Zobrazeno 1 - 10
of 114
pro vyhledávání: '"John Scholler"'
Autor:
Abdulla Berjis, Deeksha Muthumani, Oscar A. Aguilar, Oz Pomp, Omar Johnson, Amanda V. Finck, Nils W. Engel, Linhui Chen, Nicolas Plachta, John Scholler, Lewis L. Lanier, Carl H. June, Neil C. Sheppard
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-13 (2024)
Abstract Human natural killer (NK) cell-based therapies are under assessment for treating various cancers, but cryopreservation reduces both the recovery and function of NK cells, thereby limiting their therapeutic feasibility. Using cryopreservation
Externí odkaz:
https://doaj.org/article/3fd910c3f98f4e43883f2a9ab9531d8c
Autor:
David Mai, Tifara Boyce, Aakash Mehta, Jordan Reff, John Scholler, Neil C. Sheppard, Carl H. June
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-10 (2024)
Abstract Loss of inflammatory effector function, such as cytokine production and proliferation, is a fundamental driver of failure in T cell therapies against solid tumors. Here, we used CRISPR/Cas9 to genetically disrupt ZFP36, an RNA binding protei
Externí odkaz:
https://doaj.org/article/43e2928bff434cb489ee369a6bdcb722
Autor:
Zebin Xiao, Leslie Todd, Li Huang, Estela Noguera-Ortega, Zhen Lu, Lili Huang, Meghan Kopp, Yue Li, Nimisha Pattada, Wenqun Zhong, Wei Guo, John Scholler, Maria Liousia, Charles-Antoine Assenmacher, Carl H. June, Steven M. Albelda, Ellen Puré
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-21 (2023)
Abstract The desmoplastic stroma in solid tumors presents a formidable challenge to immunotherapies that rely on endogenous or adoptively transferred T cells, however, the mechanisms are poorly understood. To define mechanisms involved, here we treat
Externí odkaz:
https://doaj.org/article/8293ae22274440439fe76629503609b5
Autor:
Carl H June, John Scholler, Joseph A Fraietta, Andrew Rech, Daniel Martinez, David Mai, Omar Johnson, Khatuna Gabunia, Regina M Young, Charles-Antoine Assenmacher, Enrico Radaelli, Giulia Golinelli, Ting-Jia Fan, Jordan Reff, Zachary Ferraro, Decheng Song, Aasha Gupta, Mansi Deshmukh, He N Xu, Wesley V Wilson, Julia C Tchou, Bruce L Levine
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 11, Iss Suppl 1 (2023)
Externí odkaz:
https://doaj.org/article/83b0afd714cd497b9913acbaca399ca6
Autor:
John Scholler, Jeffrey S. Otis
Publikováno v:
Journal of Clinical and Translational Science, Vol 7 (2023)
The obesity epidemic has continued to rise at an alarming rate and has increased health complications in children, adolescents, and adults. Resistance training, aerobic training, and a combination of the two have been shown to be effective at reducin
Externí odkaz:
https://doaj.org/article/c0e59e5fc8a44397bbf7d2cdf902350f
Autor:
Adham S. Bear, Tatiana Blanchard, Joseph Cesare, Michael J. Ford, Lee P. Richman, Chong Xu, Miren L. Baroja, Sarah McCuaig, Christina Costeas, Khatuna Gabunia, John Scholler, Avery D. Posey, Mark H. O’Hara, Anze Smole, Daniel J. Powell, Benjamin A. Garcia, Robert H. Vonderheide, Gerald P. Linette, Beatriz M. Carreno
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-16 (2021)
KRAS is commonly mutated at codon 12 in several cancer types, offering a unique opportunity for the development of neoantigen-targeted immunotherapy. Here the authors present a pipeline for the prediction, identification and validation of HLA class-I
Externí odkaz:
https://doaj.org/article/5c32458bd77b40989a4cd89c57021223
Autor:
Archana Thakur, John Scholler, Ewa Kubicka, Edwin T. Bliemeister, Dana L. Schalk, Carl H. June, Lawrence G. Lum
Publikováno v:
Frontiers in Immunology, Vol 12 (2021)
Adoptive T cell therapies for solid tumors is challenging. We generated metabolically enhanced co-activated-T cells by transducing intracellular co-stimulatory (41BB, ICOS or ICOS-27) and CD3ζ T cell receptor signaling domains followed by arming wit
Externí odkaz:
https://doaj.org/article/44fc3950d1424b9fb6857b674cd72b67
Autor:
Biliang Hu, Jiangtao Ren, Yanping Luo, Brian Keith, Regina M. Young, John Scholler, Yangbing Zhao, Carl H. June
Publikováno v:
Cell Reports, Vol 20, Iss 13, Pp 3025-3033 (2017)
The effects of transgenically encoded human and mouse IL-18 on T cell proliferation and its application in boosting chimeric antigen receptor (CAR) T cells are presented. Robust enhancement of proliferation of IL-18-secreting human T cells occurred i
Externí odkaz:
https://doaj.org/article/752ee465a8f44ba2800654c883ebc4e5
Autor:
Mireia Uribe-Herranz, Silvia Beghi, Marco Ruella, Kalpana Parvathaneni, Silvano Salaris, Nektarios Kostopoulos, Subin S. George, Stefano Pierini, Elisavet Krimitza, Francesca Costabile, Guido Ghilardi, Kimberly V. Amelsberg, Yong Gu Lee, Raymone Pajarillo, Caroline Markmann, Bevin McGettigan-Croce, Divyansh Agarwal, Noelle Frey, Simon F. Lacey, John Scholler, Khatuna Gabunia, Gary Wu, Elise Chong, David L. Porter, Carl H. June, Stephen J. Schuster, Vijay Bhoj, Andrea Facciabene
Publikováno v:
Molecular Therapy. 31:686-700
Autor:
Keisuke Watanabe, M. Angela Aznar, Shunichiro Kuramitsu, Mikko Siurala, Tong Da, Sangya Agarwal, Decheng Song, John Scholler, Antonia Rotolo, Avery D Posey, Alain H Rook, Paul L. Haun, Marco Ruella, Regina M. Young, Carl H June
Publikováno v:
Blood Advances.
A challenge when targeting T cell lymphoma with chimeric antigen receptor (CAR) T cell therapy is that target antigens are often shared between T cells and tumor cells, resulting in fratricide between CAR T cells and on-target cytotoxicity on normal