Zobrazeno 1 - 10
of 20
pro vyhledávání: '"John S. Burg"'
Autor:
Naotaka Tsutsumi, Somnath Mukherjee, Deepa Waghray, Claudia Y Janda, Kevin M Jude, Yi Miao, John S Burg, Nanda Gowtham Aduri, Anthony A Kossiakoff, Cornelius Gati, K Christopher Garcia
Publikováno v:
eLife, Vol 9 (2020)
Frizzleds (Fzd) are the primary receptors for Wnt morphogens, which are essential regulators of stem cell biology, yet the structural basis of Wnt signaling through Fzd remains poorly understood. Here we report the structure of an unliganded human Fz
Externí odkaz:
https://doaj.org/article/ba3f9afaf5564636a239b4ee91e21fd8
Autor:
Timothy F Miles, Katja Spiess, Kevin M Jude, Naotaka Tsutsumi, John S Burg, Jessica R Ingram, Deepa Waghray, Gertrud M Hjorto, Olav Larsen, Hidde L Ploegh, Mette M Rosenkilde, K Christopher Garcia
Publikováno v:
eLife, Vol 7 (2018)
Human cytomegalovirus has hijacked and evolved a human G-protein-coupled receptor into US28, which functions as a promiscuous chemokine 'sink’ to facilitate evasion of host immune responses. To probe the molecular basis of US28’s unique ligand cr
Externí odkaz:
https://doaj.org/article/ff0943aefac04d7b91e5b86d46807864
Autor:
Deepa Waghray, Nanda G. Aduri, John S Burg, K. Christopher Garcia, Anthony A. Kossiakoff, Cornelius Gati, Kevin Jude, Yi Miao, Naotaka Tsutsumi, Somnath Mukherjee, Claudia Y. Janda
Publikováno v:
eLife, Vol 9 (2020)
eLife
eLife
Frizzleds (Fzd) are the primary receptors for Wnt morphogens, which are essential regulators of stem cell biology, yet the structural basis of Wnt signaling through Fzd remains poorly understood. Here we report the structure of an unliganded human Fz
Autor:
Nanda G. Aduri, John S Burg, Yi Miao, Naotaka Tsutsumi, Anthony A. Kossiakoff, Deepa Waghray, Cornelius Gati, K. Christopher Garcia, Somnath Mukherjee, Claudia Y. Janda, Kevin Jude
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::fcf1ce49f4f1932c5f8bcb9144f8bb73
https://doi.org/10.7554/elife.58464.sa2
https://doi.org/10.7554/elife.58464.sa2
Autor:
Olav Larsen, Jessica R. Ingram, Hidde L. Ploegh, Katja Spiess, John S Burg, K. Christopher Garcia, Timothy F Miles, Kevin Jude, Naotaka Tsutsumi, Gertrud Malene Hjortø, Deepa Waghray, Mette M. Rosenkilde
Publikováno v:
eLife, Vol 7 (2018)
Miles, T F, Spiess, K, Jude, K M, Tsutsumi, N, Burg, J S, Ingram, J R, Waghray, D, Hjorto, G M, Larsen, O, Ploegh, H L, Rosenkilde, M M & Garcia, K C 2018, ' Viral GPCR US28 can signal in response to chemokine agonists of nearly unlimited structural degeneracy ', eLife, vol. 7, e35850 . https://doi.org/10.7554/eLife.35850
eLife
Miles, T F, Spiess, K, Jude, K M, Tsutsumi, N, Burg, J S, Ingram, J R, Waghray, D, Hjorto, G M, Larsen, O, Ploegh, H L, Rosenkilde, M M & Garcia, K C 2018, ' Viral GPCR US28 can signal in response to chemokine agonists of nearly unlimited structural degeneracy ', eLife, vol. 7, e35850 . https://doi.org/10.7554/eLife.35850
eLife
Human cytomegalovirus has hijacked and evolved a human G-protein-coupled receptor into US28, which functions as a promiscuous chemokine 'sink’ to facilitate evasion of host immune responses. To probe the molecular basis of US28’s unique ligand cr
Autor:
Gertrud Malene Hjortø, Mette M. Rosenkilde, Jessica R. Ingram, Timothy F Miles, K. Christopher Garcia, Naotaka Tsutsumi, John S Burg, Hidde L. Ploegh, Olav Larsen, Kevin Jude, Deepa Waghray, Katja Spiess
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::64daee701b199c777ef5d2255e5d4685
https://doi.org/10.7554/elife.35850.041
https://doi.org/10.7554/elife.35850.041
Autor:
K. Christopher Garcia, Tong Cheng, Hua Zhu, Katja Spiess, Olav Larsen, Gertrud Malene Hjortø, Mikkel Malmgaard-Clausen, Karen Krzywkowski, Michael A. Jarvis, John S Burg, Thomas N Kledal, Mads G. Jeppesen, Kalpana Dulal, Mette M. Rosenkilde
Publikováno v:
Spiess, K, Jeppesen, M G, Malmgaard-Clausen, M, Krzywkowski, K, Dulal, K, Cheng, T, Hjortø, G M, Larsen, O, Burg, J S, Jarvis, M A, Christopher Garcia, K, Zhu, H, Kledal, T N & Rosenkilde, M M 2015, ' Rationally designed chemokine-based toxin targeting the viral G protein-coupled receptor US28 potently inhibits cytomegalovirus infection in vivo ', Proceedings of the National Academy of Sciences of the United States of America, vol. 112, no. 27, pp. 8427-8432 . https://doi.org/10.1073/pnas.1509392112
The use of receptor-ligand interactions to direct toxins to kill diseased cells selectively has shown considerable promise for treatment of a number of cancers and, more recently, autoimmune disease. Here we move the fusion toxin protein (FTP) techno
Autor:
Deepa Waghray, Hidde L. Ploegh, Abhiram Dukkipati, Evan N. Feinberg, Alessandro Angelini, Kevin Jude, AJ Venkatakrishnan, Jessica R. Ingram, K. Christopher Garcia, John S Burg, Ron O. Dror
Publikováno v:
PMC
Chemokines are small proteins that function as immune modulators through activation of chemokine G protein–coupled receptors (GPCRs). Several viruses also encode chemokines and chemokine receptors to subvert the host immune response. How protein li
Autor:
Helen M. Blau, Ho Leung Ng, Michael Z. Lin, Michelle A. Baird, Paula J. Cranfill, Amy J. Lam, Emilio Gonzalez-Gonzalez, Christopher H. Contag, Michael W. Davidson, Kang Shen, Jun Chu, Niloufar Ataie, Pengpeng Li, Stéphane Y. Corbel, Russell D. Haynes, K. Christopher Garcia, John S Burg
Publikováno v:
Nature methods
A method for non-invasive visualization of genetically labelled cells in animal disease models with micron-level resolution would greatly facilitate development of cell-based therapies. Imaging of fluorescent proteins (FPs) using red excitation light
Publikováno v:
Journal of Biological Chemistry. 285:41051-41061
In fission yeast, the endoplasmic reticulum membrane-bound proteins Sre1 and Scp1, orthologs of mammalian sterol regulatory element binding protein (SREBP) and Scap, monitor sterol synthesis as an indirect measure of oxygen supply. When cellular oxyg