Zobrazeno 1 - 10
of 47
pro vyhledávání: '"John S. Mudgett"'
Autor:
Teja Celhar, Hao Kim Lu, Lia Benso, Larissa Rakhilina, Hui Yin Lee, Shubhita Tripathi, Olga Zharkova, Wei Yee Ong, Hiroko Yasuga, Bijin Au, Damien Marlier, Lina Hsiu Kim Lim, Thomas Paulraj Thamboo, John S. Mudgett, Matthew F. Mackey, Dennis M. Zaller, John E. Connolly, Anna-Marie Fairhurst
Publikováno v:
Frontiers in Immunology, Vol 10 (2019)
The global increase in autoimmunity, together with the emerging autoimmune-related side effects of cancer immunotherapy, have furthered a need for understanding of immune tolerance and activation. Systemic lupus erythematosus (SLE) is the archetypica
Externí odkaz:
https://doaj.org/article/63e6049e459c4c149afe2835da0980ef
Autor:
Mali Liu, Guoxin Wu, Jennifer Baysarowich, Michael Kavana, George H. Addona, Kathleen K. Bierilo, John S. Mudgett, Guillaume Pavlovic, Ayesha Sitlani, John J. Renger, Brian K. Hubbard, Timothy S. Fisher, Celina V. Zerbinatti
Publikováno v:
Journal of Lipid Research, Vol 51, Iss 9, Pp 2611-2618 (2010)
Proprotein convertase subtilisin/kexin type 9 (PCSK9) is a secreted protein that regulates hepatic low-density lipoprotein receptor (LDLR) levels in humans. PCSK9 has also been shown to regulate the levels of additional membrane-bound proteins in vit
Externí odkaz:
https://doaj.org/article/4c28810f0e7f4bedb9bdad0182e74028
Autor:
Laura Engstrom, Kyle J. Piers, Kenneth Jay Barr, Renu Jain, Dallas C. Jones, Huseyin Mehmet, Heidi Ferguson, Gary D. Glick, John S. Mudgett, Richard Miller, Xiao Hu, Hongjun Zhang, I-Ming Wang, Abbas Hawwari, Craig C. Correll, Barbara Joyce-Shaikh, Razvan Cristescu, Yanxia Guo, Daniel J. Cua, Gretchen A. Baltus, Yi Chen, Thomas Daniel Aicher, Dennis M. Zaller, Laura L. Carter, Laxminarayan G Hegde, Kenzie D. MacIsaac
Publikováno v:
Cell Reports, Vol 17, Iss 12, Pp 3206-3218 (2016)
Recent studies have elucidated the molecular mechanism of RORγT transcriptional regulation of Th17 differentiation and function. RORγT was initially identified as a transcription factor required for thymopoiesis by maintaining survival of CD4+CD8+
Autor:
Hugues Jacob, Lola Madeira, Yann Herault, Guillaume Pavlovic, Marie-France Champy, Laurent Monassier, Lahcen El Fertak, Marie-Christine Birling, Ghina Bou-About, Tania Sorg, John S. Mudgett, Benoit Petit-Demoulière, Estelle Ayme-Dietrich
Publikováno v:
Archives of cardiovascular diseases
Archives of cardiovascular diseases, 2017, 111 (1), pp.41-52. ⟨10.1016/j.acvd.2017.03.011⟩
Archives of cardiovascular diseases, 2017, 111 (1), pp.41-52. ⟨10.1016/j.acvd.2017.03.011⟩
Summary Background Metabolic syndrome is a combination of symptoms including obesity, dyslipidaemia, glucose intolerance and hypertension. Oxidative stress appears to be a pathophysiological factor that links these signs and encourages progression to
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::62c2eba755079d22dbf35b9bc9a78963
https://hal.science/hal-03671917
https://hal.science/hal-03671917
Autor:
Loic Lindner, Patrick T. Reilly, Marie-France Champy, Aline Dubos, Hervé Luche, Yann Herault, Isabelle Goncalves Da Cruz, Solène Jaubert, Hugues Jacobs, Tania Sorg, Marie Malissen, Manuel Mark, Thomas W. Rosahl, John S. Mudgett, Guillaume Pavlovic, Roy Combe, Olivia Wendling
Publikováno v:
Scientific Reports
Scientific Reports, 2017, 7 (1), ⟨10.1038/s41598-017-08845-7⟩
Scientific Reports, Vol 7, Iss 1, Pp 1-15 (2017)
Scientific Reports, 2017, 7 (1), ⟨10.1038/s41598-017-08845-7⟩
Scientific Reports, Vol 7, Iss 1, Pp 1-15 (2017)
ATP6AP2 codes for the (pro)renin receptor and is an essential component of vacuolar H+ ATPase. Activating (pro)renin for conversion of Angiotensinogen to Angiotensin makes ATP6AP2 attractive for drug intervention. Tissue-specific ATP6AP2 inactivation
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2f9a8192cf734b9643b1d2a65a488283
https://hal.science/hal-03676411
https://hal.science/hal-03676411
Autor:
Benoit Petit-Demoulière, Marie-France Champy, John S. Mudgett, Laurent Monassier, Li-Jun Ma, Hong-Ping Guan, Robert W. Myers, Yann Herault, Wen Feng, Cai Li, Hongwu Wang, Mark D. Erion, Hugues Jacobs, Ghina Bou-About, Roger Askew, Ku Lu, Xiaodong Yang, David E. Kelley, Guillaume Pavlovic, Tania Sorg
Publikováno v:
Journal of Biological Chemistry
Journal of Biological Chemistry, American Society for Biochemistry and Molecular Biology, 2016, 291 (45), pp.23428-23439. ⟨10.1074/jbc.M116.738591⟩
Journal of Biological Chemistry, American Society for Biochemistry and Molecular Biology, 2016, 291 (45), pp.23428-23439. ⟨10.1074/jbc.M116.738591⟩
International audience; Mutations of the AMP-activated kinase gamma 2 subunit (AMPKγ2), N488I (AMPKγ2NI) and R531G (AMPKγ2RG), are associated with Wolff-Parkinson-White (WPW) syndrome, a cardiac disorder characterized by ventricular pre-excitation
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2e39b213a1b950f90bf54fa3de5444eb
https://linkinghub.elsevier.com/retrieve/pii/S0021925820356234
https://linkinghub.elsevier.com/retrieve/pii/S0021925820356234
Autor:
Marie-France Champy, Laurent Monassier, Benoit Petit-Demoulière, Yann Herault, Lahcen El Fertak, Roy Combe, Estelle Ayme-Dietrich, John S. Mudgett, Jeffrey Madwed, Tania Sorg
Publikováno v:
PLoS ONE
PLoS ONE, Public Library of Science, 2016, 11 (4), pp.e0153472. ⟨10.1371/journal.pone.0153472⟩
PLoS ONE, Vol 11, Iss 4, p e0153472 (2016)
PLoS ONE, Public Library of Science, 2016, 11 (4), pp.e0153472. ⟨10.1371/journal.pone.0153472⟩
PLoS ONE, Vol 11, Iss 4, p e0153472 (2016)
International audience; Background: Mouse transgenesis has provided the unique opportunity to investigate mechanisms underlying sodium kidney reabsorption as well as end organ damage. However, understanding mouse background and the experimental condi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f8ab6b47e1e051db7c50f43b6fd1c314
https://hal.archives-ouvertes.fr/hal-03445368
https://hal.archives-ouvertes.fr/hal-03445368
Autor:
John S. Mudgett, Richard M. Ransohoff, J. Menetski, Julie A. DeMartino, Catherine Abbadie, D.E. MacIntyre, Shruti Mistry, Min Lu
Publikováno v:
Neuroscience. 149:706-714
Recent findings demonstrate that chemokines, and more specifically CC chemokine ligand 2 (CCL2 or monocyte chemoattractant protein-1), play a major role in pain processing. In the present study, we assess nociceptive responses of mice that overexpres
Autor:
Susan Cupo, John S. Mudgett, Nicole A. Chartrain, Karen Lowitz, Catherine E. Fitzgerald, Dennis M. Zaller, Ester Carballo-Jane, Stephen J. O'Keefe, Silvi Luell, Cordelia Rasa, Karen Owens, Shiow-Ling Chen, Denise M. Visco, Janey N. Parsons
Publikováno v:
Journal of Biological Chemistry. 282:34663-34671
The p38 MAP kinase signal transduction pathway is an important regulator of proinflammatory cytokine production and inflammation. Defining the roles of the various p38 family members, specifically p38alpha and p38beta, in these processes has been dif
Autor:
Howard Y. Chen, Marc L. Reitman, Hongyue Dai, Sheena Mumick, John S. Mudgett, Airu Chen, John Lamb, Su Qian, Drew T. Weingarth, Chunsheng Zhang, Douglas J. MacNeil
Publikováno v:
Obesity Research. 13:1311-1320
Objective: To examine the effect of a high-fat diet on gene expression in adipose tissues and to determine induction kinetics of adipose monocyte chemoattractant protein-1 and −3 (MCP-1 and MCP-3) in diet-induced obesity (DIO) and the effect of a l