Zobrazeno 1 - 10
of 194
pro vyhledávání: '"John S. Fleming"'
Autor:
John S. Fleming, Eva Bondesson, Christopher McCrae, Joy Conway, Matthew Guy, Mats Carlsson, Livia Tossici-Bolt, Michael J. Bennett, François-Xavier Blé
Publikováno v:
Journal of Aerosol Medicine and Pulmonary Drug Delivery. 33:342-356
Background: Mucociliary clearance (MCC) rate from the lung has been shown to be reduced in chronic obstructive pulmonary disease (COPD). This study investigates the value of regional clearance measurements in assessing MCC in mild-to-moderate disease
Autor:
Michael J. Bennett, John S. Fleming, Mats Carlsson, Joy Conway, Eva Bondesson, Christopher McCrae, François-Xavier Blé, Matthew Guy, Livia Tossici-Bolt
Publikováno v:
Journal of aerosol medicine and pulmonary drug delivery. 32(4)
Background: Mucociliary clearance (MCC) rate from the lung has been shown to be reduced in chronic obstructive pulmonary disease (COPD). This study compared the use of change in penetration index (PI) with conventional whole lung clearance in assessi
Publikováno v:
Nuclear medicine communications. 40(4)
Background Measurement errors occurring during glomerular filtration rate (GFR) studies propagate to an error in the calculated GFR. Previous work has modelled measurement errors for slope-intercept (SI-GFR), single-sample (SS-GFR) and slope-only (SO
Autor:
Caroline Majoral, Jose G. Venegas, Elliot Greenblatt, Marine Pichelin, Spyridon Montesantos, Ira Katz, Georges Caillibotte, Joy Conway, John S. Fleming, Andrew R. Martin
Publikováno v:
Journal of Aerosol Medicine and Pulmonary Drug Delivery. 27:71-80
Helium-oxygen has been used for decades as a respiratory therapy conjointly with aerosols. It has also been shown under some conditions to be a means to provide more peripheral, deeper, particle deposition for inhalation therapies. Furthermore, we ca
Autor:
Joy Conway, Caroline Majoral, Ira Katz, Michael J. Bennett, Georges Caillibotte, John S. Fleming, Spyridon Montesantos
Publikováno v:
Journal of Aerosol Medicine and Pulmonary Drug Delivery. 27:35-42
Determination of the lung outline and regional lung air volume is of value in analysis of three-dimensional (3D) distribution of aerosol deposition from radionuclide imaging. This study describes a technique for using computed tomography (CT) scans f
Autor:
John S. Fleming, Glen M. Blake, Mark C. Barnfield, Maria Burniston, Anthony W. Murray, P. S. Cosgriff
Publikováno v:
Nuclear Medicine Communications. 36:295-297
We read with interest the article by Pottel et al. [1] 'Measuring glomerular filtration rate using 51Cr-EDTA: body surface area normalization before or after Bröchner-Mortensen correction?' The authors question the basis for the recommendation in th
Autor:
Lorenzo Biassoni, Robin J. McAnulty, Livia Tossici-Bolt, Stephen L. Hart, Stephen E. Bottoms, John S. Fleming, Deborah Ridout, Maria Manunta, Geoffrey J. Laurent, Christopher O'Callaghan, Jing Jin, Amy R. McDowell
Publikováno v:
American Journal of Respiratory Cell and Molecular Biology. 49:471-480
Receptor-targeted nanocomplexes are nonviral vectors developed for gene delivery to the airway epithelium for the treatment of pulmonary disease associated with cystic fibrosis. The present study aimed to optimize the delivery of the nanocomplex by n
Autor:
Benoit Piednoir, Marine Pichelin, Carolin Majoral, Joëlle Texereau, Joy Conway, Cecile Dubau, Ira Katz, Georges Caillibotte, Spyridon Montesantos, John S. Fleming
Publikováno v:
The Anatomical Record. 296:852-866
Models of the human respiratory tract developed in the past were based on measurements made on human tracheobronchial airways of healthy subjects. With the exception of a few morphometric characteristics such as the bronchial wall thickness (WT), ver
Autor:
Marine Pichelin, Caroline Majoral, John S. Fleming, Michael J. Bennett, Ted B. Martonen, Ira Katz, Spyridon Montesantos, Georges Caillibotte, Joy Conway
Publikováno v:
Aerosol Science and Technology. 47:714-723
Preliminary comparisons of simulation results from existing extrathoracic (ET) models and a lung deposition model with individualized, two-dimensional and three-dimensional (3D) imaging measurements of aerosol deposition in the respiratory tract of h
Autor:
Stephan Ehrmann, Guenther Hochhaus, Steve Newman, R. Siekmeier, Gerhard Scheuch, Gabriela Apiou-Sbirlea, John S. Fleming, Anthony J. Hickey
Publikováno v:
Therapeutic Delivery. 4:343-367
Interest in bioequivalence (BE) of inhaled drugs derives largely from the desire to offer generic substitutes to successful drug products. The complexity of aerosol dosage forms renders them difficult to mimic and raises questions regarding definitio