Zobrazeno 1 - 10
of 12
pro vyhledávání: '"John Scopes"'
Autor:
John Scopes, Modupe O. Elebute, Frances M. Gibson, Edward C. Gordon-Smith, Sian Rizzo, Helen A. Papadaki
Publikováno v:
The Hematology Journal. 3:230-236
Aplastic anemia is associated with quantitative and functional abnormalities in the hematopoietic stem cell compartment. Currently, one of the most primitive human hematopoietic progenitor cells that can be functionally assayed in vitro is the long-t
Autor:
M. Ismail, John Scopes, Frances M. Gibson, Edward C. Gordon-Smith, Christopher Pocock, Karen J. Marks, T. R. Rutherford, Gwen S. Draycott
Publikováno v:
British Journal of Haematology. 115:642-652
Defects in stromal cell function have been demonstrated in a number of aplastic anaemia (AA) patients. Here we have studied a patient with severe AA and abnormal stromal cell function who underwent bone marrow transplantation (BMT). The objective of
Publikováno v:
British Journal of Haematology. 112:430-437
Osteoclasts form in the presence of macrophage colony-stimulating factor (M-CSF) and receptor activator of Nfkappab ligand (RANKL), a membrane-bound differentiation factor that is now available as a soluble recombinant molecule. Acquisition of the os
Autor:
Edward C. Gordon-Smith, Richard Atkinson, Frances M. Gibson, John Scopes, Sarah E. Ball, S. Daly
Publikováno v:
Blood. 87:3179-3185
We investigated the effects of granulocyte-macrophage colony- stimulating factor, interleukin-3, stem cell factor, interleukin-6, and granulocyte colony-stimulating factor (G-CSF) alone, and in combination, on the clonogenic potential of normal and a
Autor:
Edward C. Gordon-Smith, M. Westby, A. J. C. Turner, Frances M. Gibson, Angus G. Dalgleish, N. J. Philpott, Judith C. W. Marsh, John Scopes
Publikováno v:
Blood. 87:2244-2251
The detection and quantitation of apoptotic cells is becoming increasingly important in the investigation of the role of apoptosis in cellular proliferation and differentiation. The pathogenesis of hematologic disorders such as aplastic anemia and th
Publikováno v:
British Journal of Haematology. 91:551-561
Defective marrow stroma, or microenvironment, have been proposed as one of several mechanisms to account for bone marrow failure in aplastic anaemia (AA). This could involve defects in positive- or negative-acting haemopoietic regulator expression by
Autor:
Judith C. W. Marsh, A. S. J. Baughan, S. Daly, John Scopes, Frances M. Gibson, Z. H. Abboudi, Edward C. Gordon-Smith, D. F. O'Shaunnessy
Publikováno v:
British Journal of Haematology. 88:281-285
Summary. We report two cases of aplastic anaemia following exposure to ‘Ecstasy’ (MDMA, 3,4-methylenedioxymethamphetamine). In both cases the aplastic anaemia resolved spontaneously 7–9 weeks after presentation. Long-term bone marrow culture st
Autor:
T. R. Rutherford, John Scopes, Edward C. Gordon-Smith, Christopher Pocock, Gwen S. Draycott, S. Rizzo, Theodora Foukaneli, Frances M. Gibson
Publikováno v:
Experimental hematology. 32(7)
Objective Bone marrow from aplastic anemia (AA) patients shows reduced numbers in long-term culture (LTC)-initiating cell (LTC-IC) assays. The LTC-IC assay is based on assumptions of the culture kinetics of normal hematopoietic stem cells (HSC), whic
Autor:
John Scopes, Edward C. Gordon-Smith, Robin J. Shattock, Peter Hayes, Vikki Gill, Frances M. Gibson, George E. Griffin, Andrew R. Freedman
Publikováno v:
The Journal of infectious diseases. 176(6)
Hematologic abnormalities are often seen in patients infected with human immunodeficiency virus (HIV). The effect of HIV infection of bone marrow stroma on support of uninfected CD34 progenitor cells in long-term bone marrow culture (LTBMC) was inves
Autor:
John Scopes, Colin P. McGockin, Edward C. Gordon-Smith, Frances M. Gibson, S. Daly, Sarah E. Ball
Publikováno v:
British journal of haematology. 91(3)
We investigated the effect of the human ligand for flt-3 (FL) on the committed progenitor colony formation of normal bone marrow (BM) (n = 9) and BM from four aplastic anaemia (AA) and three Diamond-Blackfan anaemia (DBA) patients. Methylcellulose co