Sesquiterpene-evoked phytochemical toxicity in PC12 neuronal cells reveals a variable degree of oxidative stress and alpha-tocopherol and glutathione-dependent protection

Autor: John Staton Laws III, Scott D. Smid

Publikováno v: Current Research in Toxicology, Vol 6, Iss , Pp 100144- (2024)

Phytochemicals are often promoted generally as antioxidants and demonstrate variable levels of reactive oxygen species (ROS) sequestration in vitro, which attributes to their neuroprotective bioactivity. Sesquiterpenes from cannabis and essential oil

Externí odkaz: https://doaj.org/article/aefb67f8c1f94e869803973c003d5e6d

Evaluating Cannabis sativa L.’s neuroprotection potential: From bench to bedside

Autor: Laws, John Staton, III, Smid, Scott D.

Publikováno v: In Phytomedicine December 2022 107

Cannabis terpenes display variable protective and anti-aggregatory actions against neurotoxic β amyloid in vitro: highlighting the protective bioactivity of α-bisabolol in motorneuronal-like NSC-34 cells

Autor: John Staton, Laws Iii, Srijan, Shrestha, Scott D, Smid

Publikováno v: NeuroToxicology. 90:81-87

Terpenes form a diverse class of naturally occurring chemicals ascribed various biological activities. Cannabis contains over 400 different terpenes of varying chemical complexity which may add to the known biological activities of phytocannabinoids

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::850f39c007850791ac9563c9620d7214
https://doi.org/10.1016/j.neuro.2022.03.001

Evaluating Cannabis sativa L.'s neuroprotection potential: From bench to bedside

Autor: John Staton Laws, Scott D. Smid

Publikováno v: Phytomedicine : international journal of phytotherapy and phytopharmacology. 107

Neurodegenerative diseases and dementia pose a global health challenge in an aging population, exemplified by the increasing incidence and prevalence of its most common form, Alzheimer's disease. Although several approved treatments exist for Alzheim

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c34e0a8feaa36a6362af0b5b361ae9b9
https://pubmed.ncbi.nlm.nih.gov/36209703

Contributors

Autor: Abate, C., Adeghate, Ernest, Afroze, Chowdhury Alfi, Ahmed, Md Nasir, Ahmed, Mohammed M., Anand, Rajsavi Singh, Armour, Mike, Askari, Vahid Reza, Azam, Md Nur Kabidul, Bahnson, Edward Moreira, Baradaran Rahimi, Vafa, Barr, Alasdair M., Boivin, Michael, Brown, Joshua, Budde, Henning, Camacho-Rivera, Marlene, Chen, Ye, Chesworth, Rose, Cheung, Chi Wai, Chmura, Stacey E., Christiansen, April L., Clark, Thomas M., Colabufo, N.A., Contino, M., Costi, Roberta, Crescioli, Giada, da Silva-Júnior, Rui Milton Patrício, del Río, Carmen, Di Santo, Roberto, Duffy, Bryan C., Dyck, Jason R.B., Echeverry, Carolina, Eurich, Dean T., Fagetti, Jimena, Feingold, Daniel, Feng, Hui, Fernández-Carballido, Ana, Feuerstein, Joseph D., Filho, Alberto Souza Sá, Firenzuoli, Fabio, Fraguas-Sánchez, Ana Isabel, Garcia-Cairasco, Norberto, García-Fuster, M. Julia, García-García, Fabio, Garg, Ayushi, Gengo, Fran M., Gliksberg, Or, Gómez-Nieto, Ricardo, González-Mariscal, Isabel, Götz, Marcus R, Gyamfi, Daniel, Hagerman, Randi, Hashiesh, Hebaallah Mamdouh, Hernandez-Ortega, Nicolas, Hesami, Mohsen, Imperatori, Claudio, Islam, Jessica Y., Jahan, Rownak, Jha, Niraj Kumar, Jiang, Jessica XR, Johnson, Devon, Jones, Andrew Maxwell Phineas, Judd, Christopher D., Karl, Tim, Kaur, Ramanpreet, Kaushal, Naveen, Khan, Maria, Kumar, Sanjay, Kumar, Ujendra, Laws, III, John Staton, Lazarini-Lopes, Willian, Lee, Cerina, Leonetti, F., Leszko, Magdalena, Li, Lingyun, Linher-Melville, Katja, Lo, Lindsay A., Lombardi, Niccolò, López, Dolores E., Lowin, Torsten, Lyzwinski, Lynnette Nathalie, MacCallum, Caroline A., Machado, Sergio, Madia, Valentina Noemi, Maggini, Valentina, Mattle, Anna G., McLemon, Erin, Mechoulam, Raphael, Mehmood, Ishrat, Memarzia, Arghavan, Müller-Vahl, Kirsten R., Muñoz, Eduardo, Murillo-Rodríguez, Eric, Muschett, Matthew, Musetti, Bruno, Ojha, Shreesh, Patel, Vinood B., Paul, Tridib K., Piasek, Adrianna Maria, Pistawka, Carly A., Preedy, Victor R., Purcell, Chad, Rahmatullah, Mohammed, Rajendram, Rajkumar, Ralyea, Jr., Christopher C., Raup-Konsavage, Wesley M., Reyes-Parada, Miguel, Rodriguez, Diane L., Rosenthal, Martha S., Sadek, Bassem, Saleh, Ruba A., Scorza, Cecilia, Sera, Leah, Servilha-Menezes, Gabriel, Sharma, Tanvi, Shirah, Bader H., Shrestha, Srijan, Sinclair, Justin, Singh, Gurmit, Singh, Sneha, Smid, Scott D., Snider-Adler, Melissa, Sobiepanek, Anna, Somvanshi, Rishi K., Stefanachi, A., Stevenson, Maximillian H., Szejko, Natalia, Tanco, Kimberson, Thomas, Shilu Deepa, Thomson, Leonor, Torres-Suárez, Ana Isabel, Torterolo, Pablo, Valverde, Olga, Vannacci, Alfredo, Viana-Torre, Gerardo, Vidot, Denise C., Vrana, Kent E., Winkler, Matthias, Wong, Stanley Sau-Ching, Yadollahpour, Ali, Yamamoto, Tetsuya

Publikováno v: In Medicinal Usage of Cannabis and Cannabinoids 2023:xxi-xxv