Zobrazeno 1 - 10
of 89
pro vyhledávání: '"John S. Svendsen"'
Autor:
Melissa R. Stasko, John S. Svendsen, Ulli Rothweiler, Ilya Bederman, Wenche Stensen, Anders Fugelli, Richard A. Engh, Alberto C.S. Costa
Publikováno v:
Pharmaceuticals
Volume 14
Issue 11
Pharmaceuticals, Vol 14, Iss 1170, p 1170 (2021)
Volume 14
Issue 11
Pharmaceuticals, Vol 14, Iss 1170, p 1170 (2021)
Down syndrome (DS) is a complex genetic disorder associated with substantial physical, cognitive, and behavioral challenges. Due to better treatment options for the physical co-morbidities of DS, the life expectancy of individuals with DS is beginnin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0506dad4ff312168421347236e880f43
https://hdl.handle.net/10037/23536
https://hdl.handle.net/10037/23536
Autor:
Aman Dekebo, John S. Svendsen, Eva Brichtová, Sang Ho Lee, Zae Sung No, Young Sik Jung, Petr Bouř, Johan Isaksson, Worku Dinku, Sang Un Choi, Fredrik Garnås Rylandsholm, Arne Jørgen Aasen
Publikováno v:
Applied Biological Chemistry. 63
Myrrh, a resin derived from the damaged bark of Commiphora genus, has traditionally been used for treatment of various human diseases, such as amenorrhea, ache, tumors, fever, and stomach pains. In spite of this widespread use of the myrrh in Ethiopi
Publikováno v:
ACS Omega
ACS Omega, Vol 5, Iss 10, Pp 4937-4942 (2020)
ACS Omega, Vol 5, Iss 10, Pp 4937-4942 (2020)
Short histidine-rich peptides could serve as novel activatable vectors for delivering cytotoxic payloads to tumor and neovasculature cells. This explorative study reports preliminary results showing that zinc ions, which are found in elevated levels
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5debd3af65e50c5cf690f17ed2c6dc6e
https://hdl.handle.net/11250/2673153
https://hdl.handle.net/11250/2673153
Publikováno v:
The Journal of Physical Chemistry A. 121:6830-6837
Cis/trans isomerization of 2°-amide bonds is a key step in a wide range of important processes. Here we present a theoretical assessment of cis/trans isomerization of 2°-amide bonds using B3LYP density functional methods, describing two reaction pa
Autor:
Dominik Ausbacher, Trine Stiberg, J. Johannes Eksteen, John S. Svendsen, Imin Wushur, Cristiane de A. Cavalcanti-Jacobsen, Jaione Simon-Santamaria, Øystein Rekdal
Publikováno v:
Journal of Medicinal Chemistry. 60:146-156
Oncolytic peptides represent a promising new strategy within the field of cancer immunotherapy. Here we describe the systematic design and evaluation of short antilymphoma peptides within this paradigm. The peptides were tested in vitro and in vivo t
Publikováno v:
Accounts of chemical research. 52(3)
The alarming rate at which micro-organisms are developing resistance to conventional antibiotics represents one of the global challenges of our time. There is currently ample space in the antibacterial drug pipeline, and scientists are trying to find
Autor:
Frederick Alan Leeson, John S. Svendsen, Richard A. Engh, Johan Isaksson, Ulli Rothweiler, Bjørn Olav Brandsdal, Wenche Stensen
Publikováno v:
Journal of Medicinal Chemistry. 59:9814-9824
DYRK1A has emerged as a potential target for therapies of Alzheimer's disease using small molecules. On the basis of the observation of selective DYRK1A inhibition by firefly d-luciferin, we have explored static and dynamic structural properties of f
Autor:
Guillaume Serin, Bjarte Mortensen, John S. Svendsen, Øystein Rekdal, Ketil André Camilio, Liv Tone Eliassen, Kristel Berg, Bengt Erik Haug, Jean-Francois Mirjolet, Wenche Stensen, Francis Bichat
Publikováno v:
Journal of Medicinal Chemistry. 59:2918-2927
Oncolytic immunotherapies represent a new promising strategy in the treatment of cancer. In our efforts to develop oncolytic peptides, we identified a series of chemically modified 9-mer cationic peptides that were highly effective against both drug-
Publikováno v:
Molecules
Volume 23
Issue 10
Molecules, Vol 23, Iss 10, p 2455 (2018)
Molecules : A Journal of Synthetic Chemistry and Natural Product Chemistry
Volume 23
Issue 10
Molecules, Vol 23, Iss 10, p 2455 (2018)
Molecules : A Journal of Synthetic Chemistry and Natural Product Chemistry
Source at https://doi.org/10.3390/molecules23102455 . Cis/trans isomerization of amide bonds is a key step in a wide range of biological and synthetic processes. Occurring through C-N amide bond rotation, it also coincides with the activation of amid
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4b74d47a07786c3877c904de8546a215
https://hdl.handle.net/10037/13895
https://hdl.handle.net/10037/13895
Autor:
Wenche Stensen, Richard A. Engh, Jonas Eriksson, John S. Svendsen, Frederick Alan Leeson, Ulli Rothweiler
Publikováno v:
European Journal of Medicinal Chemistry. 94:140-148
D-Luciferin is widely used as a substrate in luciferase catalysed bioluminescence assays for in vitro studies. However, little is known about cross reactivity and potential interference of D-luciferin with other enzymes. We serendipitously found that