Zobrazeno 1 - 10
of 87
pro vyhledávání: '"John S. Yeomans"'
Publikováno v:
PLoS ONE, Vol 6, Iss 11, p e27538 (2011)
Opiates, like other addictive drugs, elevate forebrain dopamine levels and are thought to do so mainly by inhibiting GABA neurons near the ventral tegmental area (VTA), in turn leading to a disinhibition of dopamine neurons. However, cholinergic inpu
Externí odkaz:
https://doaj.org/article/da92a77ce4874294893f4a43e8ba1cdf
Publikováno v:
Neuroscience & Biobehavioral Reviews. 83:72-82
Opioids, such as morphine or heroin, increase forebrain dopamine (DA) release and locomotion, and support the acquisition of conditioned place preference (CPP) or self-administration. The most sensitive sites for these opioid effects in rodents are i
Publikováno v:
Behavioural Brain Research. 252:176-179
Lesions of the pedunculopontine tegmental nucleus (PPT), one of two sources of cholinergic input to the ventral tegmental area (VTA), block conditioned place preference (CPP) for morphine in drug-naïve rats. M5 muscarinic cholinergic receptors, expr
Publikováno v:
European Journal of Neuroscience. 38:2774-2785
M5 muscarinic acetylcholine receptors expressed on ventral tegmental dopamine (DA) neurons are needed for opioid activation of DA outputs. Here, the M5 receptor gene was bilaterally transfected into neurons in the ventral tegmental area (VTA) or the
Publikováno v:
Genes, Brain and Behavior. 12:397-404
Dopamine signalling facilitates motivated behaviours, and the D2 dopamine receptor (D2R) is important in mother-infant interactions. D2R antagonists disrupt maternal behaviour and, in isolated rat pups, reduce ultrasonic vocalizations (USVs) that pro
Autor:
Nyresa C. Alves, Susanne Schmid, Robert J. Ure, Alexander R. Daros, John S. Yeomans, Daniel Bosch
Publikováno v:
European Journal of Neuroscience. 31:2053-2061
The acoustic startle reflex is strongly inhibited by a moderate-intensity acoustic stimulus that precedes the startling stimulus by roughly 10-1000 ms (prepulse inhibition, PPI). At long interstimulus intervals (ISIs) of 100-1000 ms, PPI in rats is r
Autor:
John S. Yeomans, Haoran Wang, Jing Wang, Frederic Wondisford, Ling He, Freda D. Miller, David L. Kaplan, Ian C. G. Weaver, Andrée Gauthier-Fisher
Publikováno v:
Developmental Cell. 18(1):114-125
SummaryIncreasing evidence indicates that epigenetic changes regulate cell genesis. Here, we ask about neural precursors, focusing on CREB binding protein (CBP), a histone acetyltransferase that, when haploinsufficient, causes Rubinstein-Taybi syndro
Publikováno v:
Brain Research. 1177:59-65
Nonphotic phase shifts of the circadian clock in mammals are mediated by the intergeniculate leaflet (IGL) of the thalamus via a geniculohypothalamic projection to the suprachiasmatic nucleus. These shifts can be induced by arousing stimuli, such as
Publikováno v:
European Journal of Neuroscience. 25:3359-3366
Circadian activity rhythms in mammals are controlled by the expression and transcriptional regulation of clock genes in the suprachiasmatic nucleus (SCN). The circadian cycle length in hamsters is regulated in part by casein kinase I epsilon (CKIepsi
Publikováno v:
The European journal of neuroscience. 44(1)
Opioids induce rewarding and locomotor effects by inhibiting rostromedial tegmental GABA neurons that express μ-opioid and nociceptin receptors. These GABA neurons then strongly inhibit dopamine neurons. Opioid-induced reward, locomotion and dopamin