5
Autor:
Mariah Hassert, John T. Harty
Publikováno v:
Frontiers in Immunology, Vol 13 (2022)
Historically, the gold-standard benchmark for vaccine immunogenicity has been the induction of neutralizing antibodies detectable in the serum of peripheral blood. However, in recent years there has been a new appreciation for the mucosa as an import
Externí odkaz:
https://doaj.org/article/642971e968b54f499ce0a464bd587e11
Autor:
Lisa L. Drewry, John T. Harty
Publikováno v:
Virulence, Vol 11, Iss 1, Pp 159-169 (2020)
Malarial disease caused by Plasmodium parasites challenges the mammalian immune system with a delicate balancing act. Robust inflammatory responses are required to control parasite replication within red blood cells, which if unchecked, can lead to s
Externí odkaz:
https://doaj.org/article/ed25f218519843fb8eeb1e97a0716ef7
Autor:
Carson Bowers, Lisa Hancox, Kristen Peissig, Justine C. Shiau, Amélie Vantaux, Benoit Witkowski, Sivchheng Phal, Steven P. Maher, John T. Harty, Dennis E. Kyle, Samarchith P. Kurup
Publikováno v:
Pathogens, Vol 11, Iss 12, p 1487 (2022)
Malaria is a deadly disease caused by the parasite, Plasmodium, and impacts the lives of millions of people around the world. Following inoculation into mammalian hosts by infected mosquitoes, the sporozoite stage of Plasmodium undergoes obligate dev
Externí odkaz:
https://doaj.org/article/7681f67d916f4392a1baa9aed41e8e95
Autor:
Mitchell N. Lefebvre, Fionna A. Surette, Scott M. Anthony, Rahul Vijay, Isaac J. Jensen, Lecia L. Pewe, Lisa S. Hancox, Natalija Van Braeckel-Budimir, Stephanie van de Wall, Stina L. Urban, Madison R. Mix, Samarchith P. Kurup, Vladimir P. Badovinac, Noah S. Butler, John T. Harty
Publikováno v:
Cell Reports, Vol 37, Iss 5, Pp 109956- (2021)
Summary: Circulating memory CD8 T cell trafficking and protective capacity during liver-stage malaria infection remains undefined. We find that effector memory CD8 T cells (Tem) infiltrate the liver within 6 hours after malarial or bacterial infectio
Externí odkaz:
https://doaj.org/article/bd5f91fa19ff4eed920a3ac786cb0f9f
Autor:
Scott M Anthony, Natalija Van Braeckel-Budimir, Steven J Moioffer, Stephanie van de Wall, Qiang Shan, Rahul Vijay, Ramakrishna Sompallae, Stacey M Hartwig, Isaac J Jensen, Steven M Varga, Noah S Butler, Hai-Hui Xue, Vladimir P Badovinac, John T Harty
Publikováno v:
eLife, Vol 10 (2021)
Protective lung tissue-resident memory CD8+T cells (Trm) form after influenza A virus (IAV) infection. We show that IAV infection of mice generates CD69+CD103+and other memory CD8+T cell populations in lung-draining mediastinal lymph nodes (mLNs) fro
Externí odkaz:
https://doaj.org/article/9f4540e8586a46a7b09e4472166aed7e
Publikováno v:
The Journal of Immunology. 210:1305-1313
Production of IFN-γ by CD4 T cells is widely theorized to control Plasmodium parasite burden during blood-stage malaria. Surprisingly, the specific and crucial mechanisms through which this highly pleiotropic cytokine acts to confer protection again
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b1d1e60db1b059d22886913fea31d3da
https://doi.org/10.4049/jimmunol.2200899
https://doi.org/10.4049/jimmunol.2200899
Publikováno v:
The Journal of Immunology. 210:1025-1030
Although tissue resident memory T cells (TRM) in the lung confer robust protection against secondary influenza infection, their in vivo production of IFN-γ is unknown. In this study, using a mouse model, we evaluated production of IFN-γ by influenz
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::307e4d8a8629bb9fb1b33f56f4ba1690
https://doi.org/10.4049/jimmunol.2200931
https://doi.org/10.4049/jimmunol.2200931
Autor:
Ashley A. Brate, Alexander W. Boyden, Farah R. Itani, Lecia L. Pewe, John T. Harty, Nitin J. Karandikar
Publikováno v:
Journal of Translational Autoimmunity, Vol 2, Iss , Pp - (2019)
Multiple Sclerosis (MS) is an autoimmune demyelinating disease of the central nervous system (CNS). We have shown that CNS-specific CD8 T cells (CNS-CD8) possess a disease suppressive function in MS and its animal model, experimental autoimmune encep
Externí odkaz:
https://doaj.org/article/408c2373d59249829881bba8052b7687