Zobrazeno 1 - 10
of 25
pro vyhledávání: '"John Simon WM"'
Publikováno v:
BMC Genomics, Vol 12, Iss 1, p 429 (2011)
Abstract Background We introduce Glaucoma Discovery Platform (GDP), an online environment for facile visualization and interrogation of complex transcription profiling datasets for glaucoma. We also report the availability of Datgan, the suite of scr
Externí odkaz:
https://doaj.org/article/91ff49f581d04f0f82d44a8a9c1b4600
Autor:
Mehalow Adrienne, Amonoo Leslie A, Nair K Saidas, Anderson Michael G, Trantow Colleen M, Masli Sharmila, John Simon WM
Publikováno v:
BMC Genetics, Vol 9, Iss 1, p 30 (2008)
Abstract Background The Gpnmb gene encodes a transmembrane protein whose function(s) remain largely unknown. Here, we assess if a mutant allele of Gpnmb confers susceptibility to glaucoma by altering immune functions. DBA/2J mice have a mutant Gpnmb
Externí odkaz:
https://doaj.org/article/f98190570dee447cb0dcdbb35439d0da
Autor:
Savinova Olga V, Pang Iok-Hou, Howell Gareth R, Libby Richard T, Mehalow Adrienne K, Barter Joseph W, Smith Richard S, Clark Abbot F, John Simon WM
Publikováno v:
BMC Neuroscience, Vol 8, Iss 1, p 108 (2007)
Abstract Background Nitric oxide synthase 2 (NOS2) contributes to neural death in some settings, but its role in glaucoma remains controversial. NOS2 is implicated in retinal ganglion cell degeneration in a rat glaucoma model in which intraocular pre
Externí odkaz:
https://doaj.org/article/99bc028c63b24cbfb0fe804ec4bf2c6f
Autor:
Wilson Lawriston A, Marchant Jeffrey K, Libby Richard T, Howell Gareth R, Cosma Ioan M, Smith Richard S, Anderson Michael G, John Simon WM
Publikováno v:
BMC Genetics, Vol 8, Iss 1, p 45 (2007)
Abstract Background The glaucomas are a common but incompletely understood group of diseases. DBA/2J mice develop a pigment liberating iris disease that ultimately causes elevated intraocular pressure (IOP) and glaucoma. We have shown previously that
Externí odkaz:
https://doaj.org/article/a46506c9455d45ac9564601aae8e4945
Autor:
Cosma Ioan M, Mao Mao, Libby Richard T, Anderson Michael G, Wilson Larry A, Smith Richard S, John Simon WM
Publikováno v:
BMC Biology, Vol 4, Iss 1, p 20 (2006)
Abstract Background DBA/2J (D2) mice develop an age-related form of glaucoma. Their eyes progressively develop iris pigment dispersion and iris atrophy followed by increased intraocular pressure (IOP) and glaucomatous optic nerve damage. Mutant allel
Externí odkaz:
https://doaj.org/article/1d6c107c0d3249da983ba05d0ba14f16
Autor:
Nusinowitz Steven, Zabaleta Adriana, Hawes Norman L, Savinova Olga V, Peters Maureen, Smith Richard S, Chang Bo, Martin Janice E, Davisson Muriel L, Cepko Constance L, Hogan Brigid LM, John Simon WM
Publikováno v:
BMC Genetics, Vol 2, Iss 1, p 18 (2001)
Abstract Background Glaucoma is a blinding disease usually associated with high intraocular pressure (IOP). In some families, abnormal anterior segment development contributes to glaucoma. The genes causing anterior segment dysgenesis and glaucoma in
Externí odkaz:
https://doaj.org/article/aceefd53c6f0435f8c95d93c025a0dfd
Autor:
Tomarev Stanislav I, Martin Janice E, Sugiyama Fumihiro, Savinova Olga V, Paigen Beverly J, Smith Richard S, John Simon WM
Publikováno v:
BMC Genetics, Vol 2, Iss 1, p 16 (2001)
Externí odkaz:
https://doaj.org/article/1c6da35fc54e40bf9b73b5e3e21f4672
Autor:
Zabaleta Adriana, Chang Bo, Hawes Norman L, Savinova Olga V, Smith Richard S, Anderson Michael G, Wilpan Robert, Heckenlively John R, Davisson Muriel, John Simon WM
Publikováno v:
BMC Genetics, Vol 2, Iss 1, p 1 (2001)
Abstract Background Glaucoma is a common disease but its molecular etiology is poorly understood. It involves retinal ganglion cell death and optic nerve damage that is often associated with elevated intraocular pressure. Identifying genes that modif
Externí odkaz:
https://doaj.org/article/004831d21664487fa5846712749dd06e
Autor:
Paylakhi, Seyyedhassan, Labelle-Dumais, Cassandre, Tolman, Nicholas G, Sellarole, Michael A., Seymens, Yusef, Saunders, Joseph, Lakosha, Hesham, deVries, Wilhelmine N., Orr, Andrew C., Topilko, Piotr, John, Simon WM., Nair, K. Saidas
Publikováno v:
PLoS Genetics; 3/12/2018, Vol. 14 Issue 3, p1-29, 29p
Autor:
Chang, Bo, Smith, Richard S, Peters, Maureen, Savinova, Olga V, Hawes, Norman L, Zabaleta, Adriana, Nusinowitz, Steven, Martin, Janice E, Davisson, Muriel L, Cepko, Constance L, Hogan, Brigid LM, John, Simon WM
Publikováno v:
BMC Genetics, Vol 2, Iss 1, p 18 (2001)
BMC Genetics
BMC Genetics
Background Glaucoma is a blinding disease usually associated with high intraocular pressure (IOP). In some families, abnormal anterior segment development contributes to glaucoma. The genes causing anterior segment dysgenesis and glaucoma in most of