Zobrazeno 1 - 10
of 59
pro vyhledávání: '"John S. Carey"'
Publikováno v:
Organic Process Research & Development. 25:2502-2507
Publikováno v:
Organic Process Research & Development. 25:136-147
This paper describes the process development conducted toward the multi-kilogram synthesis of a novel transported pro-drug of R-baclofen. The key steps in the synthesis were the enzyme-catalyzed ki...
Autor:
Robin Marshall, Catherine Smyth, J. Alf Davis, Alasdair Garnett, Julian Scott Northen, John S. Carey, Stephen J. Byard, Urvish Pandya, Stephen John Martin, Antonio Codina, Gary Patrick Reid, John Mykytiuk, Sophie L. Berrell, Katherine Filer, Lesa Watson
Publikováno v:
Organic Process Research & Development. 23:762-770
This paper describes the process development conducted toward the multi-kilogram synthesis of a hemiadipic acid pro-drug of buprenorphine. The major challenges were to control the levels of the dibuprenorphine monoadipate impurity and to improve the
Autor:
John S. Carey, Emily McCann
Publikováno v:
Organic Process Research & Development. 23:771-774
This paper describes the development of an alternative route toward a hemiadipic acid pro-drug of buprenorphine. Buprenorphine was acylated with adipic acid monoethyl ester. A regioselective ester hydrolysis using C. antarctica lipase B cleaved the s
Autor:
Paul Spurr, Karen E. Holt-Tiffin, Wilfried Hoffmann, Mark Dow, Rhona Sinclair, Stewart T. Hayes, Rebecca Meadows, Roger M. Howard, Robert Walton, Andrew S. Wells, M. C. Lloyd, Fiona Rawlinson, Beat Wirz, Colin M. Burns, Gemma Scotney, Sarah L. Spencer, Gregory Hughes, Christophe Pfleger, Matthew D. Truppo, Gordon Ward, Graham Checksfield, John S. Carey, Neil Barnwell, Gary F. Breen, Christian T. Regius
Publikováno v:
Practical Methods for Biocatalysis and Biotransformations 2
Autor:
Guillaume Roux, Fiona Rawlinson, Alcide Perboni, Michael Anthony Forth, Darren Caine, Adam Banks, Christopher Drake, Matthew E. Popkin, Jerome F. Hayes, John S. Carey, Asa Gladwin, Paolo Maragni, Gary F. Breen, David O. Morgan, Paul Oxley, Simone Guelfi
Publikováno v:
Organic Process Research & Development. 13:1130-1140
A synthetic route amenable to large-scale synthesis of the glycine antagonist (2R,4E)-7-chloro-4-(2-oxo-1-phenyl-pyyrrolidin-3-ylidene)-1,2,3,4-tetrahydroquinoline-2-carboxylic acid, (2R,3R,4R,5S)-6-(methylamino)hexane-1,2,3,4,5-penta-ol 12 is presen
Autor:
Carine Vaxelaire, Michael R. Webb, Alan M. Chapman, Bahareh Tavassoli, Guillaume Roux, Nigel Hussain, David J. Whatrup, Ranjit Chima, Matthew E. Popkin, John S. Carey, Georges-Emmanuel Benoit
Publikováno v:
Organic Process Research & Development. 12:88-95
The large-scale preparation of 2-methyloxazole-4-carboxaldehyde presents a significant challenge due to the physical characteristics of the molecule. A method for the preparation of 10-kg batches of 2-methyloxazole-4-carboxaldehyde is described. The
Publikováno v:
Marine Geology. 218:155-173
Glacial isostasy and the sediment supply changes associated with the waxing and waning of ice sheets have dramatic effects on the stratigraphy of adjacent continental shelves. In ancient stratigraphic records, the glacial influences on such deposits
Autor:
Laurence C. Powling, Nigel Hussain, Richard K. Bellingham, John S. Carey, David O. Morgan, Paul Oxley
Publikováno v:
Organic Process Research & Development. 8:279-282
A modified Knorr pyrrole reaction is described which may have practical benefits for the large-scale synthesis of SB-342219. The use of zinc to reduce a phenylhydrazone is replaced by the hydrogenation of the corresponding oxime to provide a common a
Autor:
Ian P. Andrews, John S. Carey, Richard J. Atkins, David O. Morgan, Gary F. Breen, Andrew S. Wells, Timothy Charles Walsgrove, Stephen A. Smith, Amin Shamji, Michael Anthony Forth, Andrew C. Share
Publikováno v:
Organic Process Research & Development. 7:655-662
The development of an efficient manufacturing route to 2,3,4,5-tetrahydro-4-methyl-3-oxo-1H-1,4-benzodiazepine-2-acetic acid methyl ester SB-235349, a key intermediate in the synthesis of lotrafiban is described. The synthesis starts with 2-nitrobenz