Zobrazeno 1 - 10
of 98
pro vyhledávání: '"John Sembrat"'
Autor:
Marta Bueno, Jazmin Calyeca, Timur Khaliullin, Megan P. Miller, Diana Alvarez, Lorena Rosas, Judith Brands, Christian Baker, Amro Nasser, Stephanie Shulkowski, August Mathien, Nneoma Uzoukwu, John Sembrat, Brenton G. Mays, Kaitlin Fiedler, Scott A. Hahn, Sonia R. Salvatore, Francisco J. Schopfer, Mauricio Rojas, Peter Sandner, Adam C. Straub, Ana L. Mora
Publikováno v:
JCI Insight, Vol 8, Iss 5 (2023)
Type II alveolar epithelial cell (AECII) redox imbalance contributes to the pathogenesis of idiopathic pulmonary fibrosis (IPF), a deadly disease with limited treatment options. Here, we show that expression of membrane-bound cytochrome B5 reductase
Externí odkaz:
https://doaj.org/article/c430eef5b8e94876abbd6d496306422d
Autor:
Xiuying Li, Guillaume Noell, Tracy Tabib, Alyssa D. Gregory, Humberto E. Trejo Bittar, Ravi Vats, Tomasz W. Kaminski, John Sembrat, Mark E. Snyder, Divay Chandra, Kong Chen, Chunbin Zou, Yingze Zhang, Prithu Sundd, John F. McDyer, Frank Sciurba, Mauricio Rojas, Robert Lafyatis, Steve D. Shapiro, Rosa Faner, Toru Nyunoya
Publikováno v:
Respiratory Research, Vol 22, Iss 1, Pp 1-13 (2021)
Abstract Background Whole lung tissue transcriptomic profiling studies in chronic obstructive pulmonary disease (COPD) have led to the identification of several genes associated with the severity of airflow limitation and/or the presence of emphysema
Externí odkaz:
https://doaj.org/article/bdc04207348c4b6b870af02a41004215
Autor:
Nayra Cárdenes, John Sembrat, Kentaro Noda, Tyler Lovelace, Diana Álvarez, Humberto E. Trejo Bittar, Brian J. Philips, Mehdi Nouraie, Panayiotis V. Benos, Pablo G. Sánchez, Mauricio Rojas
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-13 (2021)
Abstract Experimental animal models to predict physiological responses to injury and stress in humans have inherent limitations. Therefore, the development of preclinical human models is of paramount importance. Ex vivo lung perfusion (EVLP) has typi
Externí odkaz:
https://doaj.org/article/8bc473a935524370bc235806f5fd1ab2
Autor:
Eleanor Valenzi, Tracy Tabib, Anna Papazoglou, John Sembrat, Humberto E. Trejo Bittar, Mauricio Rojas, Robert Lafyatis
Publikováno v:
Frontiers in Immunology, Vol 12 (2021)
Idiopathic pulmonary fibrosis (IPF) and systemic sclerosis-associated interstitial lung disease (SSc-ILD) differ in the predominant demographics and identified genetic risk alleles of effected patients, however both diseases frequently progress to re
Externí odkaz:
https://doaj.org/article/bc785957a44d45c49c778df6c7966fa8
Autor:
Nayra Cárdenes, Diana Álvarez, Jacobo Sellarés, Yating Peng, Catherine Corey, Sophie Wecht, Seyed Mehdi Nouraie, Swaroop Shanker, John Sembrat, Marta Bueno, Sruti Shiva, Ana L. Mora, Mauricio Rojas
Publikováno v:
Stem Cell Research & Therapy, Vol 9, Iss 1, Pp 1-10 (2018)
Abstract Background Idiopathic pulmonary fibrosis (IPF) is a chronic lung disease for which age is the most important risk factor. Different mechanisms associated with aging, including stem cell dysfunction, have been described to participate in the
Externí odkaz:
https://doaj.org/article/6230f5c898654922a0d6b4391110bfe5
Autor:
Didem Saygin, Tracy Tabib, Humberto E.T. Bittar, Eleanor Valenzi, John Sembrat, Stephen Y. Chan, Mauricio Rojas, Robert Lafyatis
Publikováno v:
Pulmonary Circulation, Vol 10 (2020)
Despite recent improvements in management of idiopathic pulmonary arterial hypertension, mortality remains high. Understanding the alterations in the transcriptome–phenotype of the key lung cells involved could provide insight into the drivers of p
Externí odkaz:
https://doaj.org/article/c495b32adbd1484f9428c8494067b877
PINK1 attenuates mtDNA release in alveolar epithelial cells and TLR9 mediated profibrotic responses.
Autor:
Marta Bueno, Daniel Zank, Ivette Buendia-Roldán, Kaitlin Fiedler, Brenton G Mays, Diana Alvarez, John Sembrat, Brian Kimball, Jordan K Bullock, James L Martin, Mehdi Nouraie, Brett A Kaufman, Mauricio Rojas, Annie Pardo, Moisés Selman, Ana L Mora
Publikováno v:
PLoS ONE, Vol 14, Iss 6, p e0218003 (2019)
We have previously shown that endoplasmic reticulum stress (ER stress) represses the PTEN inducible kinase 1 (PINK1) in lung type II alveolar epithelial cells (AECII) reducing mitophagy and increasing the susceptibility to lung fibrosis. Although inc
Externí odkaz:
https://doaj.org/article/68541fa065c84c808d41a0a0f14db3e0
Autor:
Sanghamitra Sahoo, Daniel N Meijles, Imad Al Ghouleh, Manuj Tandon, Eugenia Cifuentes-Pagano, John Sembrat, Mauricio Rojas, Elena Goncharova, Patrick J Pagano
Publikováno v:
PLoS ONE, Vol 11, Iss 5, p e0153780 (2016)
BACKGROUND:Vascular hyperproliferative disorders are characterized by excessive smooth muscle cell (SMC) proliferation leading to vessel remodeling and occlusion. In pulmonary arterial hypertension (PAH), SMC phenotype switching from a terminally dif
Externí odkaz:
https://doaj.org/article/6d9e90dddcb1477581c7f181d36ce920
Autor:
Ferhan Tuncer, Melissa Bulik, John Villandre, Travis Lear, Yanwen Chen, Beyza Tuncer, Daniel J. Kass, Eleanor Valenzi, Christina Morse, John Sembrat, Robert Lafyatis, Bill Chen, John Evankovich
Publikováno v:
American journal of physiology. Lung cellular and molecular physiology. 323(4)
Accumulation of excessive extracellular matrix (ECM) components from lung fibroblasts is a feature of systemic sclerosis-associated interstitial lung disease (SSc-ILD), and there is increasing evidence that innate immune signaling pathways contribute
Autor:
Anna Papazoglou, Mengqi Huang, Melissa Bulik, Annika Lafyatis, Tracy Tabib, Christina Morse, John Sembrat, Mauricio Rojas, Eleanor Valenzi, Robert Lafyatis
Publikováno v:
Arthritis & Rheumatology. 74:2003-2014
Systemic sclerosis-associated interstitial lung disease (SSc-ILD) is the leading cause of death in patients with SSc with unclear pathogenesis and limited treatment options. Evidence strongly supports an important role for profibrotic secreted phosph