Zobrazeno 1 - 10
of 15
pro vyhledávání: '"John S. Barber"'
Autor:
Mathijs Willemsen, John S. Barber, Erika Van Nieuwenhove, Frederik Staels, Margaux Gerbaux, Julika Neumann, Teresa Prezzemolo, Emanuela Pasciuto, Vasiliki Lagou, Nancy Boeckx, Jessica Filtjens, Amber De Visscher, Patrick Matthys, Rik Schrijvers, Thomas Tousseyn, Mark O’Driscoll, Giorgia Bucciol, Susan Schlenner, Isabelle Meyts, Stephanie Humblet-Baron, Adrian Liston
BACKGROUND: Severe congenital neutropenia presents with recurrent infections early in life as a result of arrested granulopoiesis. Multiple genetic defects are known to block granulocyte differentiation; however, a genetic cause remains unknown in ap
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::00b6b05840aac2c6efbcbe0bb25a5d87
https://lirias.kuleuven.be/handle/20.500.12942/715773
https://lirias.kuleuven.be/handle/20.500.12942/715773
Autor:
Julika, Neumann, Erika, Van Nieuwenhove, Lara E, Terry, Frederik, Staels, Taylor R, Knebel, Kirsten, Welkenhuyzen, Kourosh, Ahmadzadeh, Mariah R, Baker, Margaux, Gerbaux, Mathijs, Willemsen, John S, Barber, Irina I, Serysheva, Liesbeth, De Waele, François, Vermeulen, Susan, Schlenner, Isabelle, Meyts, David I, Yule, Geert, Bultynck, Rik, Schrijvers, Stephanie, Humblet-Baron, Adrian, Liston
Publikováno v:
Cellularmolecular immunology. 20(1)
Calcium signaling is essential for lymphocyte activation, with genetic disruptions of store-operated calcium (Ca
Autor:
Julika Neumann, Erika Van Nieuwenhove, Lara E. Terry, Frederik Staels, Taylor R. Knebel, Kirsten Welkenhuyzen, Kourosh Ahmadzadeh, Mariah R. Baker, Margaux Gerbaux, Mathijs Willemsen, John S. Barber, Irina I. Serysheva, Liesbeth De Waele, François Vermeulen, Susan Schlenner, Isabelle Meyts, David I. Yule, Geert Bultynck, Rik Schrijvers, Stephanie Humblet-Baron, Adrian Liston
Publikováno v:
Cellular & Molecular Immunology. 20:114-114
Autor:
Irina I. Serysheva, Isabelle Meyts, Rik Schrijvers, Mathijs Willemsen, Adrian Liston, Liesbeth De Waele, Stephanie Humblet-Baron, David I. Yule, Geert Bultynck, François Vermeulen, John S. Barber, Kirsten Welkenhuyzen, Frederik Staels, Erika Van Nieuwenhove, Taylor R. Knebel, Lara E. Terry, Margaux Gerbaux, Julika Neumann, Mariah R. Baker
Calcium signaling is essential for lymphocyte activation, with genetic disruptions resulting in severe immunodeficiency. The inositol 1,4,5-trisphosphate receptor (IP3R), formed from homo- or hetero-tetramers of the IP3R isoforms 1-3, amplifies lymph
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::16022a674fce6207cea6eb2c5f95c0cf
https://doi.org/10.1101/2021.05.29.21257775
https://doi.org/10.1101/2021.05.29.21257775
Autor:
Mieke Metzemaekers, Susan M. Schlenner, Emanuela Pasciuto, Patrick Matthys, Stephanie Humblet-Baron, Elien Smeets, Adrian Liston, Axelle Kerstens, Joost Schymkowitz, Laura Seldeslachts, Paul Proost, Sarah Haßdenteufel, Carine Wouters, Frank Claessens, Julika Neumann, Teresa Prezzemolo, Nancy Boeckx, Vasiliki Lagou, John S. Barber, Frederic Rousseau, Bert Malengier-Devlies, Rob van der Kant, Erika Van Nieuwenhove, Christine Devalck, Isabelle Meyts, Sven Lang, Richard Zimmermann, Daniele Di Marino, Sebastian Munck, Mathijs Willemsen
Publikováno v:
Journal of allergy and clinical immunology
The Journal of Allergy and Clinical Immunology
Journal of Allergy and Clinical Immunology
The Journal of Allergy and Clinical Immunology
Journal of Allergy and Clinical Immunology
Background: The molecular cause of severe congenital neutropenia (SCN) is unknown in 30% to 50% of patients. SEC61A1 encodes the α-subunit of the Sec61 complex, which governs endoplasmic reticulum protein transport and passive calcium leakage. Recen
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9b4167ed5c5db874f50ba44ce06bf3f6
http://hdl.handle.net/2013/ULB-DIPOT:oai:dipot.ulb.ac.be:2013/307196
http://hdl.handle.net/2013/ULB-DIPOT:oai:dipot.ulb.ac.be:2013/307196
Autor:
Supunnee Jirajariyavej, Weerawan Chuenarom, Nicholas Hutchings, Jintanat Ananworanich, Yuwadee Phuang-Ngern, Victor Valcour, Tanate Jadwattanakul, Duanghathai Suttichom, Silvia Ratto-Kim, Mark de Souza, Siriwat Akapirat, Peeriya Prueksakaew, Boot Kaewboon, Sukalaya Lerdlum, Somporn Tipsuk, Thep Chalermchai, John S. Barber, Pasiri Sithinamsuwan, Robert H. Paul, David Clifford, Chayada Sajjaweerawan, Jerome H. Kim, Alexandra Schuetz, James L. K. Fletcher, Mantana Pothisri, Putthachard Karnsomlap
Publikováno v:
AIDS Research and Human Retroviruses. 34:685-689
HIV-associated neurocognitive disorder (HAND) remains a challenge despite antiretroviral therapy (ART), and has been linked to monocyte/macrophage (M/M) migration to the brain. Due to the potential impact of T cell effector mechanisms in eliminating
Autor:
Michail S. Lionakis, Jonathan J. Lyons, Diego B. Lopez, Timothy J. Break, Alexandra F. Freeman, Michael P. O'Connell, John S. Barber, Yongge Zhao, Yuan Zhang, Daniel L. Barber, Monica G. Lawrence, Steven M. Holland, Chi Ma, Joshua D. Milner
Publikováno v:
Journal of Experimental Medicine. 214:2523-2533
Patients with hypomorphic mutations in STAT3 and patients with hypermorphic mutations in STAT1 share several clinical and cellular phenotypes suggesting overlapping pathophysiologic mechanisms. We, therefore, examined cytokine signaling and CD4+ T ce
Autor:
Aurelie Lenaerts, Pandelakis A. Koni, Stephanie Humblet-Baron, John S. Barber, Adrian Liston, Carlos P. Roca
Dendritic cells (DCs) are a key cell type in the initiation of the adaptive immune response. Recently, an additional role for DCs in suppressing myeloproliferation was discovered. Myeloproliferative disorder (MPD) was observed in murine studies with
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::13cc9dceedb70a7ce16144a26e34f1fc
https://lirias.kuleuven.be/handle/123456789/628962
https://lirias.kuleuven.be/handle/123456789/628962
Autor:
Katherine R. Calvo, Bradford B. Worrall, Patrycja Hoffmann, David E. Kleiner, Wanxia L. Tsai, Andrey Zavialov, Raman Sood, Alisa Gotte, Susan J. Kelly, Shawn M. Burgess, Stephen S. Rich, Hye Sun Kuehn, Thomas A. Fleisher, Martha Quezado, Amanda K. Ombrello, Sophie Hambleton, Michael S. Hershfield, Anne Jones, Dan Yang, John S. Barber, Camilo Toro, Manfred Boehm, Chyi-Chia Richard Lee, Ivona Aksentijevich, Omer Karadag, Karyl S. Barron, James C. Mullikin, Geryl Wood, Elizabeth Chalom, David T. Chin, Edward W. Cowen, Deborah L. Stone, Susan Moir, Troy R. Torgerson, Anton V. Zavialov, Virginia Pascual, Wuhong Pei, Jae Jin Chae, Nora G. Singer, Alexander Ling, Mario Abinun, Fabio Candotti, Scott E. Kasner, Elaine F. Remmers, Seza Ozen, Daniel L. Kastner, Raphaela Goldbach-Mansky, Nancy J. Ganson, Theo Heller, Marilynn Punaro, James W. Verbsky, Nicholas J. Patronas, Hawwa Alao, Christopher Silvin, Beverly K. Barham, Timothy R. Gershon, Kevin Bishop, Heidi H. Kong, Alejandra Negro, Sergio D. Rosenzweig, James F. Meschia, Massimo Gadina, Joshua D. Milner, Qing Zhou
Publikováno v:
New England Journal of Medicine. 370:911-920
BackgroundWe observed a syndrome of intermittent fevers, early-onset lacunar strokes and other neurovascular manifestations, livedoid rash, hepatosplenomegaly, and systemic vasculopathy in three unrelated patients. We suspected a genetic cause becaus
Autor:
Nan-ping Weng, Elizabeth Garabedian, Irini Sereti, Evert van Dijk, Lauren K. Yokomizo, Fabio Candotti, Virginia Sheikh, John S. Barber, Robert A. Sokolic, Joshua D. Milner, Alexandra F. Freeman
Publikováno v:
Proceedings of the National Academy of Sciences. 110:8164-8169
The ability of T-cells to respond to foreign antigens and to appropriately regulate this response is crucial for maintaining immune homeostasis. Using combinatorial peptide libraries, we functionally measured broad T-cell reactivity and observed impa