Zobrazeno 1 - 10
of 270
pro vyhledávání: '"John S. Millar"'
Autor:
Hubert Monnerie, Micah Romer, Lindsay M. Roth, Caela Long, John S. Millar, Kelly L. Jordan-Sciutto, Judith B. Grinspan
Publikováno v:
Frontiers in Molecular Neuroscience, Vol 16 (2023)
Combined antiretroviral therapy (cART) has greatly decreased mortality and morbidity among persons with HIV; however, neurologic impairments remain prevalent, in particular HIV-associated neurocognitive disorders (HANDs). White matter damage persists
Externí odkaz:
https://doaj.org/article/d47bdc2e2ecf4e7fa6028db6e43612a6
Autor:
Yi Hu, Jon G. Sanders, Piotr Łukasik, Catherine L. D’Amelio, John S. Millar, David R. Vann, Yemin Lan, Justin A. Newton, Mark Schotanus, Daniel J. C. Kronauer, Naomi E. Pierce, Corrie S. Moreau, John T. Wertz, Philipp Engel, Jacob A. Russell
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-14 (2018)
Gut bacteria are prevalent across insects including ants, but their precise roles are often unclear. Here, Hu et al. show that microbes aid ants by recycling nitrogen into bio-available amino acids. This function is conserved across the turtle ants,
Externí odkaz:
https://doaj.org/article/d9b391e19cbc4dceb4b083246b646635
Autor:
William Hancock-Cerutti, John S. Millar, Silvia Valentini, Jason Liu, Jeffrey T. Billheimer, Daniel J. Rader, Marina Cuchel
Publikováno v:
Molecules, Vol 26, Iss 22, p 6862 (2021)
High-density lipoprotein cholesterol (HDL-C) is thought to be atheroprotective yet some patients with elevated HDL-C levels develop cardiovascular disease, possibly due to the presence of dysfunctional HDL. We aimed to assess the metabolic fate of ci
Externí odkaz:
https://doaj.org/article/f66898c6d66140b4838705aadba64154
Autor:
John S. Millar, Michael E. Lassman, Tiffany Thomas, Rajasekhar Ramakrishnan, Patricia Jumes, Richard L. Dunbar, Emil M. deGoma, Amanda L. Baer, Wahida Karmally, Daniel S. Donovan, Hashmi Rafeek, John A. Wagner, Stephen Holleran, Joseph Obunike, Yang Liu, Soumia Aoujil, Taylor Standiford, David E. Gutstein, Henry N. Ginsberg, Daniel J. Rader, Gissette Reyes-Soffer
Publikováno v:
Journal of Lipid Research, Vol 58, Iss 6, Pp 1214-1220 (2017)
Cholesteryl ester transfer protein (CETP) mediates the transfer of HDL cholesteryl esters for triglyceride (TG) in VLDL/LDL. CETP inhibition, with anacetrapib, increases HDL-cholesterol, reduces LDL-cholesterol, and lowers TG levels. This study descr
Externí odkaz:
https://doaj.org/article/519f42374d614106b1158dd25fc71604
Autor:
Ying Liu, Donna M. Conlon, Xin Bi, Katherine J. Slovik, Jianting Shi, Hailey I. Edelstein, John S. Millar, Ali Javaheri, Marina Cuchel, Evanthia E. Pashos, Jahangir Iqbal, M. Mahmood Hussain, Robert A. Hegele, Wenli Yang, Stephen A. Duncan, Daniel J. Rader, Edward E. Morrisey
Publikováno v:
Cell Reports, Vol 19, Iss 7, Pp 1456-1466 (2017)
Abetalipoproteinemia (ABL) is an inherited disorder of lipoprotein metabolism resulting from mutations in microsomal triglyceride transfer protein (MTTP). In addition to expression in the liver and intestine, MTTP is expressed in cardiomyocytes, and
Externí odkaz:
https://doaj.org/article/d7125650f9fd4644a056f52767d91fcf
Autor:
Takashi Kuwano, Xin Bi, Eleonora Cipollari, Tomoyuki Yasuda, William R. Lagor, Hannah J. Szapary, Junichiro Tohyama, John S. Millar, Jeffrey T. Billheimer, Nicholas N. Lyssenko, Daniel J. Rader
Publikováno v:
Journal of Lipid Research, Vol 58, Iss 4, Pp 731-741 (2017)
Phospholipid transfer protein (PLTP) may affect macrophage reverse cholesterol transport (mRCT) through its role in the metabolism of HDL. Ex vivo cholesterol efflux capacity and in vivo mRCT were assessed in PLTP deletion and PLTP overexpression mic
Externí odkaz:
https://doaj.org/article/30e2e9d4b91542ebb5a875850544e06c
Autor:
Marina Cuchel, Anna C. Raper, Donna M. Conlon, Daniel A. Pryma, Richard H. Freifelder, Rahul Poria, Debra Cromley, Xiaoyu Li, Richard L. Dunbar, Benjamin French, Liming Qu, William Farver, Ching-Chiang Su, Sissel Lund-Katz, Amanda Baer, Giacomo Ruotolo, Peter Akerblad, Carol S. Ryan, Lan Xiao, Todd G. Kirchgessner, John S. Millar, Jeffrey T. Billheimer, Daniel J. Rader
Publikováno v:
Journal of Lipid Research, Vol 58, Iss 4, Pp 752-762 (2017)
Reverse cholesterol transport (RCT) is thought to be an atheroprotective function of HDL, and macrophage-specific RCT in mice is inversely associated with atherosclerosis. We developed a novel method using 3H-cholesterol nanoparticles to selectively
Externí odkaz:
https://doaj.org/article/50852041bbb149b0ab71cadc9ddee278
Autor:
Andrea J. Luthi, Nicholas N. Lyssenko, Duyen Quach, Kaylin M. McMahon, John S. Millar, Kasey C. Vickers, Daniel J. Rader, Michael C. Phillips, Chad A. Mirkin, C.Shad Thaxton
Publikováno v:
Journal of Lipid Research, Vol 56, Iss 5, Pp 972-985 (2015)
The ability of HDL to support macrophage cholesterol efflux is an integral part of its atheroprotective action. Augmenting this ability, especially when HDL cholesterol efflux capacity from macrophages is poor, represents a promising therapeutic stra
Externí odkaz:
https://doaj.org/article/cbf0a92bb5874c11a69dc96e5efce1af
Autor:
Esther M.M. Ooi, Alice H. Lichtenstein, John S. Millar, Margaret R. Diffenderfer, Stefania Lamon-Fava, Helen Rasmussen, Francine K. Welty, P. Hugh R. Barrett, Ernst J. Schaefer
Publikováno v:
Journal of Lipid Research, Vol 53, Iss 9, Pp 1958-1967 (2012)
The effects of Therapeutic Lifestyle Change (TLC) diets, low and high in dietary fish, on apolipoprotein metabolism were examined. Subjects were provided with a Western diet for 6 weeks, followed by 24 weeks of either of two TLC diets (10/group). Apo
Externí odkaz:
https://doaj.org/article/05eddb736f9645378e65da50bead7e46
Autor:
Margaret R. Diffenderfer, Margaret E. Brousseau, John S. Millar, P.Hugh R. Barrett, Chorthip Nartsupha, Peter M. Schaefer, Megan L. Wolfe, Gregory G. Dolnikowski, Daniel J. Rader, Ernst J. Schaefer
Publikováno v:
Journal of Lipid Research, Vol 53, Iss 6, Pp 1190-1199 (2012)
Cholesteryl ester transfer protein (CETP) facilitates the transfer of HDL cholesteryl ester to triglyceride-rich lipoproteins (TRL). This study aimed to determine the effects of CETP inhibition with torcetrapib on TRL composition and apoB-48 metaboli
Externí odkaz:
https://doaj.org/article/fa9c3f7efd514b1fb91b9148d019c5da