Zobrazeno 1 - 10
of 102
pro vyhledávání: '"John S. Tsang"'
Autor:
Richard Apps, Angélique Biancotto, Julián Candia, Yuri Kotliarov, Shira Perl, Foo Cheung, Rohit Farmer, Matthew P. Mulè, Nicholas Rachmaninoff, Jinguo Chen, Andrew J. Martins, Rongye Shi, Huizhi Zhou, Neha Bansal, Paula Schum, Matthew J. Olnes, Pedro Milanez-Almeida, Kyu Lee Han, Brian Sellers, Mario Cortese, Thomas Hagan, Nadine Rouphael, Bali Pulendran, Lisa King, Jody Manischewitz, Surender Khurana, Hana Golding, Robbert G. van der Most, Howard B. Dickler, Ronald N. Germain, Pamela L. Schwartzberg, John S. Tsang
Publikováno v:
Cell Reports, Vol 43, Iss 9, Pp 114706- (2024)
Summary: To gain insight into how an adjuvant impacts vaccination responses, we use systems immunology to study human H5N1 influenza vaccination with or without the adjuvant AS03, longitudinally assessing 14 time points including multiple time points
Externí odkaz:
https://doaj.org/article/68501964c395404e9b87d185f2d87bdb
Autor:
Emily B. Warren, Eliza M. Gordon-Lipkin, Foo Cheung, Jinguo Chen, Amrita Mukherjee, Richard Apps, John S. Tsang, Jillian Jetmore, Melissa L. Schlein, Shannon Kruk, Yuanjiu Lei, A. Phillip West, Peter J. McGuire
Publikováno v:
Journal of Translational Medicine, Vol 21, Iss 1, Pp 1-14 (2023)
Abstract Background People with mitochondrial disease (MtD) are susceptible to metabolic decompensation and neurological symptom progression in response to an infection. Increasing evidence suggests that mitochondrial dysfunction may cause chronic in
Externí odkaz:
https://doaj.org/article/44675760c2e344a68fbf8c16a8ad5f5b
Autor:
Joann Diray-Arce, Helen E. R. Miller, Evan Henrich, Bram Gerritsen, Matthew P. Mulè, Slim Fourati, Jeremy Gygi, Thomas Hagan, Lewis Tomalin, Dmitry Rychkov, Dmitri Kazmin, Daniel G. Chawla, Hailong Meng, Patrick Dunn, John Campbell, The Human Immunology Project Consortium (HIPC), Minnie Sarwal, John S. Tsang, Ofer Levy, Bali Pulendran, Rafick Sekaly, Aris Floratos, Raphael Gottardo, Steven H. Kleinstein, Mayte Suárez-Fariñas
Publikováno v:
Scientific Data, Vol 9, Iss 1, Pp 1-16 (2022)
Measurement(s) Transcriptomics • Hemagglutination Inhibition Assay • IgG IgM IgA Total Measurement • Virus-neutralizing Antibody • ELISA Technology Type(s) Microarray • RNA sequencing • Hemagglutination Inhibition Assay • ELISA • Micr
Externí odkaz:
https://doaj.org/article/e29b684ada444c44833f7762240235b8
Autor:
Felipe Lopes de Assis, Kenneth B. Hoehn, Xiaozhen Zhang, Lela Kardava, Connor D. Smith, Omar El Merhebi, Clarisa M. Buckner, Krittin Trihemasava, Wei Wang, Catherine A. Seamon, Vicky Chen, Paul Schaughency, Foo Cheung, Andrew J. Martins, Chi-I Chiang, Yuxing Li, John S. Tsang, Tae-Wook Chun, Steven H. Kleinstein, Susan Moir
Publikováno v:
Cell Reports, Vol 42, Iss 7, Pp 112780- (2023)
Summary: Protective immunity following vaccination is sustained by long-lived antibody-secreting cells and resting memory B cells (MBCs). Responses to two-dose SARS-CoV-2 mRNA-1273 vaccination are evaluated longitudinally by multimodal single-cell an
Externí odkaz:
https://doaj.org/article/0741d21fc63c4181b8b82bf41955424e
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-12 (2022)
Current single cell protein expression profiling approaches come with substantial measurement noise. Here the authors discover the sources of this noise and develop a denoising algorithm that improves data quality and downstream applications.
Externí odkaz:
https://doaj.org/article/01e0db9ea26e48418ff9d13820efbeb6
Autor:
Candace C. Liu, Yongjian Guo, Kiera L. Vrindten, William W. Lau, Rachel Sparks, John S. Tsang
Publikováno v:
STAR Protocols, Vol 3, Iss 3, Pp 101474- (2022)
Summary: OMiCC (OMics Compendia Commons) is a biologist-friendly web platform that facilitates data reuse and integration. Users can search over 40,000 publicly available gene expression studies, annotate and curate samples, and perform meta-analysis
Externí odkaz:
https://doaj.org/article/47563f19d145416f8a8d6833805d9a33
Autor:
Michael S. Abers, Ottavia M. Delmonte, Emily E. Ricotta, Jonathan Fintzi, Danielle L. Fink, Adriana A. Almeida de Jesus, Kol A. Zarember, Sara Alehashemi, Vasileios Oikonomou, Jigar V. Desai, Scott W. Canna, Bita Shakoory, Kerry Dobbs, Luisa Imberti, Alessandra Sottini, Eugenia Quiros-Roldan, Francesco Castelli, Camillo Rossi, Duilio Brugnoni, Andrea Biondi, Laura Rachele Bettini, Mariella D’Angio’, Paolo Bonfanti, Riccardo Castagnoli, Daniela Montagna, Amelia Licari, Gian Luigi Marseglia, Emily F. Gliniewicz, Elana Shaw, Dana E. Kahle, Andre T. Rastegar, Michael Stack, Katherine Myint-Hpu, Susan L. Levinson, Mark J. DiNubile, Daniel W. Chertow, Peter D. Burbelo, Jeffrey I. Cohen, Katherine R. Calvo, John S. Tsang, NIAID COVID-19 Consortium, Helen C. Su, John I. Gallin, Douglas B. Kuhns, Raphaela Goldbach-Mansky, Michail S. Lionakis, Luigi D. Notarangelo
Publikováno v:
JCI Insight, Vol 6, Iss 1 (2021)
Immune and inflammatory responses to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) contribute to disease severity of coronavirus disease 2019 (COVID-19). However, the utility of specific immune-based biomarkers to predict clinical outc
Externí odkaz:
https://doaj.org/article/feaeec76ff49437f8d320c0de85e7c30
Publikováno v:
F1000Research, Vol 5 (2016)
Background: The proliferation of publicly accessible large-scale biological data together with increasing availability of bioinformatics tools have the potential to transform biomedical research. Here we report a crowdsourcing Jamboree that explored
Externí odkaz:
https://doaj.org/article/0bdb4f2b2f9847f9a1d9e1404c17d94d
Autor:
Julián Candia, John S Tsang
Publikováno v:
BMC Bioinformatics, Vol 20, Iss 1, Pp 1-11 (2019)
Abstract Background Regularized generalized linear models (GLMs) are popular regression methods in bioinformatics, particularly useful in scenarios with fewer observations than parameters/features or when many of the features are correlated. In both
Externí odkaz:
https://doaj.org/article/55c0b1f0bb1e4071ab454d748f8002fd
Pan-vaccine analysis reveals innate immune endotypes predictive of antibody responses to vaccination
Autor:
Slim, Fourati, Lewis E, Tomalin, Matthew P, Mulè, Daniel G, Chawla, Bram, Gerritsen, Dmitry, Rychkov, Evan, Henrich, Helen E R, Miller, Thomas, Hagan, Joann, Diray-Arce, Patrick, Dunn, Ofer, Levy, Raphael, Gottardo, Minnie M, Sarwal, John S, Tsang, Mayte, Suárez-Fariñas, Bali, Pulendran, Steven H, Kleinstein, Alkis, Togias
Publikováno v:
Nature Immunology. 23:1777-1787
Several studies have shown that the pre-vaccination immune state is associated with the antibody response to vaccination. However, the generalizability and mechanisms that underlie this association remain poorly defined. Here, we sought to identify a