Zobrazeno 1 - 10
of 62
pro vyhledávání: '"John S. Davies"'
Autor:
Cristiane J. Nunes-Santos, HyeSun Kuehn, Brigette Boast, SuJin Hwang, Douglas B. Kuhns, Jennifer Stoddard, Julie E. Niemela, Danielle L. Fink, Stefania Pittaluga, Mones Abu-Asab, John S. Davies, Valarie A. Barr, Tomoki Kawai, Ottavia M. Delmonte, Marita Bosticardo, Mary Garofalo, Magda Carneiro-Sampaio, Raz Somech, Mohammad Gharagozlou, Nima Parvaneh, Lawrence E. Samelson, Thomas A. Fleisher, Anne Puel, Luigi D. Notarangelo, Bertrand Boisson, Jean-Laurent Casanova, Beata Derfalvi, Sergio D. Rosenzweig
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-12 (2023)
Abstract We describe the first cases of germline biallelic null mutations in ARPC5, part of the Arp2/3 actin nucleator complex, in two unrelated patients presenting with recurrent and severe infections, early-onset autoimmunity, inflammation, and dys
Externí odkaz:
https://doaj.org/article/70df5eaacfeb4302a635c2f9e2561b5d
Autor:
James L Gulley, Ling Zhang, Julius Strauss, Carylinda Serna, Christian S Hinrichs, John S Davies, Scott Norberg, Farrah Karimipour, Nisha Nagarsheth, Shinheng Chiou
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 10, Iss 7 (2022)
Background Cell therapy has shown promise in the treatment of certain solid tumors, but its efficacy may be limited by inhibition of therapeutic T cells by the programmed cell death protein-1 (PD-1) receptor. Clinical trials are testing cell therapy
Externí odkaz:
https://doaj.org/article/d13f3f2b4a89459b96e76f870d7f52dd
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 8, Iss 1 (2020)
BackgroundInterleukin-12 (IL-12) is a potent, proinflammatory cytokine that holds promise for cancer immunotherapy, but its clinical use has been limited by its toxicity. To minimize systemic exposure and potential toxicity while maintaining the bene
Externí odkaz:
https://doaj.org/article/5a954c5e20fb42ada60e8f5815b0eca7
Autor:
Sooraj R. Achar, François X. P. Bourassa, Thomas J. Rademaker, Angela Lee, Taisuke Kondo, Emanuel Salazar-Cavazos, John S. Davies, Naomi Taylor, Paul François, Grégoire Altan-Bonnet
Publikováno v:
Science. 376:880-884
Systems immunology lacks a framework with which to derive theoretical understanding from high-dimensional datasets. We combined a robotic platform with machine learning to experimentally measure and theoretically model CD8 + T cell activation. High-d
Autor:
John S Davies, Farrah Karimipour, Ling Zhang, Nisha Nagarsheth, Scott Norberg, Carylinda Serna, Julius Strauss, Shinheng Chiou, James L Gulley, Christian S Hinrichs
Publikováno v:
Journal for immunotherapy of cancer. 10(7)
BackgroundCell therapy has shown promise in the treatment of certain solid tumors, but its efficacy may be limited by inhibition of therapeutic T cells by the programmed cell death protein-1 (PD-1) receptor. Clinical trials are testing cell therapy i
Publikováno v:
The Journal of Immunology. 204:246.1-246.1
Adoptive T cell therapy (ACT) has yielded promising clinical results but improvements are needed. Cell therapy efficacy may be improved by blockade of the inhibitory receptor PD1. Independent T cell models demonstrated cooperation between ACT and α-
Autor:
Loai Al-Jamri, John S. Davies
Publikováno v:
Journal of Peptide Science. 8:663-670
Two building blocks, Boc-Lys(Bn4-DTPA)-OH and Fmoc-Lys(-DTPA)-OH have been synthesized via the acylation of the e-amino group of Nα-protected lysine, using suitably protected tetra-esters of diethylene triamine pentaacetic acid (DTPA), a ligand with
Publikováno v:
Journal of the Chemical Society, Perkin Transactions 1. :239-243
A synthetic route to a novel α,α-diamino β-keto ethoxycarbonyl-containing dioxopiperazine, capable of mimicking a β-turn, is reported. The cis configuration of the dioxopiperazine has been rationalised by NMR spectroscopy, while computational ene
Publikováno v:
Journal of the Chemical Society, Perkin Transactions 1. :2907-2915
Cyclopentapeptides containing the Arg-Gly-Asp motif have been synthesised using solid-phase assembly of side-chain-protected linear precursors, followed by solution-phase cyclisation. The replacement of the Asp residue by γ-carboxyglutamic acid (Gla