Zobrazeno 1 - 9
of 9
pro vyhledávání: '"John Sinclair Lawrence Fowler"'
Autor:
Anne Maurin, John Sinclair Lawrence Fowler, Jérôme Thireau, M L Sola, Sylvain Richard, J.-Y. Le Guennec, Sebastien Jude, Pascal Champeroux, C Laigot
Publikováno v:
British Journal of Pharmacology. 173:601-612
Background and purpose Ventricular arrhythmias induced by human ether-a-go-go related gene (hERG; Kv 11.1 channel) blockers are a consequence of alterations in ventricular repolarisation in association with high-frequency (HF) oscillations, which act
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::864807a8520e5f035e06e546f946d974
https://doi.org/10.1111/bph.13391
https://doi.org/10.1111/bph.13391
Autor:
John Sinclair Lawrence Fowler, Sebastien Jude, Anne Maurin, J.-Y. Le Guennec, Pascal Champeroux, Sylvain Richard, Jérôme Thireau, C Laigot-Barbé, M L Sola
Publikováno v:
British Journal of Pharmacology
British Journal of Pharmacology, Wiley, 2015, 172 (11), pp.2878-2891. ⟨10.1111/bph.13093⟩
British Journal of Pharmacology, Wiley, 2015, 172 (11), pp.2878-2891. ⟨10.1111/bph.13093⟩
Background and Purpose The present study was undertaken to investigate an effect of dofetilide, a potent arrhythmic blocker of the voltage-gated K+ channel, hERG, on cardiac autonomic control. Combined with effects on ardiomyocytes, these properties
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d56cfcb589734580d87cd0ede5bc719c
http://europepmc.org/articles/PMC4439882
http://europepmc.org/articles/PMC4439882
Autor:
Eric Martel, Dominique Babuty, Anne Maurin, Christine Laigot, Sebastien Jude, Arnaud Laveissiere, Andrée-Anne Weyn-Marotte, Serge Richard, John Sinclair Lawrence Fowler, Pascal Champeroux
Publikováno v:
Journal of Pharmacological and Toxicological Methods. 68:166-174
Introduction Power spectral analysis of heart rate variability is a tool known to provide information of interest on the autonomic control of heart rate in human. However, its use and its conditions of application and interpretation for safety purpos
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::45461a8f332a1b16adcb3580c2170533
https://doi.org/10.1016/j.vascn.2013.02.005
https://doi.org/10.1016/j.vascn.2013.02.005
Autor:
Jean-Yves Le Guennec, Eric Martel, Pascal Champeroux, John Sinclair Lawrence Fowler, Karen Viaud, Serge Richard, Abdel Ilah El Amrani
Publikováno v:
British Journal of Pharmacology. 144:376-385
Torsade de Pointes (TdP) is a well-described major risk associated with various kinds of drugs. However, prediction of this risk is still uncertain both in preclinical and clinical trials. We tested 45 reference compounds on the model of isolated can
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c5e177754767c7e9c932bda45f4204fd
https://doi.org/10.1038/sj.bjp.0706070
https://doi.org/10.1038/sj.bjp.0706070
Autor:
Pascal Champeroux, C. Audeval-Gerard, C. Nivet, Serge Richard, John Sinclair Lawrence Fowler, A I. K. El Amrani
Publikováno v:
European Journal of Drug Metabolism and Pharmacokinetics. 25:227-230
Nonsteroidal anti-inflammatory drugs (NSAIDs) are commonly used by topical application in management of joint pain and inflammation. Little is known, however, about their pharmacokinetics, especially in the synovial compartment versus the plasma comp
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f3f2dff75e3313b1775fd9e95a6ec764
https://doi.org/10.1007/bf03192319
https://doi.org/10.1007/bf03192319
Autor:
Serge Richard, Jean-Yves Le Guennec, Aude Ouillé, Pascal Champeroux, Anne Maurin, John Sinclair Lawrence Fowler, Eric Martel
Publikováno v:
Journal of Pharmacological and Toxicological Methods
Journal of Pharmacological and Toxicological Methods, Elsevier, 2011, 63 (3), pp.269-278. ⟨10.1016/j.vascn.2011.01.001⟩
Journal of Pharmacological and Toxicological Methods, Elsevier, 2011, 63 (3), pp.269-278. ⟨10.1016/j.vascn.2011.01.001⟩
Introduction In a previous study, two electrophysiological patterns for torsadogenic drugs were characterised in the model of isolated canine Purkinje fibres from their respective effects on action potential. This study was designed to elucidate the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::741cbcad55e1bac58718fcf1652b0ca1
https://pubmed.ncbi.nlm.nih.gov/21224008
https://pubmed.ncbi.nlm.nih.gov/21224008
Autor:
Eric Martel, Aude Ouillé, Patricia Lala, John Sinclair Lawrence Fowler, Serge Richard, Anne Maurin, Jean-Yves Le Guennec, Sebastien Jude, Pascal Champeroux
Publikováno v:
Journal of Pharmacological and Toxicological Methods
Journal of Pharmacological and Toxicological Methods, Elsevier, 2010, 61 (3), pp.251-263. ⟨10.1016/j.vascn.2010.02.006⟩
Journal of Pharmacological and Toxicological Methods, Elsevier, 2010, 61 (3), pp.251-263. ⟨10.1016/j.vascn.2010.02.006⟩
Introduction QT interval assessment by telemetry has become one of the most useful models in testing strategies adopted for detection of drug induced QT prolongation in non-clinical safety pharmacology studies. This study reports experimental data sh
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d304e6846baf5069ad892bcba848f9b1
https://hal.umontpellier.fr/hal-01822227
https://hal.umontpellier.fr/hal-01822227
Autor:
Sebastien Jude, Patricia Lala, Pascal Champeroux, Anne Maurin, Marie Laure Sola, John Sinclair Lawrence Fowler, Andrée Anne Weyn, Eric Martel, Arnaud Laveissiere, Serge Richard, Francine El-Amrani
Publikováno v:
Journal of pharmacological and toxicological methods. 59(2)
Introduction Drug-induced QT interval prolongation is a major concern in new drug candidate development. This study presents a method of assessment of drug-induced QT interval prolongation without need for QT correction in conscious Beagle dogs and C
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8528843d9c7100627e15cd7d5d1f9af9
https://pubmed.ncbi.nlm.nih.gov/19135537
https://pubmed.ncbi.nlm.nih.gov/19135537
Autor:
Pascal Champeroux, Christine Laigot, John Sinclair Lawrence Fowler, Serge Richard, Anne Maurin, Sebastien Jude, Marie-Laure Sola
Publikováno v:
Journal of Pharmacological and Toxicological Methods. 75:179
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b8649589b27decb84b17590107053b5c
https://doi.org/10.1016/j.vascn.2015.08.072
https://doi.org/10.1016/j.vascn.2015.08.072