Zobrazeno 1 - 10
of 127
pro vyhledávání: '"John S Spencer"'
Autor:
Daniel Olson, Stephanie James, Thomas Jaenisch, Stephen Berman, Molly M Lamb, Emily N Gallichotte, Brian Adams, Charles Henry, Jeannine Riess, Joni Triantis van Sickle, Kellie L Hawkins, Brian T Montague, Cody Coburn, Leisha Conners Bauer, Jennifer Kovarik, Mark T Hernandez, Amy Bronson, Lucy Graham, Stephanie Hanenberg, James Kovacs, John S Spencer, Mark Zabel, Philip D Fox, Olivia Pluss, William Windsor, Geoffrey Winstanley, Michael Barer, Gregory Ebel, May Chu
Publikováno v:
BMJ Open, Vol 12, Iss 11 (2022)
Introduction This study aims to measure how transmission of SARS-CoV-2 occurs in communities and to identify conditions that lend to increased transmission focusing on congregate situations. We will measure SARS-CoV-2 in exhaled breath of asymptomati
Externí odkaz:
https://doaj.org/article/520e7065d74d4e47a08282ebf34cda76
Autor:
Edessa Negera, Melaku Tilahun, Kidist Bobosha, Saba M Lambert, Stephen L Walker, John S Spencer, Abraham Aseffa, Hazel M Dockrell, Diana N Lockwood
Publikováno v:
PLoS Neglected Tropical Diseases, Vol 12, Iss 12, p e0007035 (2018)
BACKGROUND:Erythema nodosum leprosum (ENL) is a systemic inflammatory complication occurring mainly in patients with lepromatous leprosy (LL) and borderline lepromatous leprosy (BL). Prednisolone is widely used for treatment of ENL reactions. However
Externí odkaz:
https://doaj.org/article/4a61e7bed0d944748ece899d953dd8a3
Autor:
Moises B da Silva, Juliana M Portela, Wei Li, Mary Jackson, Mercedes Gonzalez-Juarrero, Andrea Sánchez Hidalgo, John T Belisle, Raquel C Bouth, Angélica R Gobbo, Josafá G Barreto, Antonio H H Minervino, Stewart T Cole, Charlotte Avanzi, Philippe Busso, Marco A C Frade, Annemieke Geluk, Claudio G Salgado, John S Spencer
Publikováno v:
PLoS Neglected Tropical Diseases, Vol 12, Iss 6, p e0006532 (2018)
Mycobacterium leprae (M. leprae) is a human pathogen and the causative agent for leprosy, a chronic disease characterized by lesions of the skin and peripheral nerve damage. Zoonotic transmission of M. leprae to humans by nine-banded armadillos (Dasy
Externí odkaz:
https://doaj.org/article/870e3f1f0a95472baa398d3a1439a223
Autor:
Marco Andrey C Frade, Natália A de Paula, Ciro M Gomes, Sebastian Vernal, Fred Bernardes Filho, Helena B Lugão, Marilda M M de Abreu, Patrícia Botini, Malcolm S Duthie, John S Spencer, Rosa Castália F R Soares, Norma T Foss
Publikováno v:
PLoS Neglected Tropical Diseases, Vol 11, Iss 2, p e0005375 (2017)
BACKGROUND:Leprosy diagnosis is mainly based on clinical evaluation, although this approach is difficult, especially for untrained physicians. We conducted a temporary campaign to detect previously unknown leprosy cases in midwestern Brazil and to co
Externí odkaz:
https://doaj.org/article/e36720b0d1734cb6a5e0d7c98d9102c3
Autor:
John S Spencer, Malcolm S Duthie, Annemieke Geluk, Marivic F Balagon, Hee Jin Kim, William H Wheat, Delphi Chatterjee, Mary Jackson, Wei Li, Jade N Kurihara, Armi Maghanoy, Irene Mallari, Paul Saunderson, Patrick J Brennan, Hazel M Dockrell
Publikováno v:
Memorias do Instituto Oswaldo Cruz, Vol 107, Iss suppl 1, Pp 79-89 (2012)
Although leprosy is curable with drug treatment, the identification of biomarkers of infection, disease progression and treatment efficacy would greatly help to reduce the overall prevalence of the disease. Reliable biomarkers would also reduce the i
Externí odkaz:
https://doaj.org/article/3f07fa210aca4869a48e32001f658e3f
Autor:
Taru S. Dutt, John S. Spencer, Burton R. Karger, Amy Fox, Andres Obregon-Henao, Brendan K. Podell, G. Brooke Anderson, Marcela Henao-Tamayo
Publikováno v:
Frontiers in Immunology, Vol 15 (2024)
Enzyme-linked immunosorbent assay (ELISA) is a technique to detect the presence of an antigen or antibody in a sample. ELISA is a simple and cost-effective method that has been used for evaluating vaccine efficacy by detecting the presence of antibod
Externí odkaz:
https://doaj.org/article/e541c6d127904cffbb00ec9adaec42d7
Autor:
William H Wheat, Amy L Casali, Vincent Thomas, John S Spencer, Ramanuj Lahiri, Diana L Williams, Gerald E McDonnell, Mercedes Gonzalez-Juarrero, Patrick J Brennan, Mary Jackson
Publikováno v:
PLoS Neglected Tropical Diseases, Vol 8, Iss 12, p e3405 (2014)
Leprosy is a curable neglected disease of humans caused by Mycobacterium leprae that affects the skin and peripheral nerves and manifests clinically in various forms ranging from self-resolving, tuberculoid leprosy to lepromatous leprosy having signi
Externí odkaz:
https://doaj.org/article/598d36f34f7c4d09a3fb396151fcbd9a
Autor:
Deanna A Hagge, David M Scollard, Nashone A Ray, Vilma T Marks, Angelina T Deming, John S Spencer, Linda B Adams
Publikováno v:
PLoS Neglected Tropical Diseases, Vol 8, Iss 9, p e3149 (2014)
Although immunopathology dictates clinical outcome in leprosy, the dynamics of early and chronic infection are poorly defined. In the tuberculoid region of the spectrum, Mycobacterium leprae growth is restricted yet a severe granulomatous lesion can
Externí odkaz:
https://doaj.org/article/239a2474aac1493c943ed5f99f7dca3e
Autor:
Kidist Bobosha, Elisa M Tjon Kon Fat, Susan J F van den Eeden, Yonas Bekele, Jolien J van der Ploeg-van Schip, Claudia J de Dood, Karin Dijkman, Kees L M C Franken, Louis Wilson, Abraham Aseffa, John S Spencer, Tom H M Ottenhoff, Paul L A M Corstjens, Annemieke Geluk
Publikováno v:
PLoS Neglected Tropical Diseases, Vol 8, Iss 5, p e2845 (2014)
BACKGROUND:Field-applicable tests detecting asymptomatic Mycobacterium leprae (M. leprae) infection or predicting progression to leprosy, are urgently required. Since the outcome of M. leprae infection is determined by cellular- and humoral immunity,
Externí odkaz:
https://doaj.org/article/e6e66e9bc39f4fd8a06cc4374ac8a209
Autor:
Subhadra Nandakumar, Sunil Kannanganat, Karen M Dobos, Megan Lucas, John S Spencer, Sunan Fang, Melissa A McDonald, Jan Pohl, Kristin Birkness, Venkateswarlu Chamcha, Melissa V Ramirez, Bonnie B Plikaytis, James E Posey, Rama Rao Amara, Suraj B Sable
Publikováno v:
PLoS Pathogens, Vol 9, Iss 10, p e1003705 (2013)
Glycosylation is the most abundant post-translational polypeptide chain modification in nature. Although carbohydrate modification of protein antigens from many microbial pathogens constitutes important components of B cell epitopes, the role in T ce
Externí odkaz:
https://doaj.org/article/fcf78577f37e4cc6977ecb1867a11d5d