Zobrazeno 1 - 10
of 20
pro vyhledávání: '"John S. Chorba"'
Autor:
Adri M. Galvan, John S. Chorba
Publikováno v:
Journal of Lipid Research, Vol 60, Iss 1, Pp 71-84 (2019)
Proprotein convertase subtilisin/kexin type 9 (PCSK9) targets the LDL receptor (LDLR) for degradation, increasing plasma LDL and, consequently, cardiovascular risk. Uptake of secreted PCSK9 is required for its effect on the LDLR, and LDL itself inhib
Externí odkaz:
https://doaj.org/article/7e7c2737d9b84f45a036b73f5acb1aeb
Autor:
John S. Chorba, Avi M. Shapiro, Le Le, John Maidens, John Prince, Steve Pham, Mia M. Kanzawa, Daniel N. Barbosa, Caroline Currie, Catherine Brooks, Brent E. White, Anna Huskin, Jason Paek, Jack Geocaris, Dinatu Elnathan, Ria Ronquillo, Roy Kim, Zenith H. Alam, Vaikom S. Mahadevan, Sophie G. Fuller, Grant W. Stalker, Sara A. Bravo, Dina Jean, John J. Lee, Medeona Gjergjindreaj, Christos G. Mihos, Steven T. Forman, Subramaniam Venkatraman, Patrick M. McCarthy, James D. Thomas
Publikováno v:
Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, Vol 10, Iss 9 (2021)
Background Clinicians vary markedly in their ability to detect murmurs during cardiac auscultation and identify the underlying pathological features. Deep learning approaches have shown promise in medicine by transforming collected data into clinical
Externí odkaz:
https://doaj.org/article/e45493abbc90480aa8c8c373ac9ed160
Publikováno v:
Arteriosclerosis, thrombosis, and vascular biology, vol 43, iss 2
Background: PCSK9 (proprotein convertase subtilisin-kexin type 9) chaperones the hepatic LDLR (low-density lipoprotein receptor) for lysosomal degradation, elevating serum LDL (low-density lipoprotein) cholesterol and promoting atherosclerotic heart
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3de2f5095520eb980b40e0b35714278d
https://pubmed.ncbi.nlm.nih.gov/36475702
https://pubmed.ncbi.nlm.nih.gov/36475702
BackgroundPCSK9 chaperones the hepatic low-density lipoprotein receptor (LDLR) for lysosomal degradation, elevating serum LDL cholesterol and increasing the risk of atherosclerotic heart disease. Though the major effect on the hepatic LDLR comes from
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0cd25068e7481795b3947fc8c4144a3f
https://doi.org/10.1101/2022.09.12.22279796
https://doi.org/10.1101/2022.09.12.22279796
Autor:
Geoffrey A. Smith, Arun Padmanabhan, Bryan H. Lau, Akhil Pampana, Li Li, Clara Y. Lee, Angelo Pelonero, Tomohiro Nishino, Nandhini Sadagopan, Vivian Q. Xia, Rajan Jain, Pradeep Natarajan, Roland S. Wu, Brian L. Black, Deepak Srivastava, Kevan M. Shokat, John S. Chorba
Publikováno v:
Sci Transl Med
The low-density lipoprotein receptor (LDLR) controls cellular delivery of cholesterol and clears LDL from the bloodstream, protecting against atherosclerotic heart disease, the leading cause of death in the United States. We therefore sought to ident
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e1885a2e1fa6ddfcc35fee9491a35275
https://pubmed.ncbi.nlm.nih.gov/36103516
https://pubmed.ncbi.nlm.nih.gov/36103516
Publikováno v:
JAMA internal medicine, vol 182, iss 5
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5fc5d73eff911279e3b9aa3b9589f76f
https://doi.org/10.1001/jamainternmed.2022.0399
https://doi.org/10.1001/jamainternmed.2022.0399
Autor:
Kevan M. Shokat, Akhil Pampana, Arun Padmanabhan, Tomohiro Nishino, Brian L. Black, Pradeep Natarajan, Geoffrey A. Smith, Deepak Srivastava, Youngna Clara Lee, John S. Chorba, Angelo Pelonero, Nandhini Sadagopan, Rajan Jain, Bryan H Lau, Li Li, Roland S. Wu
The low-density lipoprotein receptor (LDLR) controls cellular delivery of cholesterol and clears LDL from the bloodstream, protecting against atherosclerotic heart disease, the leading cause of death in the United States. We therefore sought to ident
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3d632a890c1d74fc03f437060736e075
https://doi.org/10.1101/2020.08.03.235028
https://doi.org/10.1101/2020.08.03.235028
Autor:
Pedro Beltrao, Phillip P. Sharp, Nevan J. Krogan, Sabrina J. Fletcher, Saker Klippsten, Trey Ideker, Melanie Ott, Bryan L. Roth, Xi Liu, Devin A. Cavero, Djoshkun Shengjuler, Christopher J.P. Mathy, Jason C.J. Chang, Theodore L. Roth, Hannes Braberg, Claudia Hernandez-Armenta, Lisa Miorin, Jyoti Batra, Shizhong Dai, Maliheh Safari, Brian K. Shoichet, Danish Memon, Tia A. Tummino, Marco Vignuzzi, Mark von Zastrow, Manon Eckhardt, Alan D. Frankel, Qiongyu Li, Tanja Kortemme, Nicole A. Wenzell, Zun Zar Chi Naing, Ferdinand Roesch, Nastaran Sadat Savar, Mathieu Hubert, Xi Ping Huang, Elena Moreno, Danica Galonić Fujimori, Jeffrey Z. Guo, Natalia Jura, Kirsten Obernier, Kliment A. Verba, Harmit S. Malik, Hao-Yuan Wang, Michael McGregor, Melanie J. Bennett, Julia Noack, Gwendolyn M. Jang, Paige Haas, Alice Mac Kain, Daniel J. Saltzberg, Mehdi Bouhaddou, Ziyang Zhang, Yongfeng Liu, Inigo Barrio-Hernandez, Yiming Cai, Kris M. White, Kelsey M. Haas, Maya Modak, Stephanie A. Wankowicz, Raphael Trenker, Kevan M. Shokat, Fatima S. Ugur, Shiming Peng, Sai J. Ganesan, Shaeri Mukherjee, Yuan Zhou, Minkyu Kim, John D. Gross, Jack Taunton, Alicia L. Richards, John S. Chorba, Margaret Soucheray, Danielle L. Swaney, Benjamin J. Polacco, Alan Ashworth, Wenqi Shen, Adolfo García-Sastre, Merve Cakir, Ujjwal Rathore, Kala Bharath Pilla, Michael C. O’Neal, Ying Shi, Kevin Lou, Cassandra Koh, Stephen N. Floor, Davide Ruggero, Ilsa T Kirby, Srivats Venkataramanan, Ruth Hüttenhain, Olivier Schwartz, Beril Tutuncuoglu, Christophe d'Enfert, Jose Liboy-Lugo, David A. Agard, Charles S. Craik, Veronica V. Rezelj, Tina Perica, Matthew P. Jacobson, Lorenzo Calviello, Eric Verdin, Yizhu Lin, Jiankun Lyu, Jiewei Xu, Joseph Hiatt, Andrej Sali, Oren S. Rosenberg, Markus Bohn, David E. Gordon, James S. Fraser, Sara Brin Rosenthal, Duygu Kuzuoğlu-Öztürk, Robyn M. Kaake, Jacqueline M. Fabius, Matthew J. O’Meara, Quang Dinh Tran, Advait Subramanian, Thomas Vallet, Bjoern Meyer, James E. Melnyk, Robert M. Stroud, Helene Foussard, Rakesh Ramachandran, David J. Broadhurst, Janet M. Young, Michael Emerman
Publikováno v:
Nature
Schizophrenia Research
Schizophrenia Research
A newly described coronavirus named severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), which is the causative agent of coronavirus disease 2019 (COVID-19), has infected over 2.3 million people, led to the death of more than 160,000 individ
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2c7a27bfab90141dd62b3e0487aafd54
Autor:
John S. Chorba, Daniel N. Barbosa, John Prince, Jason Paek, Sophie G. Fuller, Grant W. Stalker, Subramaniam Venkatraman, Avi M. Shapiro, Sara A. Bravo, Dina Jean, Le Le, John Maidens, Steve Pham, Brent E. White, Patrick M. McCarthy, James D. Thomas, Mia M. Kanzawa
BackgroundThere is variability among clinicians in their ability to detect murmurs during cardiac auscultation and identify the underlying pathology. Deep learning approaches have shown promise in medicine by transforming collected data into clinical
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9e89d4156eac6405b7720bb686851fd1
https://doi.org/10.1101/2020.04.01.20050518
https://doi.org/10.1101/2020.04.01.20050518
Autor:
David E. Gordon, Gwendolyn M. Jang, Qiongyu Li, Natalia Jura, Sara Brin Rosenthal, Trey Ideker, Paige Haas, Melanie J. Bennett, Ilsa T Kirby, Adolfo García-Sastre, Michael Emerman, Thomas Vallet, Tina Perica, Lorenzo Calviello, Kirsten Obernier, Kliment A. Verba, Tanja Kortemme, Michael McGregor, Alan Ashworth, Ujjwal Rathore, Ziyang Zhang, Kelsey M. Haas, Rakesh Ramachandran, Mark von Zastrow, Jacqueline M. Fabius, Theodore L. Roth, Daniel J. Saltzberg, Matthew P. Jacobson, Kevin Lou, Ferdinand Roesch, Yizhu Lin, John S. Chorba, Beril Tutuncuoglu, Claudia Hernandez-Armenta, Harmit S. Malik, Janet M. Young, Manon Eckhardt, Srivats Venkataramanan, Jose Liboy-Lugo, Phillip P. Sharp, Jeffrey Z. Guo, Maya Modak, Shaeri Mukherjee, Markus Bohn, Brian K. Shoichet, Olivier Schwartz, Jiewei Xu, James S. Fraser, Andrej Sali, Oren S. Rosenberg, Christopher J.P. Mathy, Charles S. Craik, Benjamin J. Polacco, Melanie Ott, Sai J. Ganesan, Pedro Beltrao, Alicia L. Richards, Helene Foussard, Margaret Soucheray, Joseph Hiatt, Robyn M. Kaake, Danielle L. Swaney, Wenqi Shen, Bjoern Meyer, Kala Bharath Pilla, Zun Zar Chi Naing, Marco Vignuzzi, James E. Melnyk, John D. Gross, Shiming Peng, Mehdi Bouhaddou, Nevan J. Krogan, Merve Cakir, Mathieu Hubert, Stephanie A. Wankowicz, Ying Shi, Davide Ruggero, Kevan M. Shokat, Stephen N. Floor, Jack Taunton, Xi Liu, Ruth Hüttenhain, David A. Agard, Lisa Miorin, Danish Memon, Julia Noack, Raphael Trenker, Hannes Braberg, Shizhong Dai, Tia A. Tummino, Kris M. White, Yuan Zhou, Minkyu Kim, Devin A. Cavero, Jyoti Batra, Advait Subramanian, Danica Galonić Fujimori, Inigo Barrio-Hernandez
Publikováno v:
bioRxiv : the preprint server for biology, vol 1, iss 05-20
bioRxiv
article-version (status) pre
article-version (number) 1
bioRxiv
article-version (status) pre
article-version (number) 1
Author(s): Gordon, David E; Jang, Gwendolyn M; Bouhaddou, Mehdi; Xu, Jiewei; Obernier, Kirsten; O'Meara, Matthew J; Guo, Jeffrey Z; Swaney, Danielle L; Tummino, Tia A; Huttenhain, Ruth; Kaake, Robyn M; Richards, Alicia L; Tutuncuoglu, Beril; Foussard
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8c8186932c52fbde3f27787d30adc7ec
https://escholarship.org/uc/item/9v71w6zc
https://escholarship.org/uc/item/9v71w6zc