Zobrazeno 1 - 10
of 58
pro vyhledávání: '"John Silk"'
Autor:
Yuhan Wang, Zijian Liu, Qian Si, Wanqiu Lu, Yuxian Song, Wanyong Jin, Xihu Yang, Zihui Li, Xinyang Hu, Liang Ding, Yue Jing, Pei Weng, Qiuya Yu, Lorraine A. O’Reilly, John Silke, Xiaoxin Zhang, Qingang Hu, Yanhong Ni
Publikováno v:
Cell Death and Disease, Vol 15, Iss 11, Pp 1-15 (2024)
Abstract Small molecule inhibitors of apoptosis proteins (IAPs) antagonists, known as Smac mimetics (SMs), activate non-canonical NF-κB and sensitize cancer cells to TNF-induced cell death. SMs are currently in phase III clinical trials for head and
Externí odkaz:
https://doaj.org/article/0c6e0f2270ec4dc6bc017b7e7e512e53
Autor:
Shene Chiou, Aysha H Al-Ani, Yi Pan, Komal M Patel, Isabella Y Kong, Lachlan W Whitehead, Amanda Light, Samuel N Young, Marilou Barrios, Callum Sargeant, Pradeep Rajasekhar, Leah Zhu, Anne Hempel, Ann Lin, James A Rickard, Cathrine Hall, Pradnya Gangatirkar, Raymond KH Yip, Wayne Cawthorne, Annette V Jacobsen, Christopher R Horne, Katherine R Martin, Lisa J Ioannidis, Diana S Hansen, Jessica Day, Ian P Wicks, Charity Law, Matthew E Ritchie, Rory Bowden, Joanne M Hildebrand, Lorraine A O’Reilly, John Silke, Lisa Giulino-Roth, Ellen Tsui, Kelly L Rogers, Edwin D Hawkins, Britt Christensen, James M Murphy, André L Samson
Publikováno v:
EMBO Molecular Medicine, Vol 16, Iss 7, Pp 1717-1749 (2024)
Abstract Necroptosis is a lytic form of regulated cell death reported to contribute to inflammatory diseases of the gut, skin and lung, as well as ischemic-reperfusion injuries of the kidney, heart and brain. However, precise identification of the ce
Externí odkaz:
https://doaj.org/article/3261c59629e24716b5f237cbc3d2531c
Autor:
John Silk
Even the Defeats is the story of how painful moments in Sir Alex Ferguson's early reign inspired him to lead Manchester United to some of their greatest successes. A heavy 5-1 loss at Manchester City in Ferguson's early tenure led pundits and support
Autor:
Sarah E. Garnish, Katherine R. Martin, Maria Kauppi, Victoria E. Jackson, Rebecca Ambrose, Vik Ven Eng, Shene Chiou, Yanxiang Meng, Daniel Frank, Emma C. Tovey Crutchfield, Komal M. Patel, Annette V. Jacobsen, Georgia K. Atkin-Smith, Ladina Di Rago, Marcel Doerflinger, Christopher R. Horne, Cathrine Hall, Samuel N. Young, Matthew Cook, Vicki Athanasopoulos, Carola G. Vinuesa, Kate E. Lawlor, Ian P. Wicks, Gregor Ebert, Ashley P. Ng, Charlotte A. Slade, Jaclyn S. Pearson, André L. Samson, John Silke, James M. Murphy, Joanne M. Hildebrand
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-17 (2023)
Abstract Across the globe, 2-3% of humans carry the p.Ser132Pro single nucleotide polymorphism in MLKL, the terminal effector protein of the inflammatory form of programmed cell death, necroptosis. Here we show that this substitution confers a gain i
Externí odkaz:
https://doaj.org/article/14198b0aa4ad4e93a3c3095f5a9f9cb4
Autor:
Ali I. Mohammed, Antonio Celentano, Rita Paolini, Jun T. Low, John Silke, Lorraine A. O’ Reilly, Michael McCullough, Nicola Cirillo
Publikováno v:
Cell Death and Disease, Vol 14, Iss 7, Pp 1-15 (2023)
Abstract Oral and intestinal mucositis (OIM) are debilitating inflammatory diseases initiated by oxidative stress, resulting in epithelial cell death and are frequently observed in cancer patients undergoing chemo-radiotherapy. There are currently fe
Externí odkaz:
https://doaj.org/article/cd2b4d575dd24192a1ab5d3578013524
Autor:
Destiny Dalseno, Holly Anderton, Andrew Kueh, Marco J Herold, John Silke, Andreas Strasser, Philippe Bouillet
Publikováno v:
Cell Death and Disease, Vol 14, Iss 3, Pp 1-9 (2023)
Abstract The cytokine TNF has essential roles in immune defence against diverse pathogens and, when its expression is deregulated, it can drive severe inflammatory disease. The control of TNF levels is therefore critical for normal functioning of the
Externí odkaz:
https://doaj.org/article/5e71f08ee1a54b03b4facdc1e3b04458
Autor:
Xiangyi S. Wang, Thomas R. Cotton, Sarah J. Trevelyan, Lachlan W. Richardson, Wei Ting Lee, John Silke, Bernhard C. Lechtenberg
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-17 (2023)
RBR E3 ubiquitin ligases utilise a 2-step catalytic mechanism previously defined for only few of the RBR family members. Here, the authors examine the poorly studied RBRs HOIL-1 and RNF216 to define general principles of RBR catalysis and regulation
Externí odkaz:
https://doaj.org/article/6df400b1fdfd4a3a9df0102e30295f9d
Autor:
Liang Ding, Yong Fu, Nisha Zhu, Mengxiang Zhao, Zhuang Ding, Xiaoxin Zhang, Yuxian Song, Yue Jing, Qian Zhang, Sheng Chen, Xiaofeng Huang, Lorraine A O’Reilly, John Silke, Qingang Hu, Yanhong Ni
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-19 (2022)
Worst pattern of invasion (WPOI) is a parameter used to quantify tumor invasiveness of oral squamous cell carcinoma (OSCC). Here the authors show that a fibroblast subset characterized by the expression of the oxytocin receptor is enriched in highly
Externí odkaz:
https://doaj.org/article/6e6d9888800e4dd9bbef668c7f176d48