Zobrazeno 1 - 10
of 20
pro vyhledávání: '"John Stellwagen"'
Autor:
Jessica Able, Benjamin C. Milgram, Loren Berry, Melanie Cooke, Liyue Huang, John Butler, Hongbing Huang, Violeta Yu, Kristin Taborn, John D. Roberts, Steven Altmann, Margaret Y. Chu-Moyer, John Yeoman, Jean Wang, Roman Shimanovich, Russell Graceffa, Matthew Weiss, Thomas Kornecook, Christopher P Ilch, Bryan D. Moyer, Christiane Boezio, Isaac E. Marx, Brian A. Sparling, Emily A. Peterson, Gwen Rescourio, Charles Kreiman, Elma Feric Bojic, Karina R. Vaida, Angel Guzman-Perez, Dawn Zhu, Hua Gao, Laurie B. Schenkel, Michael Jarosh, Hanh Nho Nguyen, Joseph Ligutti, Alessandro Boezio, Hakan Gunaydin, Daniel S. La, Thomas Dineen, Robert T. Fremeau, Robert S. Foti, Min-Hwa Jasmine Lin, Erin F. DiMauro, John Stellwagen
Publikováno v:
Journal of Medicinal Chemistry. 60:5990-6017
Because of its strong genetic validation, NaV1.7 has attracted significant interest as a target for the treatment of pain. We have previously reported on a number of structurally distinct bicyclic heteroarylsulfonamides as NaV1.7 inhibitors that demo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::bb6062704d531ce83c1a6122ecc44600
https://doi.org/10.1021/acs.jmedchem.6b01850
https://doi.org/10.1021/acs.jmedchem.6b01850
Publikováno v:
ACS Symposium Series ISBN: 9780841233980
ACS Symposium Series
ACS Symposium Series
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::882fb71d741e4e95923dd629515c61ac
https://doi.org/10.1021/bk-2018-1307.ch002
https://doi.org/10.1021/bk-2018-1307.ch002
Autor:
Ahmed F. Abdel-Magid, Jaan A. Pesti, Rajappa Vaidyanathan, Xin Linghu, Nicholas Wong, James F. Blake, John J. Gaudino, John G. Moffat, Steven M. Mennen, John Stellwagen, Ryan D. White, David A. Thaisrivongs, William J. Morris, Jack D. Scott, Harrie J. M. Gijsen, Jinguang Lin, Yannis Houpis, Ling Tong, Joseph A. Kozlowski, Louis-Charles Campeau, Jingjun Yin, Staffan Karlsson, Daniel Pettersen, Henrik Sörensen, Darren McKerrecher, Alan Steven, Fredrik Zetterberg, Carl-Johan Aurell, James W. Leahy, Sriram Naganathan, Denise L. Andersen, Neil G. Andersen, Stephen Lau
Autor:
Russell F, Graceffa, Alessandro A, Boezio, Jessica, Able, Steven, Altmann, Loren M, Berry, Christiane, Boezio, John R, Butler, Margaret, Chu-Moyer, Melanie, Cooke, Erin F, DiMauro, Thomas A, Dineen, Elma, Feric Bojic, Robert S, Foti, Robert T, Fremeau, Angel, Guzman-Perez, Hua, Gao, Hakan, Gunaydin, Hongbing, Huang, Liyue, Huang, Christopher, Ilch, Michael, Jarosh, Thomas, Kornecook, Charles R, Kreiman, Daniel S, La, Joseph, Ligutti, Benjamin C, Milgram, Min-Hwa Jasmine, Lin, Isaac E, Marx, Hanh N, Nguyen, Emily A, Peterson, Gwen, Rescourio, John, Roberts, Laurie, Schenkel, Roman, Shimanovich, Brian A, Sparling, John, Stellwagen, Kristin, Taborn, Karina R, Vaida, Jean, Wang, John, Yeoman, Violeta, Yu, Dawn, Zhu, Bryan D, Moyer, Matthew M, Weiss
Publikováno v:
Journal of medicinal chemistry. 60(14)
Because of its strong genetic validation, Na
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::b8ea84d65ab7dd59414c7bfc36426140
https://pubmed.ncbi.nlm.nih.gov/28324649
https://pubmed.ncbi.nlm.nih.gov/28324649
Autor:
Tara Renae Rheault, Kimberly N. Smitheman, Kimberly G. Petrov, Chao Han, George Adjabeng, Alex G. Waterson, Marc R. Arnone, Alastair J. King, David E. Uehling, Olivia W. Rossanese, Keith R. Hornberger, Scott Howard Dickerson, John Stellwagen, Cynthia M. Rominger, Robert A. Mook
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 21:4436-4440
A potent series of inhibitors against the B-RafV600E kinase have been developed that show excellent activity in cellular assays and good oral bioavailability in rats. The key structural features of the series are an arylsulfonamide headgroup, a thiaz
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::15c814f8930dd9b7f17ce5a15f5e5352
https://doi.org/10.1016/j.bmcl.2011.06.021
https://doi.org/10.1016/j.bmcl.2011.06.021
Autor:
Laurie S. Kane-Carson, Kimberly N. Smitheman, Chao Han, Alex G. Waterson, Marc R. Arnone, Olivia W. Rossanese, David E. Uehling, John Stellwagen, Keith R. Hornberger, Robert A. Mook, Scott Howard Dickerson, Katherine G. Moss, Alastair J. King, Kimberly G. Petrov, Sylvie Laquerre, Ganesh S. Moorthy, George Adjabeng, Tara Renae Rheault
Hyperactive signaling of the MAP kinase pathway resulting from the constitutively active B-Raf(V600E) mutated enzyme has been observed in a number of human tumors, including melanomas. Herein we report the discovery and biological evaluation of GSK21
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::87ece1513b9365faece7d7d536bde0c1
https://europepmc.org/articles/PMC4027516/
https://europepmc.org/articles/PMC4027516/
Autor:
Nancy C. Stellwagen, John Stellwagen
Publikováno v:
The Journal of Physical Chemistry. 99:4247-4251
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8763820ee2f9bbcfc990bf172a1cf196
https://doi.org/10.1021/j100012a054
https://doi.org/10.1021/j100012a054
Autor:
Patricia Merkel, Richard T. Lewis, Violeta Yu, Allison Drew, Steven Szilvassy, Karina Romero, Renee Emkey, Hao Chen, Douglas Saffran, Rachael L. Brake, Yohannes Teffera, Christiane Bode, Paul S. Andrews, Man Xu, Earl Moore, Deborah Choquette, John Stellwagen, Linda F. Epstein, Michele Potashman, Douglas A. Whittington
Publikováno v:
Journal of medicinal chemistry. 55(14)
A class of 2-acyliminobenzimidazoles has been developed as potent and selective inhibitors of anaplastic lymphoma kinase (ALK). Structure based design facilitated the rapid development of structure–activity relationships (SAR) and the optimization
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d34d413a43032e31fb137ad636dd6ccc
https://pubmed.ncbi.nlm.nih.gov/22734674
https://pubmed.ncbi.nlm.nih.gov/22734674
Autor:
Alan C. Cheng, Ti Cai, Barbara Grubinska, Daniel S. La, Tammy L. Bush, Yohannes Teffera, Joseph L. Kim, Christiane Boezio, Michele Potashman, Russell Graceffa, Erin L. Mullady, Paul S. Andrews, James R. Coats, Katrina W. Copeland, Alessandro Boezio, Emily A. Peterson, Richard T. Lewis, John Stellwagen, Jingzhou Liu, Deborah Choquette, Karina Romero, Adria E. Colletti, Shuyan Yi, Mary K. Stanton, Paul L. Shaffer, Michelle DuPont
Publikováno v:
Bioorganicmedicinal chemistry letters. 22(15)
mTOR is a critical regulator of cellular signaling downstream of multiple growth factors. The mTOR/PI3K/AKT pathway is frequently mutated in human cancers and is thus an important oncology target. Herein we report the evolution of our program to disc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::57b4513ddf80e3dd0091b6571268da1c
https://pubmed.ncbi.nlm.nih.gov/22765895
https://pubmed.ncbi.nlm.nih.gov/22765895
Autor:
Nancy C. Stellwagen, John Stellwagen
Publikováno v:
Biopolymers. 34:1259-1273
The transient electric birefringence of low electroendosmosis (LE) agarose gels oriented by pulsed unidirectional electric fields was described in detail in Part I [J. Stellwagen and N. C. Stellwagen (1994), Biopolymers, Vol. 34, p. 187]. Here, the b
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ec7e1a2a57448c3030f36e2d533f9aaf
https://doi.org/10.1002/bip.360340914
https://doi.org/10.1002/bip.360340914