Výsledky vyhledávání - "John S. Rudge"

Angiopoietins bind thrombomodulin and inhibit its function as a thrombin cofactor

Autor: George D. Yancopoulos, Elizabeth Pasnikowski, Carla Castanaro, Nicholas J. Papadopoulos, Benjamin R. Thomson, Xiabo Jiang, Susan E. Quaggin, Gavin Thurston, Samuel Davis, Christopher Daly, John S. Rudge, Xiaozhong Qian, Yang Wei

Publikováno v: Scientific Reports
Scientific Reports, Vol 8, Iss 1, Pp 1-12 (2018)

Angiopoietin-1 (Ang1) and Angiopoietin-2 (Ang2) are ligands for Tie2, an endothelial-specific receptor tyrosine kinase that is an essential regulator of angiogenesis. Here we report the identification, via expression cloning, of thrombomodulin (TM) a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7331aac57976084058c294645598c410
http://europepmc.org/articles/PMC5765006

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Antibody drug conjugates of cleavable amino-alkyl and aryl maytansinoids

Publikováno v: Bioorganicmedicinal chemistry. 26(9)

Natural products have been used for many medicinal purposes for centuries. Antibody drug conjugates (ADCs) have utilized this rich source of small molecule therapeutics to produce several clinically useful treatments. ADCs based on the natural produc

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dbd038dc1328967ccf7495a2b9161a1d
https://pubmed.ncbi.nlm.nih.gov/29605304

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ERBB3/HER2 Signaling Promotes Resistance to EGFR Blockade in Head and Neck and Colorectal Cancer Models

Autor: Jeanette L. Fairhurst, Christopher Daly, Katie Yang, Gang Chen, Liangfen Fan, Ergang Shi, Carla Castanaro, Joel H. Martin, Ashique Rafique, Douglas MacDonald, Gavin Thurston, Tammy T. Huang, Jing Shan, Bo Luan, John S. Rudge, Li Zhang, Frank Delfino, Terra Potocky

Publikováno v: Molecular Cancer Therapeutics. 13:1345-1355

EGFR blocking antibodies are approved for the treatment of colorectal cancer and head and neck squamous cell carcinoma (HNSCC). Although ERBB3 signaling has been proposed to limit the effectiveness of EGFR inhibitors, the underlying molecular mechani

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a18553166d863f482a80fbe0490ae920
https://doi.org/10.1158/1535-7163.mct-13-1033

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Inhibition of Delta-Like Ligand 4 Induces Luteal Hypervascularization Followed by Functional and Structural Luteolysis in the Primate Ovary

Autor: Hamish M. Fraser, John S. Rudge, Julie M. Hastings, Deborah Allan, Keith Morris, Stanley J. Wiegand

Publikováno v: Fraser, H M, Hastings, J M, Allan, D, Morris, K D, Rudge, J S & Wiegand, S J 2012, ' Inhibition of delta-like ligand 4 induces luteal hypervascularization followed by functional and structural luteolysis in the primate ovary ', Endocrinology, vol. 153, no. 4, pp. 1972-83 . https://doi.org/10.1210/en.2011-1688
Endocrinology

Using specific inhibitors established that angiogenesis in the ovarian follicle and corpus luteum is driven by vascular endothelial growth factor. Recently, it has been demonstrated that the Notch ligand, delta-like ligand 4 (Dll4) negatively regulat

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ef2682162fdb3ec6f2d4c9a4f76e6d7a
https://doi.org/10.1210/en.2011-1688

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Hyperalgesia, synovitis and multiple biomarkers of inflammation are suppressed by interleukin 1 inhibition in a novel animal model of gouty arthritis

Autor: George D. Yancopoulos, Macdonald Lynn, Robert Terkeltaub, Andrew J. Murphy, Ru Liu-Bryan, Richard Torres, John S. Rudge, Donna Hylton, Joel C. Reinhardt, Sean Stevens, Susan D. Croll, Dore Anthony T

Publikováno v: Annals of the Rheumatic Diseases. 68:1602-1608

Background: Monosodium urate (MSU) and calcium pyrophosphate dihydrate (CPPD) crystal-induced interleukin 1 β (IL1β) release contributes to inflammation in subcutaneous air pouch and peritoneal models of acute gout and pseudogout. However, conseque

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::9f7d6d3f83dcfef58b7525f9edbbdb15
https://doi.org/10.1136/ard.2009.109355

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Angiopoietin-1 therapy enhances fibrosis and inflammation following folic acid-induced acute renal injury

Autor: Karen L. Price, Adrian S. Woolf, Claire M. Gannon, George D. Yancopoulos, John S. Rudge, David A. Long, Luigi Gnudi, Ella Ioffe, Kathryn White

Publikováno v: Kidney International. 74:300-309

The loss of interstitial capillaries is a feature of several experimental models of renal disease and this contributes to secondary kidney injury. Angiopoietin-1 is a secreted growth factor which binds to Tie-2 present on endothelia to enhance cell s

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8b28035ab4dc924369e3d0eed96b3013
https://doi.org/10.1038/ki.2008.179

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Vascular endothelial growth factor is up-regulated after status epilepticus and protects against seizure-induced neuronal loss in hippocampus

Autor: Jamee N. Nicoletti, Ashraf S. Elkady, Helen E. Scharfman, Jeffrey H. Goodman, Donna Hylton, Susan D. Croll, Daniel P. McCloskey, H. Atassi, S.K. Shah, John S. Rudge

Publikováno v: Neuroscience. 151:232-241

Vascular endothelial growth factor (VEGF) is a protein factor which has been found to play a significant role in both normal and pathological states. Its role as an angiogenic factor is well-established. More recently, VEGF has been shown to protect

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::bfb6a9d2e5519453f76cda956a1f614d
https://doi.org/10.1016/j.neuroscience.2007.09.083

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