Zobrazeno 1 - 10
of 167
pro vyhledávání: '"John S. Coon"'
Autor:
Azna Zuberi, Yongchao Huang, Ariel J. Dotts, Helen Wei, John S. Coon V, Shimeng Liu, Takashi Iizuka, Olivia Wu, Olivia Sotos, Priyanka Saini, Debabrata Chakravarti, Thomas G. Boyer, Yang Dai, Serdar E. Bulun, Ping Yin
Publikováno v:
JCI Insight, Vol 8, Iss 18 (2023)
Uterine leiomyomas cause heavy menstrual bleeding, anemia, and pregnancy loss in millions of women worldwide. Driver mutations in the transcriptional mediator complex subunit 12 (MED12) gene in uterine myometrial cells initiate 70% of leiomyomas that
Externí odkaz:
https://doaj.org/article/d0e7da5cad5e4be6b2a1e703a85ac26f
Autor:
Kaoru Miyazaki, Matthew T. Dyson, John S. Coon V, Yuichi Furukawa, Bahar D. Yilmaz, Tetsuo Maruyama, Serdar E. Bulun
Publikováno v:
Stem Cell Reports, Vol 11, Iss 5, Pp 1136-1155 (2018)
Summary: Defective endometrial stromal fibroblasts (EMSFs) contribute to uterine factor infertility, endometriosis, and endometrial cancer. Induced pluripotent stem cells (iPSCs) derived from skin or bone marrow biopsies provide a patient-specific so
Externí odkaz:
https://doaj.org/article/691443205b9f4945ad395bd58461841f
Publikováno v:
International Journal of Breast Cancer, Vol 2012 (2012)
Although the incidence of breast cancer in the United States is higher in Caucasian women compared with African American women, African-American patients have more aggressive disease as characterized by a higher percentage of triple-negative breast c
Externí odkaz:
https://doaj.org/article/8c6cc445062f42dbabff77910f99d18d
Autor:
Takashi Iizuka, Ping Yin, Azna Zuberi, Stacy Kujawa, John S. Coon, Richelle D. Björvang, Pauliina Damdimopoulou, Diana C. Pacyga, Rita S. Strakovsky, Jodi A. Flaws, Serdar E. Bulun
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America. 119(47)
Uterine leiomyoma is the most common tumor in women and causes severe morbidity in 15 to 30% of reproductive-age women. Epidemiological studies consistently indicate a correlation between leiomyoma development and exposure to endocrine-disrupting che
Autor:
Anne P. Hutchinson, Ping Yin, Ilona Neale, John S. Coon, Stacy A. Kujawa, Shimeng Liu, Serdar E. Bulun
Publikováno v:
Reproductive sciences (Thousand Oaks, Calif.). 29(3)
Uterine leiomyomas (fibroids) are common benign tumors in women. The tryptophan metabolism through the kynurenine pathway plays important roles in tumorigenesis in general. Leiomyomas expressing mutated mediator complex subunit 12 (mut-MED12) were re
Publikováno v:
Oncogene
Progesterone and its receptor, PR, are essential for uterine leiomyoma (LM, a.k.a., fibroid) tumorigenesis, but the underlying cellular and molecular mechanisms remain unclear. The receptor activator of NF-κB (RANKL) was recently identified as a nov
Autor:
K. Miyazaki, Bahar D. Yilmaz, Serdar E. Bulun, John S. Coon, Matthew T. Dyson, Tetsuo Maruyama, Yuichi Furukawa
Publikováno v:
Stem Cell Reports, Vol 11, Iss 5, Pp 1136-1155 (2018)
Stem Cell Reports
Stem Cell Reports
Summary Defective endometrial stromal fibroblasts (EMSFs) contribute to uterine factor infertility, endometriosis, and endometrial cancer. Induced pluripotent stem cells (iPSCs) derived from skin or bone marrow biopsies provide a patient-specific sou
Autor:
Ariel J. Dotts, Serdar E. Bulun, Shimeng Liu, Ping Yin, Yang Dai, Stacy A. Kujawa, Jingting Xu, Hong Zhao, John S. Coon
Publikováno v:
Stem Cell Reports
Summary Uterine leiomyoma (LM) is the most common tumor in women. Via its receptor (PGR) expressed in differentiated LM cells, progesterone stimulates paracrine signaling that induces proliferation of PGR-deficient LM stem cells (LSCs). Antiprogestin
Autor:
Debabrata Chakravarti, Serdar E. Bulun, Stacy A. Kujawa, Ariel J. Dotts, Shimeng Liu, Jian Jun Wei, Ping Yin, John S. Coon
Publikováno v:
Fertil Steril
Objective To investigate the functional interaction between the Wnt/β-catenin and protein kinase B (Akt) pathways in leiomyoma stem cells (LSC). Design Laboratory study. Setting Research laboratory. Patient(s) Premenopausal women (n = 36; age range:
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::09152f288be50d433cf3c2260bc2b2c7
https://europepmc.org/articles/PMC7722234/
https://europepmc.org/articles/PMC7722234/
Autor:
Jon E. Levine, Hong Zhao, Serdar E. Bulun, Xia Xu, Hongxin Dong, David C. Brooks, Cihangir Mutlu Ercan, John S. Coon
Publikováno v:
Endocrinology
The biologically active estrogen estradiol has important roles in adult brain physiology and sexual behavior. A single gene, Cyp19a1, encodes aromatase, the enzyme that catalyzes the conversion of testosterone to estradiol in the testis and brain of