Zobrazeno 1 - 10
of 15
pro vyhledávání: '"John Smith Del Rosario"'
Autor:
Wenjuan Jiang, John Smith Del Rosario, Wesley Botello-Smith, Siyuan Zhao, Yi-chun Lin, Han Zhang, Jérôme Lacroix, Tibor Rohacs, Yun Lyna Luo
Publikováno v:
Communications Biology, Vol 4, Iss 1, Pp 1-14 (2021)
Mechanosensitive Piezo1 channels transduce mechanical stimuli into electrochemical signals. Jiang et al. show that due to the bending rigidity of the membrane, the overlap of neighboring Piezo1 footprints produces a flattening of the Piezo1 footprint
Externí odkaz:
https://doaj.org/article/260f5ac2fa9043ccbe7d6be853d3c43f
Autor:
Taylor ET Hughes, John Smith Del Rosario, Abhijeet Kapoor, Aysenur Torun Yazici, Yevgen Yudin, Edwin C Fluck III, Marta Filizola, Tibor Rohacs, Vera Y Moiseenkova-Bell
Publikováno v:
eLife, Vol 8 (2019)
Transient receptor potential vanilloid 5 (TRPV5) is a highly calcium selective ion channel that acts as the rate-limiting step of calcium reabsorption in the kidney. The lack of potent, specific modulators of TRPV5 has limited the ability to probe th
Externí odkaz:
https://doaj.org/article/a82f5f6720e94648810a1aa64e4d1450
Autor:
Jiwon Yi, Zachariah Bertels, John Smith Del Rosario, Allie J. Widman, Richard A. Slivicki, Maria Payne, Henry M. Susser, Bryan A. Copits, Robert W. Gereau
Publikováno v:
bioRxiv
Bradykinin is a peptide implicated in inflammatory pain in both humans and rodents. In rodent sensory neurons, activation of B1 and B2 bradykinin receptors induces neuronal hyperexcitability. Recent evidence suggests that human and rodent dorsal root
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::055c5691c74fd1c3fcb2b45ec1f1cdd5
https://doi.org/10.1101/2023.03.31.534820
https://doi.org/10.1101/2023.03.31.534820
Autor:
Yun Lyna Luo, John Smith Del Rosario, Yi-Chun Lin, Wenjuan Jiang, Jerome J. Lacroix, Wesley M. Botello-Smith, Siyuan Zhao, Tibor Rohacs, Han Zhang
Publikováno v:
Communications Biology
Communications Biology, Vol 4, Iss 1, Pp 1-14 (2021)
Communications Biology, Vol 4, Iss 1, Pp 1-14 (2021)
Mechanosensitive Piezo1 channels are essential mechanotransduction proteins in eukaryotes. Their curved transmembrane domains, called arms, create a convex membrane deformation, or footprint, which is predicted to flatten in response to increased mem
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1008518c1c458a22f3200e913861bcce
http://europepmc.org/articles/PMC7815867
http://europepmc.org/articles/PMC7815867
Autor:
Yun Lyna Luo, Siyuan Zhao, John Smith Del Rosario, Wenjuan Jiang, Jerome J. Lacroix, Yi-Chun Lin, Tibor Rohacs, Han Zhang, Wesley M. Botello-Smith
Force-sensing Piezo channels are essential to many aspects of vertebrate physiology. Activation of Piezo1 is facilitated by the presence of negative membrane lipids in the inner leaflet, such as phosphatidylinositol-4,5-bisphosphate (PIP2). Here, to
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4df8a907feb00cb98905a25c25797421
https://doi.org/10.1101/2020.03.12.988378
https://doi.org/10.1101/2020.03.12.988378
Autor:
Amrita Samanta, Abhijeet Kapoor, Tibor Rohacs, Vera Y. Moiseenkova-Bell, Marta Filizola, Z. Hong Zhou, Xu Han, Taylor E. T. Hughes, David T. Lodowski, Kevin W. Huynh, Sandip Basak, Seungil Han, John Smith Del Rosario, Aysenur Yazici, Sudha Chakrapani
Publikováno v:
Nature Structural & Molecular Biology. 25:53-60
The transient receptor potential vanilloid 5 (TRPV5) channel is a member of the transient receptor potential (TRP) channel family, which is highly selective for Ca2+, that is present primarily at the apical membrane of distal tubule epithelial cells
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::da0bbb9feb725081adc8ea97d33e8162
https://doi.org/10.1038/s41594-017-0009-1
https://doi.org/10.1038/s41594-017-0009-1
Autor:
Tibor Rohacs, Tooraj Mirshahi, Songxue Su, John Smith Del Rosario, Yevgen Yudin, Cassandra M. Hartle
Publikováno v:
EMBO Rep
Mechanically activated Piezo2 channels are key players in somatosensory touch, but their regulation by cellular signaling pathways is poorly understood. Dorsal root ganglion (DRG) neurons express a variety of G-protein-coupled receptors that modulate
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7a3a5832b6377096c61c5ed159b86149
https://pubmed.ncbi.nlm.nih.gov/32227462
https://pubmed.ncbi.nlm.nih.gov/32227462
Autor:
Yevgen Yudin, Tibor Rohacs, Aysenur Yazici, Taylor E. T. Hughes, Edwin C. Fluck, Abhijeet Kapoor, Marta Filizola, John Smith Del Rosario, Vera Y. Moiseenkova-Bell
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::81d4169afda887e96b94c1a3a7d1bdfe
https://doi.org/10.7554/elife.49572.042
https://doi.org/10.7554/elife.49572.042
Autor:
Aysenur Yazici, John Smith Del Rosario, Vera Y. Moiseenkova-Bell, Edwin C. Fluck, Abhijeet Kapoor, Yevgen Yudin, Tibor Rohacs, Taylor E. T. Hughes, Marta Filizola
Publikováno v:
eLife
eLife, Vol 8 (2019)
eLife, Vol 8 (2019)
Transient receptor potential vanilloid 5 (TRPV5) is a highly calcium selective ion channel that acts as the rate-limiting step of calcium reabsorption in the kidney. The lack of potent, specific modulators of TRPV5 has limited the ability to probe th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3e662e335caf539ac7839d8f02534e92
https://pubmed.ncbi.nlm.nih.gov/31647410
https://pubmed.ncbi.nlm.nih.gov/31647410
Autor:
Tibor Rohacs, Yun Lyna Luo, Siyuan Zhao, Wesley M. Botello-Smith, John Smith Del Rosario, Yi-Chun Lin, Wenjuan Jiang, Jerome J. Lacroix, Han Zhang
Publikováno v:
Biophysical Journal. 120:228a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7152f5886dc9c94d63d394b493555dac
https://doi.org/10.1016/j.bpj.2020.11.1518
https://doi.org/10.1016/j.bpj.2020.11.1518