Zobrazeno 1 - 10
of 10
pro vyhledávání: '"John Saber"'
Autor:
Marie-Claude Sincennes, Caroline E. Brun, Alexander Y. T. Lin, Tabitha Rosembert, David Datzkiw, John Saber, Hong Ming, Yoh-ichi Kawabe, Michael A. Rudnicki
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-15 (2021)
The acetyltransferase MYST1 stimulated by acetyl-CoA, and the deacetylase SIRT2 stimulated by NAD+, regulate PAX7 acetylation in muscle stem cells, which in turn, regulates stem cell self-renewal and regeneration following injury in mouse skeletal mu
Externí odkaz:
https://doaj.org/article/24a0e0653321457e90cacbe83a5277e7
Autor:
Gregory C. Addicks, Caroline E. Brun, Marie-Claude Sincennes, John Saber, Christopher J. Porter, A. Francis Stewart, Patricia Ernst, Michael A. Rudnicki
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-14 (2019)
PAX7 transcription factor specifies the myogenic identity of muscle stem cells and acts as a nodal factor by stimulating proliferation while inhibiting differentiation. Here authors find that Mll1 deletion in myoblasts in mice results in reduced H3K4
Externí odkaz:
https://doaj.org/article/8f1a223e30424b10ab115c2947e3f185
Publikováno v:
F1000Research, Vol 9 (2020)
Satellite cells are the main muscle-resident cells responsible for muscle regeneration. Much research has described this population as being heterogeneous, but little is known about the different roles each subpopulation plays. Recent advances in the
Externí odkaz:
https://doaj.org/article/3d8bf330750a4c5c90955f77950b01a2
Autor:
Courtney Dowell-Esquivel, Peter Kallestrup, Sara Czaja, Colin A. Depp, John Saber, Philip D. Harvey
Publikováno v:
Biological Psychiatry. 93:S143
Autor:
John Saber, Michael A Rudnicki
Publikováno v:
Stem cells translational medicine. 11(11)
Coactivator-associated arginine methyltransferase 1 (CARM1) is a methyltransferase whose function has been highly studied in the context of nuclear receptor signaling. However, CARM1 is known to epigenetically regulate expression of several myogenic
Autor:
David Datzkiw, Yoh-ichi Kawabe, Alexander Y.T. Lin, Michael A. Rudnicki, John Saber, Tabitha Rosembert, Marie-Claude Sincennes, Hong Ming, Caroline E. Brun
Publikováno v:
Nature Communications
Nature Communications, Vol 12, Iss 1, Pp 1-15 (2021)
Nature Communications, Vol 12, Iss 1, Pp 1-15 (2021)
Muscle stem cell function has been suggested to be regulated by Acetyl-CoA and NAD+ availability, but the mechanisms remain unclear. Here we report the identification of two acetylation sites on PAX7 that positively regulate its transcriptional activ
Autor:
Michael A. Rudnicki, Caroline E. Brun, Christopher J. Porter, Marie-Claude Sincennes, A. Francis Stewart, John Saber, Patricia Ernst, Gregory C. Addicks
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-14 (2019)
Nature Communications
Nature Communications
PAX7 is a paired-homeobox transcription factor that specifies the myogenic identity of muscle stem cells and acts as a nodal factor by stimulating proliferation while inhibiting differentiation. We previously found that PAX7 recruits the H3K4 methylt
Autor:
Mary Anderson-Rowland, Armando Rodriguez, Richard Hall, Phil McBride, Rakesh Pangasa, John Saber, Clark Vangilder, Anita Grierson
Publikováno v:
2012 ASEE Annual Conference & Exposition Proceedings.
Autor:
Michael A. Rudnicki, Caroline E. Brun, Yoh-ichi Kawabe, Marie-Claude Sincennes, Tabitha Rosembert, John Saber
Publikováno v:
SSRN Electronic Journal.
The transcription factor PAX7 is a critical regulator of satellite cell survival, self-renewal and proliferation. PAX7 protein is regulated by different post-translational modifications that affect its transcriptional activity, and consequently, infl
Publikováno v:
F1000Research
Satellite cells are the main muscle-resident cells responsible for muscle regeneration. Much research has described this population as being heterogeneous, but little is known about the different roles each subpopulation plays. Recent advances in the