Zobrazeno 1 - 10
of 15
pro vyhledávání: '"John S. Zuzack"'
Autor:
Kathleen Storm, David B. Trollinger, Michael P. Bevilacqua, Min Zhan, Danute Bankaitis-Davis, John C. Cheronis, Victor Tryon, Dennis G. Macejak, John S. Zuzack
Publikováno v:
Drug Development Research. 63:8-21
Analysis of gene expression is emerging as a valuable tool in drug discovery. Using a gene expression system involving high-precision quantitative PCR, two robust in vitro models of inflammation in human whole blood were examined. In the first model,
Autor:
Michael Burkard, Val S. Goodfellow, Mary Francis, Manoj V. Marathe, Lajos Gera, Sherman E. Ross, Maciej Wieczorek, Timothy D. Fitzpatrick, Lyle W. Spruce, Steven W. Jones, Albert Gyorkos, John M. Stewart, Eric T. Whalley, John S. Zuzack, William M. Selig, Virginia E. Beckey, Anna Pilyavskaya
Publikováno v:
Biochemical Pharmacology. 54:283-291
The determination of the relationship between ligand affinity and bioactivity is important for the understanding of receptor function in biological systems and for drug development. Several physiological and pathophysiological functions of bradykinin
Autor:
D F Dyckes, M R Burkard, J K Blodgett, John S. Zuzack, Eric T. Whalley, H B Kroona, S E Ross, A H Leimer, D L Gernert
Publikováno v:
Canadian Journal of Physiology and Pharmacology. 75:633-638
Les maladies inflammatoires ont generalement une etiologie complexe et mettent en jeu une multitude de mediateurs; il semblerait donc approprie de les considerer en utilisant une approche polytherapeutique. Dans certaines conditions inflammatoires ch
Autor:
Mike Burkard, Wendy L. Hanson, Rosann G. McCullough, Lajos Gera, John M. Stewart, John S. Zuzack, Eric T. Whalley
Publikováno v:
Immunopharmacology. 33:51-60
Bradykinin B2 receptors are constitutively expressed, and require the entire peptide chain of bradykinin for recognition. Expression of B1 receptors is induced in inflammation; they recognize BK-(1–8). Heretofore blockade of all the actions of brad
Autor:
John M. Stewart, Wendy L. Hanson, Daniel C. Chan, Lajos Gera, Eric T. Whalley, John S. Zuzack
Publikováno v:
Immunopharmacology. 36(2-3)
Actions of bradykinin (Arg-Pro-Pro-Gly-Phe-Ser-Pro-Phe-Arg; BK) are mediated by constitutively expressed B2 receptors, that require the full BK peptide chain, and by B1 receptors, induced in inflammation, that use BK(1-8) as ligand. In addition to ma
Publikováno v:
Immunopharmacology. 33(1-3)
Autor:
Eric T. Whalley, Ved P. Srivastava, Virginia E. Beckey, Val S. Goodfellow, Steve Jones, Mary Francis, John S. Zuzack
Publikováno v:
Immunopharmacology. 33(1-3)
Publikováno v:
Immunopharmacology. 33(1-3)
Autor:
Robert A. Greer, David K. Cuadrado, Eric T. Whalley, William M. Selig, John S. Zuzack, Michael Burkard
Publikováno v:
Immunopharmacology. 33(1-3)
Autor:
Steve Jones, Lajos Gera, Eric T. Whalley, John S. Zuzack, Mary Francis, John Stewart, Michael Burkard
Publikováno v:
Immunopharmacology. 33(1-3)
We have undertaken a comparative pharmacological profile of novel bradykinin antagonists on human B1 and B2 receptor binding and functional assays. We found that there was an excellent correlation between binding and functional data for the compounds